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Q5HAL7

- Q5HAL7_EHRRW

UniProt

Q5HAL7 - Q5HAL7_EHRRW

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Protein

Glutathione synthetase

Gene

gshB

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Metal bindingi275 – 2751Magnesium or manganeseUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi145 – 20056ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutathione synthase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Glutathione biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciERUM254945:GJ2L-728-MONOMER.
UniPathwayiUPA00142; UER00210.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
Alternative name(s):
GSH synthetaseUniRule annotation
Glutathione synthaseUniRule annotation
Gene namesi
Name:gshBUniRule annotationImported
Ordered Locus Names:Erum6640Imported, ERWE_CDS_06960Imported
OrganismiEhrlichia ruminantium (strain Welgevonden)Imported
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000001021: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi254945.Erum6640.

Structurei

3D structure databases

ProteinModelPortaliQ5HAL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 302184ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the prokaryotic GSH synthase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0189.
HOGENOMiHOG000265022.
KOiK01920.
OMAiEISTKQG.
OrthoDBiEOG6WMHWB.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_00162. GSH_S.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01380. glut_syn. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HAL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALVVAFQMD RDVVVGKDVS VKFIQEAQIR GHTVFFFTPD KLAIKNNIPV
60 70 80 90 100
ASACLVTVEQ EKLKFENVQE LFLEDMDIIF IRQNPPFDMR YITSTYILEK
110 120 130 140 150
LTKPLVINDP KFLRDYPEKL LPLLFDDFIP DTLITEDYSM LQNFYYEHKD
160 170 180 190 200
IILKPLYSYG GNDVIRINNN VDIKVIVALM IEKYKCPIIA QQFIPNINND
210 220 230 240 250
KRILLLDGKP IGVFRRRILS AGEVRTNLRV GSVAEPAELS DRDYNICLAI
260 270 280 290 300
EDKLALKGLI FAGIDVLDGY LIEINVTSPC GVLEVNKLYN VCLEKKCWDC
310
FEKKFYARCG YV
Length:312
Mass (Da):35,914
Last modified:February 15, 2005 - v1
Checksum:i17652D7D097A51E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA. Translation: CAH58396.1.
CR925678 Genomic DNA. Translation: CAI27190.1.
RefSeqiYP_180527.1. NC_005295.2.
YP_197572.1. NC_006832.1.

Genome annotation databases

EnsemblBacteriaiCAH58396; CAH58396; Erum6640.
CAI27190; CAI27190; ERWE_CDS_06960.
GeneIDi3233352.
3260875.
KEGGieru:Erum6640.
erw:ERWE_CDS_06960.
PATRICi20581260. VBIEhrRum92411_0737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA. Translation: CAH58396.1 .
CR925678 Genomic DNA. Translation: CAI27190.1 .
RefSeqi YP_180527.1. NC_005295.2.
YP_197572.1. NC_006832.1.

3D structure databases

ProteinModelPortali Q5HAL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 254945.Erum6640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH58396 ; CAH58396 ; Erum6640 .
CAI27190 ; CAI27190 ; ERWE_CDS_06960 .
GeneIDi 3233352.
3260875.
KEGGi eru:Erum6640.
erw:ERWE_CDS_06960.
PATRICi 20581260. VBIEhrRum92411_0737.

Phylogenomic databases

eggNOGi COG0189.
HOGENOMi HOG000265022.
KOi K01920.
OMAi EISTKQG.
OrthoDBi EOG6WMHWB.

Enzyme and pathway databases

UniPathwayi UPA00142 ; UER00210 .
BioCyci ERUM254945:GJ2L-728-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_00162. GSH_S.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
Pfami PF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01380. glut_syn. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WelgevondenImported and Welgevonden [ARC-OVI]Imported.
  2. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden [CIRAD]Imported.

Entry informationi

Entry nameiQ5HAL7_EHRRW
AccessioniPrimary (citable) accession number: Q5HAL7
Secondary accession number(s): Q5FDC9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3