Q5H9R7 (PP6R3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 3

Alternative name(s):
SAPS domain family member 3
Sporulation-induced transcript 4-associated protein SAPL

Gene names

Name:	PPP6R3
Synonyms:	C11orf23, KIAA1558, PP6R3, SAPL, SAPS3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	873 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. Ref.1 Ref.3
Subunit structure	Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and ANKRD28. Ref.10
Subcellular location	Cytoplasm. Nucleus Ref.3 Ref.10.
Tissue specificity	Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes. Ref.1 Ref.3
Sequence similarities	Belongs to the SAPS family.
Sequence caution	The sequence AAZ99639.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA91978.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB13384.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB71396.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of phosphoprotein phosphatase activity Inferred from direct assay PubMed 16716191. Source: MGI
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ANKRD28	O15084	3	EBI-355498,EBI-359567
PPP6C	O00743	2	EBI-355498,EBI-359751

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5H9R7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5H9R7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     544-549: Missing.

Isoform 3 (identifier: Q5H9R7-3)

Also known as: B; C11orf23b; SAPLb;

The sequence of this isoform differs from the canonical sequence as follows:
     326-376: Missing.
     516-544: Missing.
     857-873: RTGQPSAPGDTSVNGPV → SGVEIPALPGQWSQQ

Isoform 4 (identifier: Q5H9R7-4)

Also known as: A; C11orf23a; SAPLa;

The sequence of this isoform differs from the canonical sequence as follows:
     326-376: Missing.
     516-544: Missing.

Isoform 5 (identifier: Q5H9R7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     817-817: S → RVLKSYR

Isoform 6 (identifier: Q5H9R7-6)

The sequence of this isoform differs from the canonical sequence as follows:
     516-544: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 873	873	Serine/threonine-protein phosphatase 6 regulatory subunit 3		PRO_0000046100
Amino acid modifications
	Modified residue	579	1	Phosphoserine Ref.9 Ref.14 Ref.15 Ref.17
	Modified residue	617	1	Phosphoserine Ref.8 Ref.11 Ref.13 Ref.14 Ref.15 Ref.17
	Modified residue	722	1	Phosphoserine Ref.12
	Modified residue	853	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	326 – 376	51	Missing in isoform 3 and isoform 4.		VSP_017140
	Alternative sequence	516 – 544	29	Missing in isoform 3, isoform 4 and isoform 6.		VSP_017141
	Alternative sequence	544 – 549	6	Missing in isoform 2.		VSP_017142
	Alternative sequence	817	1	S → RVLKSYR in isoform 5.		VSP_017143
	Alternative sequence	857 – 873	17	RTGQP…VNGPV → SGVEIPALPGQWSQQ in isoform 3.		VSP_017144
	Natural variant	842	1	A → V. Corresponds to variant rs34009811 [ dbSNP | Ensembl ].		VAR_057720
Experimental info
	Sequence conflict	292	1	P → S in CAH18675. Ref.5
	Sequence conflict	443	1	M → V in BAB71396. Ref.7
	Sequence conflict	477	1	N → S in CAI45957. Ref.5
	Sequence conflict	677	1	L → P in CAI45957. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 7, 2006. Version 2. Checksum: 5B4C69991E7DE16F	FASTA	873	97,669
	10 20 30 40 50 60 MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK AECLEDLVSF 70 80 90 100 110 120 IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE SLLMKLYSFL LNDSPLNPLL 130 140 150 160 170 180 ASFFSKVLSI LISRKPEQIV DFLKKKHDFV DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ 190 200 210 220 230 240 DVLNWLNEEK IIQRLVEIVH PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA 250 260 270 280 290 300 TLEKQEIIEQ LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS 310 320 330 340 350 360 VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL ISSLLQTNTS 370 380 390 400 410 420 SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL ASPFENTENA TITDQDSTGD 430 440 450 460 470 480 NLLLKHLFQK CQLIERILEA WEMNEKKQAE GGRRHGYMGH LTRIANCIVH STDKGPNSAL 490 500 510 520 530 540 VQQLIKDLPD EVRERWETFC TSSLGETNKR NTVDLVTTCH IHSSSDDEID FKETGFSQDS 550 560 570 580 590 600 SLQQAFSDYQ MQQMTSNFID QFGFNDEKFA DQDDIGNVSF DRVSDINFTL NTNESGNIAL 610 620 630 640 650 660 FEACCKERIQ QFDDGGSDEE DIWEEKHIAF TPESQRRSSS GSTDSEESTD SEEEDGAKQD 670 680 690 700 710 720 LFEPSSANTE DKMEVDLSEP PNWSANFDVP METTHGAPLD SVGSDVWSTE EPMPTKETGW 730 740 750 760 770 780 ASFSEFTSSL STKDSLRSNS PVEMETSTEP MDPLTPSAAA LAVQPEAAGS VAMEASSDGE 790 800 810 820 830 840 EDAESTDKVT ETVMNGGMKE TLSLTVDAKT ETAVFKSEEG KLSTSQDAAC KDAEECPETA 850 860 870 EAKCAAPRPP SSSPEQRTGQ PSAPGDTSVN GPV
	Isoform 2 [UniParc]. Checksum: 9E76BCA0E23EE3DE	FASTA	867	96,957
	10 20 30 40 50 60 MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK AECLEDLVSF 70 80 90 100 110 120 IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE SLLMKLYSFL LNDSPLNPLL 130 140 150 160 170 180 ASFFSKVLSI LISRKPEQIV DFLKKKHDFV DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ 190 200 210 220 230 240 DVLNWLNEEK IIQRLVEIVH PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA 250 260 270 280 290 300 TLEKQEIIEQ LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS 310 320 330 340 350 360 VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL ISSLLQTNTS 370 380 390 400 410 420 SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL