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Q5H9J7

- BEX5_HUMAN

UniProt

Q5H9J7 - BEX5_HUMAN

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Protein

Protein BEX5

Gene

BEX5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX5
Alternative name(s):
Brain-expressed X-linked protein 5
NGFRAP1-like protein 1
Nerve growth factor receptor-associated protein 2
Gene namesi
Name:BEX5
Synonyms:NADE2, NGFRAP1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:27990. BEX5.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111Protein BEX5PRO_0000229788Add
BLAST

Post-translational modificationi

Ubiquitinated (Probable). Degraded by the proteasome.Curated

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ5H9J7.
PRIDEiQ5H9J7.

Expressioni

Gene expression databases

BgeeiQ5H9J7.
CleanExiHS_BEX5.
GenevestigatoriQ5H9J7.

Organism-specific databases

HPAiHPA059058.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328030.

Structurei

3D structure databases

ProteinModelPortaliQ5H9J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiNOG133237.
GeneTreeiENSGT00740000115473.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ5H9J7.
OMAiIDMIDGD.
OrthoDBiEOG7ZSHWF.
PhylomeDBiQ5H9J7.
TreeFamiTF337909.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5H9J7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENVPKENKV VEKAPVQNEA PALGGGEYQE PGGNVKGVWA PPAPGFGEDV
60 70 80 90 100
PNRLVDNIDM IDGDGDDMER FMEEMRELRR KIRELQLRYS LRILIGDPPH
110
HDHHDEFCLM P
Length:111
Mass (Da):12,602
Last modified:February 15, 2005 - v1
Checksum:i1FCB30E1BAA20725
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271E → G in AAH92450. (PubMed:15489334)Curated
Sequence conflicti42 – 421P → H in AAH42818. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY833564 mRNA. Translation: AAX40682.1.
Z70719 Genomic DNA. Translation: CAI42011.1.
BC042818 mRNA. Translation: AAH42818.1.
BC092450 mRNA. Translation: AAH92450.1.
BC106955 mRNA. Translation: AAI06956.1.
CCDSiCCDS35350.1.
RefSeqiNP_001012996.1. NM_001012978.2.
NP_001153032.1. NM_001159560.1.
UniGeneiHs.47209.

Genome annotation databases

EnsembliENST00000333643; ENSP00000328030; ENSG00000184515.
ENST00000543160; ENSP00000446054; ENSG00000184515.
GeneIDi340542.
KEGGihsa:340542.
UCSCiuc004eir.3. human.

Polymorphism databases

DMDMi74755456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY833564 mRNA. Translation: AAX40682.1 .
Z70719 Genomic DNA. Translation: CAI42011.1 .
BC042818 mRNA. Translation: AAH42818.1 .
BC092450 mRNA. Translation: AAH92450.1 .
BC106955 mRNA. Translation: AAI06956.1 .
CCDSi CCDS35350.1.
RefSeqi NP_001012996.1. NM_001012978.2.
NP_001153032.1. NM_001159560.1.
UniGenei Hs.47209.

3D structure databases

ProteinModelPortali Q5H9J7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000328030.

Polymorphism databases

DMDMi 74755456.

Proteomic databases

PaxDbi Q5H9J7.
PRIDEi Q5H9J7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333643 ; ENSP00000328030 ; ENSG00000184515 .
ENST00000543160 ; ENSP00000446054 ; ENSG00000184515 .
GeneIDi 340542.
KEGGi hsa:340542.
UCSCi uc004eir.3. human.

Organism-specific databases

CTDi 340542.
GeneCardsi GC0XM101408.
HGNCi HGNC:27990. BEX5.
HPAi HPA059058.
MIMi 300693. gene.
neXtProti NX_Q5H9J7.
PharmGKBi PA162377554.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG133237.
GeneTreei ENSGT00740000115473.
HOGENOMi HOG000236300.
HOVERGENi HBG080240.
InParanoidi Q5H9J7.
OMAi IDMIDGD.
OrthoDBi EOG7ZSHWF.
PhylomeDBi Q5H9J7.
TreeFami TF337909.

Miscellaneous databases

GenomeRNAii 340542.
NextBioi 97912.
PROi Q5H9J7.
SOURCEi Search...

Gene expression databases

Bgeei Q5H9J7.
CleanExi HS_BEX5.
Genevestigatori Q5H9J7.

Family and domain databases

InterProi IPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view ]
Pfami PF04538. BEX. 1 hit.
[Graphical view ]
PIRSFi PIRSF008633. BEX. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the Bex gene family in humans, mice, and rats."
    Alvarez E., Zhou W., Witta S.E., Freed C.R.
    Gene 357:18-28(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEGRADATION BY THE PROTEASOME.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiBEX5_HUMAN
AccessioniPrimary (citable) accession number: Q5H9J7
Secondary accession number(s): Q569J0, Q56A74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The mouse orthologous protein seems not to exist. Koo et al (PubMed:15861462) have described a sequence that they named Bex5, but it probably represents a pseudogene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3