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Protein

Serine/threonine-protein phosphatase 6 regulatory subunit 3

Gene

PPP6R3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance.2 Publications

GO - Molecular functioni

  • protein phosphatase binding Source: MGI

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • regulation of phosphoprotein phosphatase activity Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Alternative name(s):
SAPS domain family member 3
Sporulation-induced transcript 4-associated protein SAPL
Gene namesi
Name:PPP6R3
Synonyms:C11orf23, KIAA1558, PP6R3, SAPL, SAPS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1173. PPP6R3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55291.
OpenTargetsiENSG00000110075.
PharmGKBiPA25487.

Polymorphism and mutation databases

BioMutaiPPP6R3.
DMDMi88941982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461001 – 873Serine/threonine-protein phosphatase 6 regulatory subunit 3Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei315PhosphoserineBy similarity1
Modified residuei579PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei631PhosphothreonineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei722PhosphoserineCombined sources1
Modified residuei853PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5H9R7.
MaxQBiQ5H9R7.
PaxDbiQ5H9R7.
PeptideAtlasiQ5H9R7.
PRIDEiQ5H9R7.

PTM databases

iPTMnetiQ5H9R7.
PhosphoSitePlusiQ5H9R7.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000110075.
ExpressionAtlasiQ5H9R7. baseline and differential.
GenevisibleiQ5H9R7. HS.

Organism-specific databases

HPAiCAB017183.
HPA038467.
HPA038468.

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and ANKRD28.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKRD28O150845EBI-355498,EBI-359567
PPP6CO007435EBI-355498,EBI-359751
TERF2IPQ9NYB02EBI-355498,EBI-750109

GO - Molecular functioni

  • protein phosphatase binding Source: MGI

Protein-protein interaction databases

BioGridi120579. 66 interactors.
IntActiQ5H9R7. 22 interactors.
MINTiMINT-5004961.
STRINGi9606.ENSP00000377390.

Structurei

3D structure databases

ProteinModelPortaliQ5H9R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

eggNOGiKOG2073. Eukaryota.
ENOG410XRM1. LUCA.
GeneTreeiENSGT00390000009899.
HOVERGENiHBG069733.
InParanoidiQ5H9R7.
KOiK15501.
OMAiILDMFFK.
OrthoDBiEOG091G0893.
PhylomeDBiQ5H9R7.
TreeFamiTF313227.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007587. SAPS.
[Graphical view]
PANTHERiPTHR12634. PTHR12634. 1 hit.
PfamiPF04499. SAPS. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5H9R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK
60 70 80 90 100
AECLEDLVSF IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE
110 120 130 140 150
SLLMKLYSFL LNDSPLNPLL ASFFSKVLSI LISRKPEQIV DFLKKKHDFV
160 170 180 190 200
DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ DVLNWLNEEK IIQRLVEIVH
210 220 230 240 250
PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA TLEKQEIIEQ
260 270 280 290 300
LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS
310 320 330 340 350
VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL
360 370 380 390 400
ISSLLQTNTS SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL
410 420 430 440 450
ASPFENTENA TITDQDSTGD NLLLKHLFQK CQLIERILEA WEMNEKKQAE
460 470 480 490 500
GGRRHGYMGH LTRIANCIVH STDKGPNSAL VQQLIKDLPD EVRERWETFC
510 520 530 540 550
TSSLGETNKR NTVDLVTTCH IHSSSDDEID FKETGFSQDS SLQQAFSDYQ
560 570 580 590 600
MQQMTSNFID QFGFNDEKFA DQDDIGNVSF DRVSDINFTL NTNESGNIAL
610 620 630 640 650
FEACCKERIQ QFDDGGSDEE DIWEEKHIAF TPESQRRSSS GSTDSEESTD
660 670 680 690 700
SEEEDGAKQD LFEPSSANTE DKMEVDLSEP PNWSANFDVP METTHGAPLD
710 720 730 740 750
SVGSDVWSTE EPMPTKETGW ASFSEFTSSL STKDSLRSNS PVEMETSTEP
760 770 780 790 800
MDPLTPSAAA LAVQPEAAGS VAMEASSDGE EDAESTDKVT ETVMNGGMKE
810 820 830 840 850
TLSLTVDAKT ETAVFKSEEG KLSTSQDAAC KDAEECPETA EAKCAAPRPP
860 870
SSSPEQRTGQ PSAPGDTSVN GPV
Length:873
Mass (Da):97,669
Last modified:February 7, 2006 - v2
Checksum:i5B4C69991E7DE16F
GO
Isoform 2 (identifier: Q5H9R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-549: Missing.

