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Q5HAC1

- SYE1_EHRRW

UniProt

Q5HAC1 - SYE1_EHRRW

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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei241 – 2411ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciERUM254945:GJ2L-836-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:Erum7610, ERWE_CDS_08020
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000001021: Chromosome, UP000006739: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Glutamate--tRNA ligase 1PRO_0000119560Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi254945.Erum7610.

Structurei

3D structure databases

ProteinModelPortaliQ5HAC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi9 – 1911"HIGH" regionAdd
BLAST
Motifi238 – 2425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252721.
KOiK01885.
OMAiRIALFNW.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HAC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIMMTRFAPS PTGYLHVGNV RTALICWLYT RSKQGRFLLR FDDTDLQRSK
60 70 80 90 100
DDYRNEIAND LKWLQMDWDF DVRQSSRFDR YDEIFNYLLK EELIYPCYES
110 120 130 140 150
KEELDFKRKM QLKLGLPPIY DRSALKLTQD EKNKYSERDV YFRFKIDQSQ
160 170 180 190 200
LISWDDEIRG KVSFNAANIS DPIVKRADGT YTYMLPSVID DIDFDITHIV
210 220 230 240 250
RGEDHISNTA IQIQMFNALK ASVPTFSHLS LLYCDDNKIS KRVGGFSIKD
260 270 280 290 300
MQFYELEPMA INSYFAKIGT SDPIVVHTKI QDLIYTFDIT KFNQAPTQFN
310 320 330 340 350
IDDVIKLNPK VLHKMSFSDV KLRLSELNIT SPDLWDFVSG NVQKFSDIKE
360 370 380 390 400
WIRICGQTTV PVINESDQDF IKMALSVFPN GEINQDTWKT WVANIKEKTD
410 420 430 440
RKSKDIFIPL RLALTGISTG PELAKLLPIL GRAEIIRRLG YSR
Length:443
Mass (Da):51,634
Last modified:February 15, 2005 - v1
Checksum:i2B7205B4F5D3BA05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA. Translation: CAH58494.1.
CR925678 Genomic DNA. Translation: CAI27296.1.
RefSeqiYP_180623.1. NC_005295.2.
YP_197678.1. NC_006832.1.

Genome annotation databases

EnsemblBacteriaiCAH58494; CAH58494; Erum7610.
CAI27296; CAI27296; ERWE_CDS_08020.
GeneIDi3233340.
3260858.
KEGGieru:Erum7610.
erw:ERWE_CDS_08020.
PATRICi20581498. VBIEhrRum92411_0853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA. Translation: CAH58494.1 .
CR925678 Genomic DNA. Translation: CAI27296.1 .
RefSeqi YP_180623.1. NC_005295.2.
YP_197678.1. NC_006832.1.

3D structure databases

ProteinModelPortali Q5HAC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 254945.Erum7610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH58494 ; CAH58494 ; Erum7610 .
CAI27296 ; CAI27296 ; ERWE_CDS_08020 .
GeneIDi 3233340.
3260858.
KEGGi eru:Erum7610.
erw:ERWE_CDS_08020.
PATRICi 20581498. VBIEhrRum92411_0853.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252721.
KOi K01885.
OMAi RIALFNW.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci ERUM254945:GJ2L-836-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden.
  2. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden.

Entry informationi

Entry nameiSYE1_EHRRW
AccessioniPrimary (citable) accession number: Q5HAC1
Secondary accession number(s): Q5FDN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 15, 2005
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3