ASPFENTENA TITDQDSTGD 430 440 450 460 470 480 NLLLKHLFQK CQLIERILEA WEMNEKKQAE GGRRHGYMGH LTRIANCIVH STDKGPNSAL 490 500 510 520 530 540 VQQLIKDLPD EVRERWETFC TSSLGETNKR NTVDLVTTCH IHSSSDDEID FKETGFSQDS 550 560 570 580 590 600 SLQQMQQMTS NFIDQFGFND EKFADQDDIG NVSFDRVSDI NFTLNTNESG NIALFEACCK 610 620 630 640 650 660 ERIQQFDDGG SDEEDIWEEK HIAFTPESQR RSSSGSTDSE ESTDSEEEDG AKQDLFEPSS 670 680 690 700 710 720 ANTEDKMEVD LSEPPNWSAN FDVPMETTHG APLDSVGSDV WSTEEPMPTK ETGWASFSEF 730 740 750 760 770 780 TSSLSTKDSL RSNSPVEMET STEPMDPLTP SAAALAVQPE AAGSVAMEAS SDGEEDAEST 790 800 810 820 830 840 DKVTETVMNG GMKETLSLTV DAKTETAVFK SEEGKLSTSQ DAACKDAEEC PETAEAKCAA 850 860 PRPPSSSPEQ RTGQPSAPGD TSVNGPV
	Isoform 3 (B) (C11orf23b) (SAPLb) [UniParc]. Checksum: 1C936F03A484D53D	FASTA	791	88,909
	10 20 30 40 50 60 MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK AECLEDLVSF 70 80 90 100 110 120 IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE SLLMKLYSFL LNDSPLNPLL 130 140 150 160 170 180 ASFFSKVLSI LISRKPEQIV DFLKKKHDFV DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ 190 200 210 220 230 240 DVLNWLNEEK IIQRLVEIVH PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA 250 260 270 280 290 300 TLEKQEIIEQ LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS 310 320 330 340 350 360 VNKSVLEAIR GRLGSFHELL LEPPKNMFFK YTWNNFLHTQ VEICIALILA SPFENTENAT 370 380 390 400 410 420 ITDQDSTGDN LLLKHLFQKC QLIERILEAW EMNEKKQAEG GRRHGYMGHL TRIANCIVHS 430 440 450 460 470 480 TDKGPNSALV QQLIKDLPDE VRERWETFCT SSLGETNKRN TVDLAFSDYQ MQQMTSNFID 490 500 510 520 530 540 QFGFNDEKFA DQDDIGNVSF DRVSDINFTL NTNESGNIAL FEACCKERIQ QFDDGGSDEE 550 560 570 580 590 600 DIWEEKHIAF TPESQRRSSS GSTDSEESTD SEEEDGAKQD LFEPSSANTE DKMEVDLSEP 610 620 630 640 650 660 PNWSANFDVP METTHGAPLD SVGSDVWSTE EPMPTKETGW ASFSEFTSSL STKDSLRSNS 670 680 690 700 710 720 PVEMETSTEP MDPLTPSAAA LAVQPEAAGS VAMEASSDGE EDAESTDKVT ETVMNGGMKE 730 740 750 760 770 780 TLSLTVDAKT ETAVFKSEEG KLSTSQDAAC KDAEECPETA EAKCAAPRPP SSSPEQSGVE 790 IPALPGQWSQ Q
	Isoform 4 (A) (C11orf23a) (SAPLa) [UniParc]. Checksum: AC5BEE22285932F4	FASTA	793	88,952
	10 20 30 40 50 60 MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK AECLEDLVSF 70 80 90 100 110 120 IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE SLLMKLYSFL LNDSPLNPLL 130 140 150 160 170 180 ASFFSKVLSI LISRKPEQIV DFLKKKHDFV DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ 190 200 210 220 230 240 DVLNWLNEEK IIQRLVEIVH PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA 250 260 270 280 290 300 TLEKQEIIEQ LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS 310 320 330 340 350 360 VNKSVLEAIR GRLGSFHELL LEPPKNMFFK YTWNNFLHTQ VEICIALILA SPFENTENAT 370 380 390 400 410 420 ITDQDSTGDN LLLKHLFQKC QLIERILEAW EMNEKKQAEG GRRHGYMGHL TRIANCIVHS 430 440 450 460 470 480 TDKGPNSALV QQLIKDLPDE VRERWETFCT SSLGETNKRN TVDLAFSDYQ MQQMTSNFID 490 500 510 520 530 540 QFGFNDEKFA DQDDIGNVSF DRVSDINFTL NTNESGNIAL FEACCKERIQ QFDDGGSDEE 550 560 570 580 590 600 DIWEEKHIAF TPESQRRSSS GSTDSEESTD SEEEDGAKQD LFEPSSANTE DKMEVDLSEP 610 620 630 640 650 660 PNWSANFDVP METTHGAPLD SVGSDVWSTE EPMPTKETGW ASFSEFTSSL STKDSLRSNS 670 680 690 700 710 720 PVEMETSTEP MDPLTPSAAA LAVQPEAAGS VAMEASSDGE EDAESTDKVT ETVMNGGMKE 730 740 750 760 770 780 TLSLTVDAKT ETAVFKSEEG KLSTSQDAAC KDAEECPETA EAKCAAPRPP SSSPEQRTGQ 790 PSAPGDTSVN GPV
	Isoform 5 [UniParc]. Checksum: E0AE6571756853C1	FASTA	879	98,485