Show »
Length:867
Mass (Da):96,957
Checksum:i9E76BCA0E23EE3DE
GO
Isoform 3 (identifier: Q5H9R7-3) [UniParc]FASTAAdd to basket
Also known as: B, C11orf23b, SAPLb

The sequence of this isoform differs from the canonical sequence as follows:
     326-376: Missing.
     516-544: Missing.
     857-873: RTGQPSAPGDTSVNGPV → SGVEIPALPGQWSQQ

Show »
Length:791
Mass (Da):88,909
Checksum:i1C936F03A484D53D
GO
Isoform 4 (identifier: Q5H9R7-4) [UniParc]FASTAAdd to basket
Also known as: A, C11orf23a, SAPLa

The sequence of this isoform differs from the canonical sequence as follows:
     326-376: Missing.
     516-544: Missing.

Show »
Length:793
Mass (Da):88,952
Checksum:iAC5BEE22285932F4
GO
Isoform 5 (identifier: Q5H9R7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     817-817: S → RVLKSYR

Show »
Length:879
Mass (Da):98,485
Checksum:iE0AE6571756853C1
GO
Isoform 6 (identifier: Q5H9R7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-544: Missing.

Show »
Length:844
Mass (Da):94,445
Checksum:iADB89AA9C567C580
GO

Sequence cautioni

The sequence AAZ99639 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91978 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB13384 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB71396 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti292P → S in CAH18675 (PubMed:17974005).Curated1
Sequence conflicti443M → V in BAB71396 (PubMed:14702039).Curated1
Sequence conflicti477N → S in CAI45957 (PubMed:17974005).Curated1
Sequence conflicti677L → P in CAI45957 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057720842A → V.Corresponds to variant rs34009811dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017140326 – 376Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_017141516 – 544Missing in isoform 3, isoform 4 and isoform 6. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_017142544 – 549Missing in isoform 2. 1 Publication6
Alternative sequenceiVSP_017143817S → RVLKSYR in isoform 5. 1 Publication1
Alternative sequenceiVSP_017144857 – 873RTGQP…VNGPV → SGVEIPALPGQWSQQ in isoform 3. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264779 mRNA. Translation: AAG36934.1.
AF264780 mRNA. Translation: AAG36935.1.
DQ111954 mRNA. Translation: AAZ99639.2. Different initiation.
AB046778 mRNA. Translation: BAB13384.2. Different initiation.
AL834471 mRNA. Translation: CAD39130.1.
CR749815 mRNA. Translation: CAH18675.1.
CR933658 mRNA. Translation: CAI45957.1.
BC007738 mRNA. Translation: AAH07738.2.
BC105933 mRNA. Translation: AAI05934.1.
BC105934 mRNA. Translation: AAI05935.1.
BC107599 mRNA. Translation: AAI07600.1.
AK001920 mRNA. Translation: BAA91978.1. Different initiation.
AK057250 mRNA. Translation: BAB71396.1. Different initiation.
CCDSiCCDS53671.1. [Q5H9R7-5]
CCDS53672.1. [Q5H9R7-1]
CCDS53673.1. [Q5H9R7-2]
CCDS53674.1. [Q5H9R7-6]
CCDS53675.1. [Q5H9R7-3]
CCDS8182.1. [Q5H9R7-4]
RefSeqiNP_001157632.1. NM_001164160.1. [Q5H9R7-5]
NP_001157633.1. NM_001164161.1. [Q5H9R7-1]
NP_001157634.1. NM_001164162.1. [Q5H9R7-2]
NP_001157635.1. NM_001164163.1. [Q5H9R7-6]
NP_001157636.1. NM_001164164.1. [Q5H9R7-3]
NP_060782.2. NM_018312.4. [Q5H9R7-4]
XP_006718676.1. XM_006718613.2. [Q5H9R7-1]
XP_006718677.1. XM_006718614.2. [Q5H9R7-2]
XP_006718681.1. XM_006718618.3. [Q5H9R7-6]
XP_006718687.1. XM_006718624.2. [Q5H9R7-4]
XP_011543442.1. XM_011545140.2. [Q5H9R7-5]
XP_016873451.1. XM_017017962.1. [Q5H9R7-5]
XP_016873452.1. XM_017017963.1. [Q5H9R7-1]
XP_016873455.1. XM_017017966.1. [Q5H9R7-2]
UniGeneiHs.503022.

Genome annotation databases

EnsembliENST00000265636; ENSP00000265636; ENSG00000110075. [Q5H9R7-4]
ENST00000393800; ENSP00000377389; ENSG00000110075. [Q5H9R7-1]
ENST00000393801; ENSP00000377390; ENSG00000110075. [Q5H9R7-5]
ENST00000524845; ENSP00000431415; ENSG00000110075. [Q5H9R7-6]
ENST00000524904; ENSP00000433058; ENSG00000110075. [Q5H9R7-2]
ENST00000529710; ENSP00000437329; ENSG00000110075. [Q5H9R7-3]
GeneIDi55291.
KEGGihsa:55291.
UCSCiuc001onu.4. human. [Q5H9R7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264779 mRNA. Translation: AAG36934.1.
AF264780 mRNA. Translation: AAG36935.1.
DQ111954 mRNA. Translation: AAZ99639.2. Different initiation.
AB046778 mRNA. Translation: BAB13384.2. Different initiation.
AL834471 mRNA. Translation: CAD39130.1.
CR749815 mRNA. Translation: CAH18675.1.
CR933658 mRNA. Translation: CAI45957.1.
BC007738 mRNA. Translation: AAH07738.2.
BC105933 mRNA. Translation: AAI05934.1.
BC105934 mRNA. Translation: AAI05935.1.
BC107599 mRNA. Translation: AAI07600.1.
AK001920 mRNA. Translation: BAA91978.1. Different initiation.
AK057250 mRNA. Translation: BAB71396.1. Different initiation.
CCDSiCCDS53671.1. [Q5H9R7-5]
CCDS53672.1. [Q5H9R7-1]
CCDS53673.1. [Q5H9R7-2]
CCDS53674.1. [Q5H9R7-6]
CCDS53675.1. [Q5H9R7-3]
CCDS8182.1. [Q5H9R7-4]
RefSeqiNP_001157632.1. NM_001164160.1. [Q5H9R7-5]
NP_001157633.1. NM_001164161.1. [Q5H9R7-1]
NP_001157634.1. NM_001164162.1. [Q5H9R7-2]
NP_001157635.1. NM_001164163.1. [Q5H9R7-6]
NP_001157636.1. NM_001164164.1. [Q5H9R7-3]
NP_060782.2. NM_018312.4. [Q5H9R7-4]
XP_006718676.1. XM_006718613.2. [Q5H9R7-1]
XP_006718677.1. XM_006718614.2. [Q5H9R7-2]
XP_006718681.1. XM_006718618.3. [Q5H9R7-6]
XP_006718687.1. XM_006718624.2. [Q5H9R7-4]
XP_011543442.1. XM_011545140.2. [Q5H9R7-5]
XP_016873451.1. XM_017017962.1. [Q5H9R7-5]
XP_016873452.1. XM_017017963.1. [Q5H9R7-1]
XP_016873455.1. XM_017017966.1. [Q5H9R7-2]
UniGeneiHs.503022.

3D structure databases

ProteinModelPortaliQ5H9R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120579. 66 interactors.
IntActiQ5H9R7. 22 interactors.
MINTiMINT-5004961.
STRINGi9606.ENSP00000377390.

PTM databases

iPTMnetiQ5H9R7.
PhosphoSitePlusiQ5H9R7.

Polymorphism and mutation databases

BioMutaiPPP6R3.
DMDMi88941982.

Proteomic databases

EPDiQ5H9R7.
MaxQBiQ5H9R7.
PaxDbiQ5H9R7.
PeptideAtlasiQ5H9R7.
PRIDEiQ5H9R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265636; ENSP00000265636; ENSG00000110075. [Q5H9R7-4]
ENST00000393800; ENSP00000377389; ENSG00000110075. [Q5H9R7-1]
ENST00000393801; ENSP00000377390; ENSG00000110075. [Q5H9R7-5]
ENST00000524845; ENSP00000431415; ENSG00000110075. [Q5H9R7-6]
ENST00000524904; ENSP00000433058; ENSG00000110075. [Q5H9R7-2]
ENST00000529710; ENSP00000437329; ENSG00000110075. [Q5H9R7-3]
GeneIDi55291.
KEGGihsa:55291.
UCSCiuc001onu.4. human. [Q5H9R7-1]

Organism-specific databases

CTDi55291.
DisGeNETi55291.
GeneCardsiPPP6R3.
HGNCiHGNC:1173. PPP6R3.
HPAiCAB017183.
HPA038467.
HPA038468.
MIMi610879. gene.
neXtProtiNX_Q5H9R7.
OpenTargetsiENSG00000110075.
PharmGKBiPA25487.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2073. Eukaryota.
ENOG410XRM1. LUCA.
GeneTreeiENSGT00390000009899.
HOVERGENiHBG069733.
InParanoidiQ5H9R7.
KOiK15501.
OMAiILDMFFK.
OrthoDBiEOG091G0893.
PhylomeDBiQ5H9R7.
TreeFamiTF313227.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

ChiTaRSiPPP6R3. human.
GenomeRNAii55291.
PROiQ5H9R7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110075.
ExpressionAtlasiQ5H9R7. baseline and differential.
GenevisibleiQ5H9R7. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007587. SAPS.
[Graphical view]
PANTHERiPTHR12634. PTHR12634. 1 hit.
PfamiPF04499. SAPS. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPP6R3_HUMAN
AccessioniPrimary (citable) accession number: Q5H9R7
Secondary accession number(s): Q3B7I1
, Q3I4Y0, Q3KR35, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.