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Protein

Probable ATP-dependent RNA helicase DDX60-like

Gene

DDX60L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi765 – 7728ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX60-like (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 60-like
Gene namesi
Name:DDX60L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26429. DDX60L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383445.

Polymorphism and mutation databases

BioMutaiDDX60L.
DMDMi327478505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17061706Probable ATP-dependent RNA helicase DDX60-likePRO_0000318155Add
BLAST

Proteomic databases

EPDiQ5H9U9.
MaxQBiQ5H9U9.
PaxDbiQ5H9U9.
PeptideAtlasiQ5H9U9.
PRIDEiQ5H9U9.

PTM databases

iPTMnetiQ5H9U9.
PhosphoSiteiQ5H9U9.

Expressioni

Gene expression databases

BgeeiQ5H9U9.
CleanExiHS_DDX60L.
ExpressionAtlasiQ5H9U9. baseline and differential.
GenevisibleiQ5H9U9. HS.

Organism-specific databases

HPAiHPA043211.
HPA055501.

Interactioni

Protein-protein interaction databases

BioGridi124817. 4 interactions.
IntActiQ5H9U9. 2 interactions.
STRINGi9606.ENSP00000260184.

Structurei

3D structure databases

ProteinModelPortaliQ5H9U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini752 – 919168Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1205 – 1354150Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi869 – 8724DEAH box

Sequence similaritiesi

Belongs to the helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0948. Eukaryota.
KOG0949. Eukaryota.
COG4581. LUCA.
HOGENOMiHOG000169263.
HOVERGENiHBG107797.
InParanoidiQ5H9U9.
KOiK20103.
OrthoDBiEOG75F4C8.
PhylomeDBiQ5H9U9.
TreeFamiTF314846.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5H9U9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSKDHAVFF REMTQLILNE MPKAGYSSIL NDFVESNFFV IDGDSLLVTC
60 70 80 90 100
LGVKSFKWGQ NLHFFYLVEC YLVDLLSNGG QFTIVFFKDA EYAYFDFPEL
110 120 130 140 150
LSLRTALILH LQHNTNIDVQ TEFSGCLSQD WKLFLEQHYP YFLIVSEEGL
160 170 180 190 200
SDLQTYLFNF LIIHSWGMKV NVVLSSGHES DTLRFYAYTM ESTDRNQTFS
210 220 230 240 250
KENETVIQSA YKSLIQHLEE IRVLVLATHF EHLKWNDMME EAYQTLFLLQ
260 270 280 290 300
HLWSEGSDIQ RVLCVTSCSL SLRMYHRVLV HSNCLSLQEV EDFCRLRCLC
310 320 330 340 350
VAFQLHLPLS QRACSRVITC SWIRNSDSFL KMNKWCEYFI LSNLNVFGCW
360 370 380 390 400
NLNLNHVSDL YDEQLLKNIA FYYEFESTQE PHLNLGDSIR RDYEDLWNVV
410 420 430 440 450
SHLVKEFNVG KSFPLRTTRR HFLRQEKSVI QEISLEKMPS VGFIPMTSAV
460 470 480 490 500
IDEFVGDMMK DLPILKSDDP VVPSLFKQKT SDELLHWHAQ RLLSDDYDRI
510 520 530 540 550
KCHVDEQSRD PHVLDFLKKI QDYQQFYGKS LESISTKVIV TQTTRPKEDS
560 570 580 590 600
SGASGEILQN TKPHQITKKS KKKSFLKEDQ NKAQQNDDLL FSIEEEMKNN
610 620 630 640 650
LHSGIRKLED YLTSCASNSV KFGVEMLGLI ACFKAWKKHC RGEGKISKDL
660 670 680 690 700
SIAVQMMKRI HSLLERYPEI LEAEHHQYIA KCLKYLGFND LANSLDPTLI
710 720 730 740 750
GDDKNKKKYS IDIGPARFQL QYMGHYLIRD ERKDRDPRVQ DFIPNAWQQE
760 770 780 790 800
LLDVVDKNES AVIVAPTSSG KTYASYYCME KVLRESDVGV VVYVAPAKSL
810 820 830 840 850
VGQVAATVEN RFTKTLPAGR TLCGAFTRDY CHNVLNCQVL ITVPECFEIL
860 870 880 890 900
LLAPHRQKWV ERIRYVIFDE VHYLGREVGA KFWELLLVII RCPFLVLSAT
910 920 930 940 950
INNPNLLTKW LQSVKQYWKQ ADKIMEEKCI SEKQADKCLN FLQDHSYKNQ
960 970 980 990 1000
SYEVRLVLYG ERYNDLEKHI CSVKHDDVYF DHFHPCAALT TDIIEKYGFP
1010 1020 1030 1040 1050
PDLTLTPQES IQLYDTMAQV WETWPRAQEL CPEEFILFKN KIVIKKLDAR
1060 1070 1080 1090 1100
KYEENLKAEL TNWIKNGQVK KVKRVLKNLS PDSLSSSKDM VKMFPLLVEK
1110 1120 1130 1140 1150
LRQMDKLPAI FFLFKNDDVG KRAGSVCTFL EKTETKSHPH TECHSYVFAI
1160 1170 1180 1190 1200
DEVLEKVRKT QKRITKKNPK KAEKLERKKV YRAEYINFLE NLKILEISED
1210 1220 1230 1240 1250
CTYADVKALH TEITRNKDST LERVLPRVRF TRHGKELKAL AQRGIGYHHS
1260 1270 1280 1290 1300
SMYFKEKEFV EILFVKGLIR VVTATETLAL GIHMPCKSVV FAQDSVYLDA
1310 1320 1330 1340 1350
LNYRQMSGRA GRRGQDLLGN VYFFDIPLPK IKRLLASSVP ELRGQFPLSI
1360 1370 1380 1390 1400
TLVLRLMLLA SKGDDPEDAK AKVLSVLKHS LLSFKRRRAM ETLKLYFLFS
1410 1420 1430 1440 1450
LQLLIKEDYL NKKGNPKKFA GLASYLHGHE PSNLVFVNFL KRGLFHNLCK
1460 1470 1480 1490 1500
PAWKGSQQFS QDVMEKLVLV LANLFGRKYI PAKFQNANLS FSQSKVILAE
1510 1520 1530 1540 1550
LPEDFKAALY EYNLAVMKDF ASFLLIASKS VNMKKEHQLP LSRIKFTGKE
1560 1570 1580 1590 1600
CEDSQLVSHL MSCKKGRVAI SPFVCLSGNT DNDLLRPETI NQVILRTVGV
1610 1620 1630 1640 1650
SGTQAPLLWP WKLDNRGRRM PLNAYVLNFY KHNCLTRLDQ KNGMRMGQLL
1660 1670 1680 1690 1700
KCLKDFAFNI QAISDSLSEL CENKRDNVVL AFKQLSQTFY EKLQEMQIQM

