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Protein

Zinc finger matrin-type protein 1

Gene

ZMAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri56 – 86Matrin-type 1Add BLAST31
Zinc fingeri121 – 151Matrin-type 2Add BLAST31
Zinc fingeri172 – 206Matrin-type 3Add BLAST35

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger matrin-type protein 1
Gene namesi
Name:ZMAT1
Synonyms:KIAA1789
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000166432.14
HGNCiHGNC:29377 ZMAT1
MIMi301007 gene
neXtProtiNX_Q5H9K5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880461

Polymorphism and mutation databases

DMDMi74762181

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113481 – 638Zinc finger matrin-type protein 1Add BLAST638

Proteomic databases

MaxQBiQ5H9K5
PaxDbiQ5H9K5
PeptideAtlasiQ5H9K5
PRIDEiQ5H9K5

PTM databases

iPTMnetiQ5H9K5
PhosphoSitePlusiQ5H9K5

Expressioni

Gene expression databases

BgeeiENSG00000166432
CleanExiHS_ZMAT1
GenevisibleiQ5H9K5 HS

Organism-specific databases

HPAiHPA012827

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124094, 8 interactors
IntActiQ5H9K5, 5 interactors
MINTiQ5H9K5
STRINGi9606.ENSP00000361868

Structurei

3D structure databases

ProteinModelPortaliQ5H9K5
SMRiQ5H9K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri56 – 86Matrin-type 1Add BLAST31
Zinc fingeri121 – 151Matrin-type 2Add BLAST31
Zinc fingeri172 – 206Matrin-type 3Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHK5 Eukaryota
ENOG410Y3E0 LUCA
HOGENOMiHOG000113259
HOVERGENiHBG099654
InParanoidiQ5H9K5
OrthoDBiEOG091G09ZX
PhylomeDBiQ5H9K5
TreeFamiTF337202

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SM00451 ZnF_U1, 3 hits
SUPFAMiSSF57667 SSF57667, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5H9K5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESCSVTRLE CSGAISAHCS LHLPGSSDSP ASASQIAGTT DAIWNEQEKA
60 70 80 90 100
ELFTDKFCQV CGVMLQFESQ RISHYEGEKH AQNVSFYFQM HGEQNEVPGK
110 120 130 140 150
KMKMHVENFQ VHRYEGVDKN KFCDLCNMMF SSPLIAQSHY VGKVHAKKLK
160 170 180 190 200
QLMEEHDQAS PSGFQPEMAF SMRTYVCHIC SIAFTSLDMF RSHMQGSEHQ
210 220 230 240 250
IKESIVINLV KNSRKTQDSY QNECADYINV QKARGLEAKT CFRKMEESSL
260 270 280 290 300
ETRRYREVVD SRPRHRMFEQ RLPFETFRTY AAPYNISQAM EKQLPHSKKT
310 320 330 340 350
YDSFQDELED YIKVQKARGL DPKTCFRKMR ENSVDTHGYR EMVDSGPRSR
360 370 380 390 400
MCEQRFSHEA SQTYQRPYHI SPVESQLPQW LPTHSKRTYD SFQDELEDYI
410 420 430 440 450
KVQKARGLEP KTCFRKIGDS SVETHRNREM VDVRPRHRML EQKLPCETFQ
460 470 480 490 500
TYSGPYSISQ VVENQLPHCL PAHDSKQRLD SISYCQLTRD CFPEKPVPLS
510 520 530 540 550
LNQQENNSGS YSVESEVYKH LSSENNTADH QAGHKQKHQK RKRHLEEGKE
560 570 580 590 600
RPEKEQSKHK RKKSYEDTDL DKDKSIRQRK REEDRVKVSS GKLKHRKKKK
610 620 630
SHDVPSEKEE RKHRKEKKKS VEERTEEEML WDESILGF
Length:638
Mass (Da):74,755
Last modified:February 15, 2005 - v1
Checksum:iD35B4FC2D112A87F
GO
Isoform 2 (identifier: Q5H9K5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:467
Mass (Da):55,545
Checksum:i1E29A73FCA9AED95
GO

Sequence cautioni

The sequence BAB47418 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053766214R → K. Corresponds to variant dbSNP:rs17282855Ensembl.1
Natural variantiVAR_062159536Q → R2 PublicationsCorresponds to variant dbSNP:rs5944882Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0295331 – 171Missing in isoform 2. 1 PublicationAdd BLAST171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058692 mRNA Translation: BAB47418.1 Different initiation.
Z68868 Genomic DNA No translation available.
Z69304 Genomic DNA No translation available.
AL831883 mRNA Translation: CAD38564.1
CCDSiCCDS35348.1 [Q5H9K5-1]
RefSeqiNP_001269329.1, NM_001282400.1
NP_001269330.1, NM_001282401.1
XP_006724774.1, XM_006724711.3
XP_016885393.1, XM_017029904.1
UniGeneiHs.496512

Genome annotation databases

EnsembliENST00000372782; ENSP00000361868; ENSG00000166432
ENST00000540921; ENSP00000437529; ENSG00000166432
GeneIDi84460
KEGGihsa:84460
UCSCiuc011mrl.3 human [Q5H9K5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZMAT1_HUMAN
AccessioniPrimary (citable) accession number: Q5H9K5
Secondary accession number(s): Q8NDS3, Q96JN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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