	10 20 30 40 50 60 MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK AECLEDLVSF 70 80 90 100 110 120 IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE SLLMKLYSFL LNDSPLNPLL 130 140 150 160 170 180 ASFFSKVLSI LISRKPEQIV DFLKKKHDFV DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ 190 200 210 220 230 240 DVLNWLNEEK IIQRLVEIVH PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA 250 260 270 280 290 300 TLEKQEIIEQ LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS 310 320 330 340 350 360 VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL ISSLLQTNTS 370 380 390 400 410 420 SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL ASPFENTENA TITDQDSTGD 430 440 450 460 470 480 NLLLKHLFQK CQLIERILEA WEMNEKKQAE GGRRHGYMGH LTRIANCIVH STDKGPNSAL 490 500 510 520 530 540 VQQLIKDLPD EVRERWETFC TSSLGETNKR NTVDLVTTCH IHSSSDDEID FKETGFSQDS 550 560 570 580 590 600 SLQQAFSDYQ MQQMTSNFID QFGFNDEKFA DQDDIGNVSF DRVSDINFTL NTNESGNIAL 610 620 630 640 650 660 FEACCKERIQ QFDDGGSDEE DIWEEKHIAF TPESQRRSSS GSTDSEESTD SEEEDGAKQD 670 680 690 700 710 720 LFEPSSANTE DKMEVDLSEP PNWSANFDVP METTHGAPLD SVGSDVWSTE EPMPTKETGW 730 740 750 760 770 780 ASFSEFTSSL STKDSLRSNS PVEMETSTEP MDPLTPSAAA LAVQPEAAGS VAMEASSDGE 790 800 810 820 830 840 EDAESTDKVT ETVMNGGMKE TLSLTVDAKT ETAVFKRVLK SYREEGKLST SQDAACKDAE 850 860 870 ECPETAEAKC AAPRPPSSSP EQRTGQPSAP GDTSVNGPV
	Isoform 6 [UniParc]. Checksum: ADB89AA9C567C580	FASTA	844	94,445
	10 20 30 40 50 60 MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK AECLEDLVSF 70 80 90 100 110 120 IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE SLLMKLYSFL LNDSPLNPLL 130 140 150 160 170 180 ASFFSKVLSI LISRKPEQIV DFLKKKHDFV DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ 190 200 210 220 230 240 DVLNWLNEEK IIQRLVEIVH PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA 250 260 270 280 290 300 TLEKQEIIEQ LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS 310 320 330 340 350 360 VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL ISSLLQTNTS 370 380 390 400 410 420 SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL ASPFENTENA TITDQDSTGD 430 440 450 460 470 480 NLLLKHLFQK CQLIERILEA WEMNEKKQAE GGRRHGYMGH LTRIANCIVH STDKGPNSAL 490 500 510 520 530 540 VQQLIKDLPD EVRERWETFC TSSLGETNKR NTVDLAFSDY QMQQMTSNFI DQFGFNDEKF 550 560 570 580 590 600 ADQDDIGNVS FDRVSDINFT LNTNESGNIA LFEACCKERI QQFDDGGSDE EDIWEEKHIA 610 620 630 640 650 660 FTPESQRRSS SGSTDSEEST DSEEEDGAKQ DLFEPSSANT EDKMEVDLSE PPNWSANFDV 670 680 690 700 710 720 PMETTHGAPL DSVGSDVWST EEPMPTKETG WASFSEFTSS LSTKDSLRSN SPVEMETSTE 730 740 750 760 770 780 PMDPLTPSAA ALAVQPEAAG SVAMEASSDG EEDAESTDKV TETVMNGGMK ETLSLTVDAK 790 800 810 820 830 840 TETAVFKSEE GKLSTSQDAA CKDAEECPET AEAKCAAPRP PSSSPEQRTG QPSAPGDTSV NGPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13." Twells R.C.J., Metzker M.L., Brown S.D., Cox R., Garey C., Hammond H., Hey P.J., Levy E., Nakagawa Y., Philips M.S., Todd J.A., Hess J.F. Genomics 72:231-242(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), FUNCTION, TISSUE SPECIFICITY.
[2]	Guergnon J., Stefansson B., Brautigan D.L. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SEQUENCE REVISION.
