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Protein

Protein BEX5

Gene

BEX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX5
Alternative name(s):
Brain-expressed X-linked protein 5
NGFRAP1-like protein 1
Nerve growth factor receptor-associated protein 2
Gene namesi
Name:BEX5
Synonyms:NADE2, NGFRAP1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:27990. BEX5.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377554.

Polymorphism and mutation databases

BioMutaiBEX5.
DMDMi74755456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111Protein BEX5PRO_0000229788Add
BLAST

Post-translational modificationi

Ubiquitinated (Probable). Degraded by the proteasome.Curated

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ5H9J7.
PRIDEiQ5H9J7.

Expressioni

Gene expression databases

BgeeiQ5H9J7.
CleanExiHS_BEX5.
GenevisibleiQ5H9J7. HS.

Organism-specific databases

HPAiHPA059058.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EMILIN1Q9Y6C23EBI-10243741,EBI-744586
GOLGA8GQ08AF83EBI-10243741,EBI-10181260
MAGEA8P433614EBI-10243741,EBI-10182930

Protein-protein interaction databases

BioGridi131069. 4 interactions.
IntActiQ5H9J7. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5H9J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiNOG133237.
GeneTreeiENSGT00740000115473.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ5H9J7.
OMAiGEDVPNR.
OrthoDBiEOG7ZSHWF.
PhylomeDBiQ5H9J7.
TreeFamiTF337909.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5H9J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENVPKENKV VEKAPVQNEA PALGGGEYQE PGGNVKGVWA PPAPGFGEDV
60 70 80 90 100
PNRLVDNIDM IDGDGDDMER FMEEMRELRR KIRELQLRYS LRILIGDPPH
110
HDHHDEFCLM P
Length:111
Mass (Da):12,602
Last modified:February 15, 2005 - v1
Checksum:i1FCB30E1BAA20725
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271E → G in AAH92450 (PubMed:15489334).Curated
Sequence conflicti42 – 421P → H in AAH42818 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY833564 mRNA. Translation: AAX40682.1.
Z70719 Genomic DNA. Translation: CAI42011.1.
BC042818 mRNA. Translation: AAH42818.1.
BC092450 mRNA. Translation: AAH92450.1.
BC106955 mRNA. Translation: AAI06956.1.
CCDSiCCDS35350.1.
RefSeqiNP_001012996.1. NM_001012978.2.
NP_001153032.1. NM_001159560.1.
UniGeneiHs.47209.

Genome annotation databases

EnsembliENST00000333643; ENSP00000328030; ENSG00000184515.
ENST00000543160; ENSP00000446054; ENSG00000184515.
GeneIDi340542.
KEGGihsa:340542.
UCSCiuc004eir.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY833564 mRNA. Translation: AAX40682.1.
Z70719 Genomic DNA. Translation: CAI42011.1.
BC042818 mRNA. Translation: AAH42818.1.
BC092450 mRNA. Translation: AAH92450.1.
BC106955 mRNA. Translation: AAI06956.1.
CCDSiCCDS35350.1.
RefSeqiNP_001012996.1. NM_001012978.2.
NP_001153032.1. NM_001159560.1.
UniGeneiHs.47209.

3D structure databases

ProteinModelPortaliQ5H9J7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131069. 4 interactions.
IntActiQ5H9J7. 4 interactions.

Polymorphism and mutation databases

BioMutaiBEX5.
DMDMi74755456.

Proteomic databases

PaxDbiQ5H9J7.
PRIDEiQ5H9J7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333643; ENSP00000328030; ENSG00000184515.
ENST00000543160; ENSP00000446054; ENSG00000184515.
GeneIDi340542.
KEGGihsa:340542.
UCSCiuc004eir.3. human.

Organism-specific databases

CTDi340542.
GeneCardsiGC0XM101408.
HGNCiHGNC:27990. BEX5.
HPAiHPA059058.
MIMi300693. gene.
neXtProtiNX_Q5H9J7.
PharmGKBiPA162377554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG133237.
GeneTreeiENSGT00740000115473.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ5H9J7.
OMAiGEDVPNR.
OrthoDBiEOG7ZSHWF.
PhylomeDBiQ5H9J7.
TreeFamiTF337909.

Miscellaneous databases

GenomeRNAii340542.
NextBioi97912.
PROiQ5H9J7.
SOURCEiSearch...

Gene expression databases

BgeeiQ5H9J7.
CleanExiHS_BEX5.
GenevisibleiQ5H9J7. HS.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the Bex gene family in humans, mice, and rats."
    Alvarez E., Zhou W., Witta S.E., Freed C.R.
    Gene 357:18-28(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEGRADATION BY THE PROTEASOME.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiBEX5_HUMAN
AccessioniPrimary (citable) accession number: Q5H9J7
Secondary accession number(s): Q569J0, Q56A74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 15, 2005
Last modified: July 22, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The mouse orthologous protein seems not to exist. Koo et al (PubMed:15861462) have described a sequence that they named Bex5, but it probably represents a pseudogene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.