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Q5H9J7 (BEX5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein BEX5
Alternative name(s):
Brain-expressed X-linked protein 5
NGFRAP1-like protein 1
Nerve growth factor receptor-associated protein 2
Gene names
Name:BEX5
Synonyms:NADE2, NGFRAP1L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length111 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm Ref.1.

Post-translational modification

Ubiquitinated Probable. Degraded by the proteasome. Ref.1

Miscellaneous

The mouse orthologous protein seems not to exist. Koo et al (PubMed:15861462) have described a sequence that they named Bex5, but it probably represents a pseudogene.

Sequence similarities

Belongs to the BEX family.

Ontologies

Keywords
   Cellular componentCytoplasm
   PTMUbl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 111111Protein BEX5
PRO_0000229788

Experimental info

Sequence conflict271E → G in AAH92450. Ref.3
Sequence conflict421P → H in AAH42818. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q5H9J7 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 1FCB30E1BAA20725

FASTA11112,602
        10         20         30         40         50         60 
MENVPKENKV VEKAPVQNEA PALGGGEYQE PGGNVKGVWA PPAPGFGEDV PNRLVDNIDM 

        70         80         90        100        110 
IDGDGDDMER FMEEMRELRR KIRELQLRYS LRILIGDPPH HDHHDEFCLM P 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the Bex gene family in humans, mice, and rats."
Alvarez E., Zhou W., Witta S.E., Freed C.R.
Gene 357:18-28(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEGRADATION BY THE PROTEASOME.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY833564 mRNA. Translation: AAX40682.1.
Z70719 Genomic DNA. Translation: CAI42011.1.
BC042818 mRNA. Translation: AAH42818.1.
BC092450 mRNA. Translation: AAH92450.1.
BC106955 mRNA. Translation: AAI06956.1.
RefSeqNP_001012996.1. NM_001012978.2.
NP_001153032.1. NM_001159560.1.
UniGeneHs.47209.

3D structure databases

ProteinModelPortalQ5H9J7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000328030.

Polymorphism databases

DMDM74755456.

Proteomic databases

PaxDbQ5H9J7.
PRIDEQ5H9J7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333643; ENSP00000328030; ENSG00000184515.
ENST00000543160; ENSP00000446054; ENSG00000184515.
ENST00000594094; ENSP00000469862; ENSG00000269503.
ENST00000602137; ENSP00000469622; ENSG00000269503.
GeneID340542.
KEGGhsa:340542.
UCSCuc004eir.3. human.

Organism-specific databases

CTD340542.
GeneCardsGC0XM101408.
HGNCHGNC:27990. BEX5.
HPAHPA059058.
MIM300693. gene.
neXtProtNX_Q5H9J7.
PharmGKBPA162377554.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG133237.
HOGENOMHOG000236300.
HOVERGENHBG080240.
InParanoidQ5H9J7.
OMAERFMEEM.
OrthoDBEOG7ZSHWF.
PhylomeDBQ5H9J7.
TreeFamTF337909.

Gene expression databases

BgeeQ5H9J7.
CleanExHS_BEX5.
GenevestigatorQ5H9J7.

Family and domain databases

InterProIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamPF04538. BEX. 1 hit.
[Graphical view]
PIRSFPIRSF008633. BEX. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi340542.
NextBio97912.
PROQ5H9J7.
SOURCESearch...

Entry information

Entry nameBEX5_HUMAN
AccessionPrimary (citable) accession number: Q5H9J7
Secondary accession number(s): Q569J0, Q56A74
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM