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Q5H9R4

- ARMX4_HUMAN

UniProt

Q5H9R4 - ARMX4_HUMAN

Protein

Armadillo repeat-containing X-linked protein 4

Gene

ARMCX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Armadillo repeat-containing X-linked protein 4
    Gene namesi
    Name:ARMCX4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:28615. ARMCX4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Armadillo repeat-containing X-linked protein 4PRO_0000191370Add
    BLAST

    Proteomic databases

    PRIDEiQ5H9R4.

    PTM databases

    PhosphoSiteiQ5H9R4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5H9R4.
    BgeeiQ5H9R4.
    CleanExiHS_ARMCX4.
    GenevestigatoriQ5H9R4.

    Organism-specific databases

    HPAiHPA000429.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000404304.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5H9R4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei111 – 12818HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000013182.
    InParanoidiQ5H9R4.
    PhylomeDBiQ5H9R4.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5H9R4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAAGLKITG SKETKRRLLL ISIDWSRDLM NLCIYFRVYC QEKQEERREL    50
    PRIITGPPPE AAVVAFEWLK TSTLTGLHPQ LPLSLPQPEC ALPYLVRAFS 100
    RGDYMGRIQE VGWVTAGLVI WAGTCYYIYK FTKGRAQSVR TLARNGSTVK 150
    METVVGVQSQ TLAINEAEIK TKPQVEIGAE TGARSGPRAE VETKATAIAI 200
    HRANSQAKAM VGAEPETQSE SKVVAGTLVM TEAVTLTEVK AKAREVAMKE 250
    AVTQTDAEAG KIVKKEAVTQ TKAKAWALVA KTEAKREAMT QTKAETHILA 300
    EKETEINRVM VTQSETLAVP REVAKMGATN KTGIVDETKT RALEETVLIP 350
    RAFPSKNASC 360
    Length:360
    Mass (Da):39,406
    Last modified:December 20, 2005 - v2
    Checksum:iAFD1BF07D758CC06
    GO
    Isoform 2 (identifier: Q5H9R4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-37: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:348
    Mass (Da):37,893
    Checksum:iB1F7B37580575021
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 843PLS → RLC in CAI45960. (PubMed:17974005)Curated
    Sequence conflicti357 – 3571N → D in BAC04910. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti188 – 1881R → G.2 Publications
    Corresponds to variant rs5951332 [ dbSNP | Ensembl ].
    VAR_024761

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei26 – 3712Missing in isoform 2. 1 PublicationVSP_016747Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096955 mRNA. Translation: BAC04910.1.
    AK126987 mRNA. Translation: BAG54416.1.
    AK292543 mRNA. Translation: BAF85232.1.
    CR933662 mRNA. Translation: CAI45960.1.
    Z68873 Genomic DNA. No translation available.
    CH471115 Genomic DNA. Translation: EAX02869.1.
    UniGeneiHs.729062.

    Genome annotation databases

    EnsembliENST00000354842; ENSP00000423927; ENSG00000196440. [Q5H9R4-2]
    ENST00000433011; ENSP00000424452; ENSG00000196440. [Q5H9R4-1]
    ENST00000452188; ENSP00000425302; ENSG00000196440. [Q5H9R4-1]
    ENST00000455331; ENSP00000423440; ENSG00000196440. [Q5H9R4-2]

    Polymorphism databases

    DMDMi84027758.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096955 mRNA. Translation: BAC04910.1 .
    AK126987 mRNA. Translation: BAG54416.1 .
    AK292543 mRNA. Translation: BAF85232.1 .
    CR933662 mRNA. Translation: CAI45960.1 .
    Z68873 Genomic DNA. No translation available.
    CH471115 Genomic DNA. Translation: EAX02869.1 .
    UniGenei Hs.729062.

    3D structure databases

    ProteinModelPortali Q5H9R4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000404304.

    PTM databases

    PhosphoSitei Q5H9R4.

    Polymorphism databases

    DMDMi 84027758.

    Proteomic databases

    PRIDEi Q5H9R4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354842 ; ENSP00000423927 ; ENSG00000196440 . [Q5H9R4-2 ]
    ENST00000433011 ; ENSP00000424452 ; ENSG00000196440 . [Q5H9R4-1 ]
    ENST00000452188 ; ENSP00000425302 ; ENSG00000196440 . [Q5H9R4-1 ]
    ENST00000455331 ; ENSP00000423440 ; ENSG00000196440 . [Q5H9R4-2 ]

    Organism-specific databases

    GeneCardsi GC0XP100673.
    H-InvDB HIX0020542.
    HGNCi HGNC:28615. ARMCX4.
    HPAi HPA000429.
    neXtProti NX_Q5H9R4.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000013182.
    InParanoidi Q5H9R4.
    PhylomeDBi Q5H9R4.

    Miscellaneous databases

    ChiTaRSi ARMCX4. human.
    PROi Q5H9R4.

    Gene expression databases

    ArrayExpressi Q5H9R4.
    Bgeei Q5H9R4.
    CleanExi HS_ARMCX4.
    Genevestigatori Q5H9R4.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-188.
      Tissue: Brain, Small intestine and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-188.
      Tissue: Fetal kidney.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiARMX4_HUMAN
    AccessioniPrimary (citable) accession number: Q5H9R4
    Secondary accession number(s): A8K928
    , B3KXA4, Q5H9K8, Q8N8D6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3