SQNHLE
Length:1,706
Mass (Da):197,674
Last modified:April 5, 2011 - v2
Checksum:iF753F97440E9B69C
GO
Isoform 2 (identifier: Q5H9U9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1164-1164: I → IS
     1306-1307: MS → IM
     1308-1706: Missing.

Show »
Length:1,308
Mass (Da):152,253
Checksum:i0291869DAC6B54F5
GO

Sequence cautioni

The sequence BAB70966.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341F → L in CAI45925 (PubMed:17974005).Curated
Sequence conflicti822 – 8221L → P in BAB70966 (PubMed:14702039).Curated
Sequence conflicti831 – 8311C → R in CAI45925 (PubMed:17974005).Curated
Sequence conflicti831 – 8311C → R in BAB70966 (PubMed:14702039).Curated
Sequence conflicti959 – 9591Y → C in AL832950 (PubMed:17974005).Curated
Sequence conflicti959 – 9591Y → C in CAI45925 (PubMed:17974005).Curated
Sequence conflicti959 – 9591Y → C in BAB70966 (PubMed:14702039).Curated
Sequence conflicti1222 – 12221E → D in AL832950 (PubMed:17974005).Curated
Sequence conflicti1488 – 14881N → D in AL832950 (PubMed:17974005).Curated
Sequence conflicti1646 – 16461M → V in AL832950 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti336 – 3361C → Y.
Corresponds to variant rs12507582 [ dbSNP | Ensembl ].
VAR_055897
Natural varianti355 – 3551N → K.
Corresponds to variant rs10029536 [ dbSNP | Ensembl ].
VAR_055898
Natural varianti409 – 4091V → L.
Corresponds to variant rs13151700 [ dbSNP | Ensembl ].
VAR_055899
Natural varianti583 – 5831A → T.
Corresponds to variant rs2319850 [ dbSNP | Ensembl ].
VAR_055900
Natural varianti1080 – 10801S → C.
Corresponds to variant rs17540213 [ dbSNP | Ensembl ].
VAR_055901

