ID   TCAL5_HUMAN             Reviewed;         206 AA.
AC   Q5H9L2; A2RUJ4;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   24-JAN-2024, entry version 132.
DE   RecName: Full=Transcription elongation factor A protein-like 5;
DE            Short=TCEA-like protein 5;
DE   AltName: Full=Transcription elongation factor S-II protein-like 5;
GN   Name=TCEAL5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q5H9L2; P43354: NR4A2; NbExp=2; IntAct=EBI-2681773, EBI-2681738;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TFS-II family. TFA subfamily. {ECO:0000305}.
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DR   EMBL; Z68694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471190; EAW54717.1; -; Genomic_DNA.
DR   EMBL; BC132922; AAI32923.1; -; mRNA.
DR   EMBL; BC132924; AAI32925.1; -; mRNA.
DR   CCDS; CCDS35356.1; -.
DR   RefSeq; NP_001012997.1; NM_001012979.2.
DR   AlphaFoldDB; Q5H9L2; -.
DR   SMR; Q5H9L2; -.
DR   BioGRID; 131070; 15.
DR   IntAct; Q5H9L2; 4.
DR   STRING; 9606.ENSP00000361765; -.
DR   iPTMnet; Q5H9L2; -.
DR   PhosphoSitePlus; Q5H9L2; -.
DR   BioMuta; TCEAL5; -.
DR   DMDM; 74762182; -.
DR   EPD; Q5H9L2; -.
DR   jPOST; Q5H9L2; -.
DR   MassIVE; Q5H9L2; -.
DR   MaxQB; Q5H9L2; -.
DR   PaxDb; 9606-ENSP00000361765; -.
DR   PeptideAtlas; Q5H9L2; -.
DR   ProteomicsDB; 62895; -.
DR   Pumba; Q5H9L2; -.
DR   Antibodypedia; 71662; 30 antibodies from 14 providers.
DR   DNASU; 340543; -.
DR   Ensembl; ENST00000372680.2; ENSP00000361765.1; ENSG00000204065.3.
DR   GeneID; 340543; -.
DR   KEGG; hsa:340543; -.
DR   MANE-Select; ENST00000372680.2; ENSP00000361765.1; NM_001012979.3; NP_001012997.1.
DR   UCSC; uc004ejz.3; human.
DR   AGR; HGNC:22282; -.
DR   CTD; 340543; -.
DR   GeneCards; TCEAL5; -.
DR   HGNC; HGNC:22282; TCEAL5.
DR   HPA; ENSG00000204065; Tissue enhanced (brain, pituitary gland, testis).
DR   neXtProt; NX_Q5H9L2; -.
DR   OpenTargets; ENSG00000204065; -.
DR   PharmGKB; PA134950668; -.
DR   VEuPathDB; HostDB:ENSG00000204065; -.
DR   eggNOG; ENOG502RKY0; Eukaryota.
DR   GeneTree; ENSGT00950000183164; -.
DR   HOGENOM; CLU_078412_1_0_1; -.
DR   InParanoid; Q5H9L2; -.
DR   OMA; PREKLMP; -.
DR   OrthoDB; 4741058at2759; -.
DR   PhylomeDB; Q5H9L2; -.
DR   TreeFam; TF336871; -.
DR   PathwayCommons; Q5H9L2; -.
DR   SignaLink; Q5H9L2; -.
DR   BioGRID-ORCS; 340543; 7 hits in 703 CRISPR screens.
DR   GenomeRNAi; 340543; -.
DR   Pharos; Q5H9L2; Tdark.
DR   PRO; PR:Q5H9L2; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q5H9L2; Protein.
DR   Bgee; ENSG00000204065; Expressed in superior frontal gyrus and 93 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021156; TF_A-like/BEX.
DR   Pfam; PF04538; BEX; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..206
FT                   /note="Transcription elongation factor A protein-like 5"
FT                   /id="PRO_0000239211"
FT   REGION          1..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..88
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..168
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..206
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   206 AA;  23307 MW;  CCDB6A1ACCCE3BAD CRC64;
     MEKLYKENEG KPENERNLES EGKPEDEGST EDEGKSDEEE KPDMEGKTEC EGKREDEGEP
     GDEGQLEDEG NQEKQGKSEG EDKPQSEGKP ASQAKPESQP RAAEKRPAED YVPRKAKRKT
     DRGTDDSPKD SQEDLQERHL SSEEMMRECG DVSRAQEELR KKQKMGGFHW MQRDVQDPFA
     PRGQRGVRGV RGGGRGQKDL EDVPYV
//