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Q5H9L2

- TCAL5_HUMAN

UniProt

Q5H9L2 - TCAL5_HUMAN

Protein

Transcription elongation factor A protein-like 5

Gene

TCEAL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription elongation factor A protein-like 5
    Short name:
    TCEA-like protein 5
    Alternative name(s):
    Transcription elongation factor S-II protein-like 5
    Gene namesi
    Name:TCEAL5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:22282. TCEAL5.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134950668.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 206206Transcription elongation factor A protein-like 5PRO_0000239211Add
    BLAST

    Proteomic databases

    PaxDbiQ5H9L2.
    PRIDEiQ5H9L2.

    PTM databases

    PhosphoSiteiQ5H9L2.

    Expressioni

    Gene expression databases

    BgeeiQ5H9L2.
    CleanExiHS_TCEAL5.
    GenevestigatoriQ5H9L2.

    Organism-specific databases

    HPAiHPA045564.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NR4A2P433542EBI-2681773,EBI-2681738

    Protein-protein interaction databases

    BioGridi131070. 2 interactions.
    IntActiQ5H9L2. 4 interactions.
    STRINGi9606.ENSP00000361765.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5H9L2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 8180Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TFS-II family. TFA subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG85288.
    HOGENOMiHOG000231342.
    HOVERGENiHBG055896.
    InParanoidiQ5H9L2.
    OMAiPENKGRA.
    OrthoDBiEOG7QNVNM.
    PhylomeDBiQ5H9L2.
    TreeFamiTF336871.

    Family and domain databases

    InterProiIPR021156. TF_A-like/BEX-like.
    IPR010370. TFA.
    [Graphical view]
    PANTHERiPTHR14754. PTHR14754. 1 hit.
    PfamiPF04538. BEX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5H9L2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKLYKENEG KPENERNLES EGKPEDEGST EDEGKSDEEE KPDMEGKTEC    50
    EGKREDEGEP GDEGQLEDEG NQEKQGKSEG EDKPQSEGKP ASQAKPESQP 100
    RAAEKRPAED YVPRKAKRKT DRGTDDSPKD SQEDLQERHL SSEEMMRECG 150
    DVSRAQEELR KKQKMGGFHW MQRDVQDPFA PRGQRGVRGV RGGGRGQKDL 200
    EDVPYV 206
    Length:206
    Mass (Da):23,307
    Last modified:February 15, 2005 - v1
    Checksum:iCCDB6A1ACCCE3BAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z68694 Genomic DNA. Translation: CAI41976.1.
    CH471190 Genomic DNA. Translation: EAW54717.1.
    BC132922 mRNA. Translation: AAI32923.1.
    BC132924 mRNA. Translation: AAI32925.1.
    CCDSiCCDS35356.1.
    RefSeqiNP_001012997.1. NM_001012979.2.
    UniGeneiHs.403462.

    Genome annotation databases

    EnsembliENST00000372680; ENSP00000361765; ENSG00000204065.
    GeneIDi340543.
    KEGGihsa:340543.
    UCSCiuc004ejz.2. human.

    Polymorphism databases

    DMDMi74762182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z68694 Genomic DNA. Translation: CAI41976.1 .
    CH471190 Genomic DNA. Translation: EAW54717.1 .
    BC132922 mRNA. Translation: AAI32923.1 .
    BC132924 mRNA. Translation: AAI32925.1 .
    CCDSi CCDS35356.1.
    RefSeqi NP_001012997.1. NM_001012979.2.
    UniGenei Hs.403462.

    3D structure databases

    ProteinModelPortali Q5H9L2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131070. 2 interactions.
    IntActi Q5H9L2. 4 interactions.
    STRINGi 9606.ENSP00000361765.

    PTM databases

    PhosphoSitei Q5H9L2.

    Polymorphism databases

    DMDMi 74762182.

    Proteomic databases

    PaxDbi Q5H9L2.
    PRIDEi Q5H9L2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372680 ; ENSP00000361765 ; ENSG00000204065 .
    GeneIDi 340543.
    KEGGi hsa:340543.
    UCSCi uc004ejz.2. human.

    Organism-specific databases

    CTDi 340543.
    GeneCardsi GC0XM102528.
    HGNCi HGNC:22282. TCEAL5.
    HPAi HPA045564.
    neXtProti NX_Q5H9L2.
    PharmGKBi PA134950668.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85288.
    HOGENOMi HOG000231342.
    HOVERGENi HBG055896.
    InParanoidi Q5H9L2.
    OMAi PENKGRA.
    OrthoDBi EOG7QNVNM.
    PhylomeDBi Q5H9L2.
    TreeFami TF336871.

    Miscellaneous databases

    GenomeRNAii 340543.
    NextBioi 97916.
    PROi Q5H9L2.

    Gene expression databases

    Bgeei Q5H9L2.
    CleanExi HS_TCEAL5.
    Genevestigatori Q5H9L2.

    Family and domain databases

    InterProi IPR021156. TF_A-like/BEX-like.
    IPR010370. TFA.
    [Graphical view ]
    PANTHERi PTHR14754. PTHR14754. 1 hit.
    Pfami PF04538. BEX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiTCAL5_HUMAN
    AccessioniPrimary (citable) accession number: Q5H9L2
    Secondary accession number(s): A2RUJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3