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1164 – 11641I → IS in isoform 2. 2 PublicationsVSP_040820
Alternative sequencei1306 – 13072MS → IM in isoform 2. 2 PublicationsVSP_040821
Alternative sequencei1308 – 1706399Missing in isoform 2. 2 PublicationsVSP_040822Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832950 mRNA. No translation available.
CR933601 mRNA. Translation: CAI45925.1.
AC079926 Genomic DNA. No translation available.
AC093888 Genomic DNA. No translation available.
AK055595 mRNA. Translation: BAB70966.1. Different initiation.
CCDSiCCDS47161.1. [Q5H9U9-1]
RefSeqiNP_001012985.2. NM_001012967.2.
NP_001278439.1. NM_001291510.1.
UniGeneiHs.535011.

Genome annotation databases

EnsembliENST00000260184; ENSP00000260184; ENSG00000181381.
ENST00000505890; ENSP00000422202; ENSG00000181381.
ENST00000511577; ENSP00000422423; ENSG00000181381.
GeneIDi91351.
KEGGihsa:91351.
UCSCiuc003irq.5. human. [Q5H9U9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832950 mRNA. No translation available.
CR933601 mRNA. Translation: CAI45925.1.
AC079926 Genomic DNA. No translation available.
AC093888 Genomic DNA. No translation available.
AK055595 mRNA. Translation: BAB70966.1. Different initiation.
CCDSiCCDS47161.1. [Q5H9U9-1]
RefSeqiNP_001012985.2. NM_001012967.2.
NP_001278439.1. NM_001291510.1.
UniGeneiHs.535011.

3D structure databases

ProteinModelPortaliQ5H9U9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124817. 4 interactions.
IntActiQ5H9U9. 2 interactions.
STRINGi9606.ENSP00000260184.

PTM databases

iPTMnetiQ5H9U9.
PhosphoSiteiQ5H9U9.

Polymorphism and mutation databases

BioMutaiDDX60L.
DMDMi327478505.

Proteomic databases

EPDiQ5H9U9.
MaxQBiQ5H9U9.
PaxDbiQ5H9U9.
PeptideAtlasiQ5H9U9.
PRIDEiQ5H9U9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260184; ENSP00000260184; ENSG00000181381.
ENST00000505890; ENSP00000422202; ENSG00000181381.
ENST00000511577; ENSP00000422423; ENSG00000181381.
GeneIDi91351.
KEGGihsa:91351.
UCSCiuc003irq.5. human. [Q5H9U9-1]

Organism-specific databases

CTDi91351.
GeneCardsiDDX60L.
HGNCiHGNC:26429. DDX60L.
HPAiHPA043211.
HPA055501.
neXtProtiNX_Q5H9U9.
PharmGKBiPA162383445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0948. Eukaryota.
KOG0949. Eukaryota.
COG4581. LUCA.
HOGENOMiHOG000169263.
HOVERGENiHBG107797.
InParanoidiQ5H9U9.
KOiK20103.
OrthoDBiEOG75F4C8.
PhylomeDBiQ5H9U9.
TreeFamiTF314846.

Miscellaneous databases

ChiTaRSiDDX60L. human.
GenomeRNAii91351.
PROiQ5H9U9.

Gene expression databases

BgeeiQ5H9U9.
CleanExiHS_DDX60L.
ExpressionAtlasiQ5H9U9. baseline and differential.
GenevisibleiQ5H9U9. HS.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 887-1706 (ISOFORM 1).
    Tissue: Testis carcinoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 419-1165 (ISOFORM 2).

Entry informationi

Entry nameiDDX6L_HUMAN
AccessioniPrimary (citable) accession number: Q5H9U9
Secondary accession number(s): Q96ND6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.