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Q5H9R4

- ARMX4_HUMAN

UniProt

Q5H9R4 - ARMX4_HUMAN

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Protein

Armadillo repeat-containing X-linked protein 4

Gene

ARMCX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 4
Gene namesi
Name:ARMCX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:28615. ARMCX4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei111 – 12818HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Armadillo repeat-containing X-linked protein 4PRO_0000191370Add
BLAST

Proteomic databases

PRIDEiQ5H9R4.

PTM databases

PhosphoSiteiQ5H9R4.

Expressioni

Gene expression databases

BgeeiQ5H9R4.
CleanExiHS_ARMCX4.
ExpressionAtlasiQ5H9R4. baseline and differential.
GenevestigatoriQ5H9R4.

Organism-specific databases

HPAiHPA000429.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000404304.

Structurei

3D structure databases

ProteinModelPortaliQ5H9R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000007340.
HOGENOMiHOG000013182.
InParanoidiQ5H9R4.
PhylomeDBiQ5H9R4.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5H9R4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAAGLKITG SKETKRRLLL ISIDWSRDLM NLCIYFRVYC QEKQEERREL
60 70 80 90 100
PRIITGPPPE AAVVAFEWLK TSTLTGLHPQ LPLSLPQPEC ALPYLVRAFS
110 120 130 140 150
RGDYMGRIQE VGWVTAGLVI WAGTCYYIYK FTKGRAQSVR TLARNGSTVK
160 170 180 190 200
METVVGVQSQ TLAINEAEIK TKPQVEIGAE TGARSGPRAE VETKATAIAI
210 220 230 240 250
HRANSQAKAM VGAEPETQSE SKVVAGTLVM TEAVTLTEVK AKAREVAMKE
260 270 280 290 300
AVTQTDAEAG KIVKKEAVTQ TKAKAWALVA KTEAKREAMT QTKAETHILA
310 320 330 340 350
EKETEINRVM VTQSETLAVP REVAKMGATN KTGIVDETKT RALEETVLIP
360
RAFPSKNASC
Length:360
Mass (Da):39,406
Last modified:December 20, 2005 - v2
Checksum:iAFD1BF07D758CC06
GO
Isoform 2 (identifier: Q5H9R4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-37: Missing.

Note: No experimental confirmation available.

Show »
Length:348
Mass (Da):37,893
Checksum:iB1F7B37580575021
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 843PLS → RLC in CAI45960. (PubMed:17974005)Curated
Sequence conflicti357 – 3571N → D in BAC04910. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti188 – 1881R → G.2 Publications
Corresponds to variant rs5951332 [ dbSNP | Ensembl ].
VAR_024761

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 3712Missing in isoform 2. 1 PublicationVSP_016747Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096955 mRNA. Translation: BAC04910.1.
AK126987 mRNA. Translation: BAG54416.1.
AK292543 mRNA. Translation: BAF85232.1.
CR933662 mRNA. Translation: CAI45960.1.
Z68873 Genomic DNA. No translation available.
CH471115 Genomic DNA. Translation: EAX02869.1.
UniGeneiHs.729062.

Genome annotation databases

EnsembliENST00000354842; ENSP00000423927; ENSG00000196440. [Q5H9R4-2]
ENST00000433011; ENSP00000424452; ENSG00000196440. [Q5H9R4-1]
ENST00000452188; ENSP00000425302; ENSG00000196440. [Q5H9R4-1]
ENST00000455331; ENSP00000423440; ENSG00000196440. [Q5H9R4-2]

Polymorphism databases

DMDMi84027758.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096955 mRNA. Translation: BAC04910.1 .
AK126987 mRNA. Translation: BAG54416.1 .
AK292543 mRNA. Translation: BAF85232.1 .
CR933662 mRNA. Translation: CAI45960.1 .
Z68873 Genomic DNA. No translation available.
CH471115 Genomic DNA. Translation: EAX02869.1 .
UniGenei Hs.729062.

3D structure databases

ProteinModelPortali Q5H9R4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000404304.

PTM databases

PhosphoSitei Q5H9R4.

Polymorphism databases

DMDMi 84027758.

Proteomic databases

PRIDEi Q5H9R4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354842 ; ENSP00000423927 ; ENSG00000196440 . [Q5H9R4-2 ]
ENST00000433011 ; ENSP00000424452 ; ENSG00000196440 . [Q5H9R4-1 ]
ENST00000452188 ; ENSP00000425302 ; ENSG00000196440 . [Q5H9R4-1 ]
ENST00000455331 ; ENSP00000423440 ; ENSG00000196440 . [Q5H9R4-2 ]

Organism-specific databases

GeneCardsi GC0XP100673.
H-InvDB HIX0020542.
HGNCi HGNC:28615. ARMCX4.
HPAi HPA000429.
neXtProti NX_Q5H9R4.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000007340.
HOGENOMi HOG000013182.
InParanoidi Q5H9R4.
PhylomeDBi Q5H9R4.

Miscellaneous databases

ChiTaRSi ARMCX4. human.
PROi Q5H9R4.

Gene expression databases

Bgeei Q5H9R4.
CleanExi HS_ARMCX4.
ExpressionAtlasi Q5H9R4. baseline and differential.
Genevestigatori Q5H9R4.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-188.
    Tissue: Brain, Small intestine and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-188.
    Tissue: Fetal kidney.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiARMX4_HUMAN
AccessioniPrimary (citable) accession number: Q5H9R4
Secondary accession number(s): A8K928
, B3KXA4, Q5H9K8, Q8N8D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3