[3]	"Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon." Stefansson B., Brautigan D.L. J. Biol. Chem. 281:22624-22634(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 226-873 (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-873 (ISOFORMS 1/2/4/6). Tissue: Colon carcinoma, Melanoma and Seminal plasma.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 650-873 (ISOFORMS 1/2/4/6). Tissue: Muscle.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 221-873 (ISOFORM 1). Tissue: Placenta and Testis.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-579, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains." Stefansson B., Ohama T., Daugherty A.E., Brautigan D.L. Biochemistry 47:1442-1451(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PPP6C AND ANKRD28.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-722, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617, MASS SPECTROMETRY.
[14]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-579 AND SER-617, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[15]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-579 AND SER-617, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-579 AND SER-617, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF264779 mRNA. Translation: AAG36934.1. AF264780 mRNA. Translation: AAG36935.1. DQ111954 mRNA. Translation: AAZ99639.2. Different initiation. AB046778 mRNA. Translation: BAB13384.2. Different initiation. AL834471 mRNA. Translation: CAD39130.1. CR749815 mRNA. Translation: CAH18675.1. CR933658 mRNA. Translation: CAI45957.1. BC007738 mRNA. Translation: AAH07738.2. BC105933 mRNA. Translation: AAI05934.1. BC105934 mRNA. Translation: AAI05935.1. BC107599 mRNA. Translation: AAI07600.1. AK001920 mRNA. Translation: BAA91978.1. Different initiation. AK057250 mRNA. Translation: BAB71396.1. Different initiation.
IPI	IPI00019540. IPI00030624. IPI00719345. IPI00719553. IPI00719725. IPI00719821.
RefSeq	NP_001157632.1. NM_001164160.1. NP_001157633.1. NM_001164161.1. NP_001157634.1. NM_001164162.1. NP_001157635.1. NM_001164163.1. NP_001157636.1. NM_001164164.1. NP_060782.2. NM_018312.4.
UniGene	Hs.503022.
3D structure databases
ProteinModelPortal	Q5H9R7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5H9R7. 11 interactions.
PTM databases
PhosphoSite	Q5H9R7.
Polymorphism databases
DMDM	88941982.
Proteomic databases
PaxDb	Q5H9R7.
PRIDE	Q5H9R7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265636; ENSP00000265636; ENSG00000110075. ENST00000393800; ENSP00000377389; ENSG00000110075. ENST00000393801; ENSP00000377390; ENSG00000110075. ENST00000524845; ENSP00000431415; ENSG00000110075. ENST00000524904; ENSP00000433058; ENSG00000110075. ENST00000529710; ENSP00000437329; ENSG00000110075.
GeneID	55291.
KEGG	hsa:55291.
UCSC	uc001onu.3. human. uc001onv.3. human. uc001onw.3. human. uc001onx.3. human. uc001ony.4. human. uc009ysh.3. human.
Organism-specific databases
CTD	55291.
GeneCards	GC11P068229.
HGNC	HGNC:1173. PPP6R3.
HPA	CAB017183.
MIM	610879. gene.
neXtProt	NX_Q5H9R7.
PharmGKB	PA25487.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG303042.
HOVERGEN	HBG069733.
KO	K15501.
OMA	PAKETGW.
Gene expression databases
ArrayExpress	Q5H9R7.
Bgee	Q5H9R7.
Genevestigator	Q5H9R7.
Family and domain databases
InterPro	IPR007587. SAPS. [Graphical view]
PANTHER	PTHR12634. PTHR12634. 1 hit.
Pfam	PF04499. SAPS. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PPP6R3. human.
GenomeRNAi	55291.
NextBio	59478.
SOURCE	Search...

Entry information

Entry name

PP6R3_HUMAN

Accession

Primary (citable) accession number: Q5H9R7
Secondary accession number(s): Q3B7I1 , Q3I4Y0, Q3KR35, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.