SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5HAL7

- Q5HAL7_EHRRW

UniProt

Q5HAL7 - Q5HAL7_EHRRW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutathione synthetase
Gene
gshB, Erum6640, ERWE_CDS_06960
Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Metal bindingi275 – 2751Magnesium or manganese By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi145 – 20056ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutathione synthase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Glutathione biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciERUM254945:GJ2L-728-MONOMER.
UniPathwayiUPA00142; UER00210.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
Alternative name(s):
GSH synthetase
Glutathione synthase
Gene namesi
Name:gshBUniRule annotationImported
Ordered Locus Names:Erum6640Imported, ERWE_CDS_06960Imported
OrganismiEhrlichia ruminantium (strain Welgevonden)Imported
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000001021: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi254945.Erum6640.

Structurei

3D structure databases

ProteinModelPortaliQ5HAL7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 302184ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the prokaryotic GSH synthase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0189.
HOGENOMiHOG000265022.
KOiK01920.
OMAiEISTKQG.
OrthoDBiEOG6WMHWB.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_00162. GSH_S.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01380. glut_syn. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HAL7-1 [UniParc]FASTAAdd to Basket

« Hide

MALVVAFQMD RDVVVGKDVS VKFIQEAQIR GHTVFFFTPD KLAIKNNIPV    50
ASACLVTVEQ EKLKFENVQE LFLEDMDIIF IRQNPPFDMR YITSTYILEK 100
LTKPLVINDP KFLRDYPEKL LPLLFDDFIP DTLITEDYSM LQNFYYEHKD 150
IILKPLYSYG GNDVIRINNN VDIKVIVALM IEKYKCPIIA QQFIPNINND 200
KRILLLDGKP IGVFRRRILS AGEVRTNLRV GSVAEPAELS DRDYNICLAI 250
EDKLALKGLI FAGIDVLDGY LIEINVTSPC GVLEVNKLYN VCLEKKCWDC 300
FEKKFYARCG YV 312
Length:312
Mass (Da):35,914
Last modified:February 15, 2005 - v1
Checksum:i17652D7D097A51E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR767821 Genomic DNA. Translation: CAH58396.1.
CR925678 Genomic DNA. Translation: CAI27190.1.
RefSeqiYP_180527.1. NC_005295.2.
YP_197572.1. NC_006832.1.

Genome annotation databases

EnsemblBacteriaiCAH58396; CAH58396; Erum6640.
CAI27190; CAI27190; ERWE_CDS_06960.
GeneIDi3233352.
3260875.
KEGGieru:Erum6640.
erw:ERWE_CDS_06960.
PATRICi20581260. VBIEhrRum92411_0737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR767821 Genomic DNA. Translation: CAH58396.1 .
CR925678 Genomic DNA. Translation: CAI27190.1 .
RefSeqi YP_180527.1. NC_005295.2.
YP_197572.1. NC_006832.1.

3D structure databases

ProteinModelPortali Q5HAL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 254945.Erum6640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH58396 ; CAH58396 ; Erum6640 .
CAI27190 ; CAI27190 ; ERWE_CDS_06960 .
GeneIDi 3233352.
3260875.
KEGGi eru:Erum6640.
erw:ERWE_CDS_06960.
PATRICi 20581260. VBIEhrRum92411_0737.

Phylogenomic databases

eggNOGi COG0189.
HOGENOMi HOG000265022.
KOi K01920.
OMAi EISTKQG.
OrthoDBi EOG6WMHWB.

Enzyme and pathway databases

UniPathwayi UPA00142 ; UER00210 .
BioCyci ERUM254945:GJ2L-728-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_00162. GSH_S.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
Pfami PF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01380. glut_syn. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WelgevondenImported and Welgevonden [ARC-OVI].
  2. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden [CIRAD].

Entry informationi

Entry nameiQ5HAL7_EHRRW
AccessioniPrimary (citable) accession number: Q5HAL7
Secondary accession number(s): Q5FDC9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi