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Protein

Zinc finger matrin-type protein 1

Gene

ZMAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri56 – 8631Matrin-type 1Add
BLAST
Zinc fingeri121 – 15131Matrin-type 2Add
BLAST
Zinc fingeri172 – 20635Matrin-type 3Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger matrin-type protein 1
Gene namesi
Name:ZMAT1
Synonyms:KIAA1789
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29377. ZMAT1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880461.

Polymorphism and mutation databases

DMDMi74762181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Zinc finger matrin-type protein 1PRO_0000311348Add
BLAST

Proteomic databases

PaxDbiQ5H9K5.
PRIDEiQ5H9K5.

PTM databases

iPTMnetiQ5H9K5.
PhosphoSiteiQ5H9K5.

Expressioni

Gene expression databases

BgeeiQ5H9K5.
CleanExiHS_ZMAT1.
GenevisibleiQ5H9K5. HS.

Organism-specific databases

HPAiHPA012827.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124094. 8 interactions.
IntActiQ5H9K5. 5 interactions.
STRINGi9606.ENSP00000361868.

Structurei

3D structure databases

ProteinModelPortaliQ5H9K5.
SMRiQ5H9K5. Positions 47-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 matrin-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri56 – 8631Matrin-type 1Add
BLAST
Zinc fingeri121 – 15131Matrin-type 2Add
BLAST
Zinc fingeri172 – 20635Matrin-type 3Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHK5. Eukaryota.
ENOG410Y3E0. LUCA.
HOGENOMiHOG000113259.
HOVERGENiHBG099654.
InParanoidiQ5H9K5.
OrthoDBiEOG7SJD60.
PhylomeDBiQ5H9K5.
TreeFamiTF337202.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5H9K5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESCSVTRLE CSGAISAHCS LHLPGSSDSP ASASQIAGTT DAIWNEQEKA
60 70 80 90 100
ELFTDKFCQV CGVMLQFESQ RISHYEGEKH AQNVSFYFQM HGEQNEVPGK
110 120 130 140 150
KMKMHVENFQ VHRYEGVDKN KFCDLCNMMF SSPLIAQSHY VGKVHAKKLK
160 170 180 190 200
QLMEEHDQAS PSGFQPEMAF SMRTYVCHIC SIAFTSLDMF RSHMQGSEHQ
210 220 230 240 250
IKESIVINLV KNSRKTQDSY QNECADYINV QKARGLEAKT CFRKMEESSL
260 270 280 290 300
ETRRYREVVD SRPRHRMFEQ RLPFETFRTY AAPYNISQAM EKQLPHSKKT
310 320 330 340 350
YDSFQDELED YIKVQKARGL DPKTCFRKMR ENSVDTHGYR EMVDSGPRSR
360 370 380 390 400
MCEQRFSHEA SQTYQRPYHI SPVESQLPQW LPTHSKRTYD SFQDELEDYI
410 420 430 440 450
KVQKARGLEP KTCFRKIGDS SVETHRNREM VDVRPRHRML EQKLPCETFQ
460 470 480 490 500
TYSGPYSISQ VVENQLPHCL PAHDSKQRLD SISYCQLTRD CFPEKPVPLS
510 520 530 540 550
LNQQENNSGS YSVESEVYKH LSSENNTADH QAGHKQKHQK RKRHLEEGKE
560 570 580 590 600
RPEKEQSKHK RKKSYEDTDL DKDKSIRQRK REEDRVKVSS GKLKHRKKKK
610 620 630
SHDVPSEKEE RKHRKEKKKS VEERTEEEML WDESILGF
Length:638
Mass (Da):74,755
Last modified:February 15, 2005 - v1
Checksum:iD35B4FC2D112A87F
GO
Isoform 2 (identifier: Q5H9K5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:467
Mass (Da):55,545
Checksum:i1E29A73FCA9AED95
GO

Sequence cautioni

The sequence BAB47418.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti214 – 2141R → K.
Corresponds to variant rs17282855 [ dbSNP | Ensembl ].
VAR_053766
Natural varianti536 – 5361Q → R.2 Publications
Corresponds to variant rs5944882 [ dbSNP | Ensembl ].
VAR_062159

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 171171Missing in isoform 2. 1 PublicationVSP_029533Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058692 mRNA. Translation: BAB47418.1. Different initiation.
Z69304, Z68868 Genomic DNA. Translation: CAI42009.1.
Z68868, Z69304 Genomic DNA. Translation: CAI42751.1.
AL831883 mRNA. Translation: CAD38564.1.
CCDSiCCDS35348.1. [Q5H9K5-1]
RefSeqiNP_001269329.1. NM_001282400.1.
NP_001269330.1. NM_001282401.1.
XP_006724774.1. XM_006724711.2.
XP_011529361.1. XM_011531059.1.
UniGeneiHs.496512.

Genome annotation databases

EnsembliENST00000372782; ENSP00000361868; ENSG00000166432.
ENST00000540921; ENSP00000437529; ENSG00000166432.
GeneIDi84460.
KEGGihsa:84460.
UCSCiuc011mrl.3. human. [Q5H9K5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058692 mRNA. Translation: BAB47418.1. Different initiation.
Z69304, Z68868 Genomic DNA. Translation: CAI42009.1.
Z68868, Z69304 Genomic DNA. Translation: CAI42751.1.
AL831883 mRNA. Translation: CAD38564.1.
CCDSiCCDS35348.1. [Q5H9K5-1]
RefSeqiNP_001269329.1. NM_001282400.1.
NP_001269330.1. NM_001282401.1.
XP_006724774.1. XM_006724711.2.
XP_011529361.1. XM_011531059.1.
UniGeneiHs.496512.

3D structure databases

ProteinModelPortaliQ5H9K5.
SMRiQ5H9K5. Positions 47-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124094. 8 interactions.
IntActiQ5H9K5. 5 interactions.
STRINGi9606.ENSP00000361868.

PTM databases

iPTMnetiQ5H9K5.
PhosphoSiteiQ5H9K5.

Polymorphism and mutation databases

DMDMi74762181.

Proteomic databases

PaxDbiQ5H9K5.
PRIDEiQ5H9K5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372782; ENSP00000361868; ENSG00000166432.
ENST00000540921; ENSP00000437529; ENSG00000166432.
GeneIDi84460.
KEGGihsa:84460.
UCSCiuc011mrl.3. human. [Q5H9K5-1]

Organism-specific databases

CTDi84460.
GeneCardsiZMAT1.
HGNCiHGNC:29377. ZMAT1.
HPAiHPA012827.
neXtProtiNX_Q5H9K5.
PharmGKBiPA134880461.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHK5. Eukaryota.
ENOG410Y3E0. LUCA.
HOGENOMiHOG000113259.
HOVERGENiHBG099654.
InParanoidiQ5H9K5.
OrthoDBiEOG7SJD60.
PhylomeDBiQ5H9K5.
TreeFamiTF337202.

Miscellaneous databases

ChiTaRSiZMAT1. human.
GenomeRNAii84460.
PROiQ5H9K5.

Gene expression databases

BgeeiQ5H9K5.
CleanExiHS_ZMAT1.
GenevisibleiQ5H9K5. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-536.
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 429-638, VARIANT ARG-536.
    Tissue: Brain.

Entry informationi

Entry nameiZMAT1_HUMAN
AccessioniPrimary (citable) accession number: Q5H9K5
Secondary accession number(s): Q8NDS3, Q96JN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.