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Protein

Transcription elongation factor A protein-like 5

Gene

TCEAL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein-like 5
Short name:
TCEA-like protein 5
Alternative name(s):
Transcription elongation factor S-II protein-like 5
Gene namesi
Name:TCEAL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:22282. TCEAL5.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950668.

Polymorphism and mutation databases

BioMutaiTCEAL5.
DMDMi74762182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Transcription elongation factor A protein-like 5PRO_0000239211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5H9L2.
PRIDEiQ5H9L2.

PTM databases

PhosphoSiteiQ5H9L2.

Expressioni

Gene expression databases

BgeeiQ5H9L2.
CleanExiHS_TCEAL5.
GenevestigatoriQ5H9L2.

Organism-specific databases

HPAiHPA045564.
HPA058982.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A2P433542EBI-2681773,EBI-2681738

Protein-protein interaction databases

BioGridi131070. 2 interactions.
IntActiQ5H9L2. 4 interactions.
STRINGi9606.ENSP00000361765.

Structurei

3D structure databases

ProteinModelPortaliQ5H9L2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 8180Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Phylogenomic databases

eggNOGiNOG85288.
GeneTreeiENSGT00510000046867.
HOGENOMiHOG000231342.
HOVERGENiHBG055896.
InParanoidiQ5H9L2.
OMAiPENKGRA.
OrthoDBiEOG7QNVNM.
PhylomeDBiQ5H9L2.
TreeFamiTF336871.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
IPR010370. TFA.
[Graphical view]
PANTHERiPTHR14754. PTHR14754. 1 hit.
PfamiPF04538. BEX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5H9L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLYKENEG KPENERNLES EGKPEDEGST EDEGKSDEEE KPDMEGKTEC
60 70 80 90 100
EGKREDEGEP GDEGQLEDEG NQEKQGKSEG EDKPQSEGKP ASQAKPESQP
110 120 130 140 150
RAAEKRPAED YVPRKAKRKT DRGTDDSPKD SQEDLQERHL SSEEMMRECG
160 170 180 190 200
DVSRAQEELR KKQKMGGFHW MQRDVQDPFA PRGQRGVRGV RGGGRGQKDL

EDVPYV
Length:206
Mass (Da):23,307
Last modified:February 15, 2005 - v1
Checksum:iCCDB6A1ACCCE3BAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68694 Genomic DNA. Translation: CAI41976.1.
CH471190 Genomic DNA. Translation: EAW54717.1.
BC132922 mRNA. Translation: AAI32923.1.
BC132924 mRNA. Translation: AAI32925.1.
CCDSiCCDS35356.1.
RefSeqiNP_001012997.1. NM_001012979.2.
UniGeneiHs.403462.

Genome annotation databases

EnsembliENST00000372680; ENSP00000361765; ENSG00000204065.
GeneIDi340543.
KEGGihsa:340543.
UCSCiuc004ejz.2. human.

Polymorphism and mutation databases

BioMutaiTCEAL5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68694 Genomic DNA. Translation: CAI41976.1.
CH471190 Genomic DNA. Translation: EAW54717.1.
BC132922 mRNA. Translation: AAI32923.1.
BC132924 mRNA. Translation: AAI32925.1.
CCDSiCCDS35356.1.
RefSeqiNP_001012997.1. NM_001012979.2.
UniGeneiHs.403462.

3D structure databases

ProteinModelPortaliQ5H9L2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131070. 2 interactions.
IntActiQ5H9L2. 4 interactions.
STRINGi9606.ENSP00000361765.

PTM databases

PhosphoSiteiQ5H9L2.

Polymorphism and mutation databases

BioMutaiTCEAL5.
DMDMi74762182.

Proteomic databases

PaxDbiQ5H9L2.
PRIDEiQ5H9L2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372680; ENSP00000361765; ENSG00000204065.
GeneIDi340543.
KEGGihsa:340543.
UCSCiuc004ejz.2. human.

Organism-specific databases

CTDi340543.
GeneCardsiGC0XM102528.
HGNCiHGNC:22282. TCEAL5.
HPAiHPA045564.
HPA058982.
neXtProtiNX_Q5H9L2.
PharmGKBiPA134950668.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85288.
GeneTreeiENSGT00510000046867.
HOGENOMiHOG000231342.
HOVERGENiHBG055896.
InParanoidiQ5H9L2.
OMAiPENKGRA.
OrthoDBiEOG7QNVNM.
PhylomeDBiQ5H9L2.
TreeFamiTF336871.

Miscellaneous databases

GenomeRNAii340543.
NextBioi97916.
PROiQ5H9L2.

Gene expression databases

BgeeiQ5H9L2.
CleanExiHS_TCEAL5.
GenevestigatoriQ5H9L2.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
IPR010370. TFA.
[Graphical view]
PANTHERiPTHR14754. PTHR14754. 1 hit.
PfamiPF04538. BEX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTCAL5_HUMAN
AccessioniPrimary (citable) accession number: Q5H9L2
Secondary accession number(s): A2RUJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 15, 2005
Last modified: April 29, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.