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Protein

Protein BEX5

Gene

BEX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

The mouse orthologous protein seems not to exist. Koo et al (PubMed:15861462) have described a sequence that they named Bex5, but it probably represents a pseudogene.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX5
Alternative name(s):
Brain-expressed X-linked protein 5
NGFRAP1-like protein 1
Nerve growth factor receptor-associated protein 2
Gene namesi
Name:BEX5
Synonyms:NADE2, NGFRAP1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000184515.10
HGNCiHGNC:27990 BEX5
MIMi300693 gene
neXtProtiNX_Q5H9J7

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184515
PharmGKBiPA162377554

Polymorphism and mutation databases

BioMutaiBEX5
DMDMi74755456

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297881 – 111Protein BEX5Add BLAST111

Post-translational modificationi

Ubiquitinated (Probable). Degraded by the proteasome.Curated

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ5H9J7
PeptideAtlasiQ5H9J7
PRIDEiQ5H9J7

Expressioni

Gene expression databases

BgeeiENSG00000184515
CleanExiHS_BEX5
GenevisibleiQ5H9J7 HS

Organism-specific databases

HPAiHPA059058

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131069, 5 interactors
IntActiQ5H9J7, 14 interactors
STRINGi9606.ENSP00000328030

Structurei

3D structure databases

ProteinModelPortaliQ5H9J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410IYQR Eukaryota
ENOG41116UZ LUCA
GeneTreeiENSGT00810000125492
HOGENOMiHOG000236300
HOVERGENiHBG080240
InParanoidiQ5H9J7
OMAiGEDVPNR
OrthoDBiEOG091G0XPB
PhylomeDBiQ5H9J7
TreeFamiTF337909

Family and domain databases

InterProiView protein in InterPro
IPR007623 BEX
IPR021156 TF_A-like/BEX
PfamiView protein in Pfam
PF04538 BEX, 1 hit
PIRSFiPIRSF008633 BEX, 1 hit

Sequencei

Sequence statusi: Complete.

Q5H9J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENVPKENKV VEKAPVQNEA PALGGGEYQE PGGNVKGVWA PPAPGFGEDV
60 70 80 90 100
PNRLVDNIDM IDGDGDDMER FMEEMRELRR KIRELQLRYS LRILIGDPPH
110
HDHHDEFCLM P
Length:111
Mass (Da):12,602
Last modified:February 15, 2005 - v1
Checksum:i1FCB30E1BAA20725
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27E → G in AAH92450 (PubMed:15489334).Curated1
Sequence conflicti42P → H in AAH42818 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY833564 mRNA Translation: AAX40682.1
Z70719 Genomic DNA No translation available.
BC042818 mRNA Translation: AAH42818.1
BC092450 mRNA Translation: AAH92450.1
BC106955 mRNA Translation: AAI06956.1
CCDSiCCDS35350.1
RefSeqiNP_001012996.1, NM_001012978.2
NP_001153032.1, NM_001159560.1
UniGeneiHs.47209

Genome annotation databases

EnsembliENST00000333643; ENSP00000328030; ENSG00000184515
ENST00000543160; ENSP00000446054; ENSG00000184515
GeneIDi340542
KEGGihsa:340542
UCSCiuc004eir.4 human

Similar proteinsi

Entry informationi

Entry nameiBEX5_HUMAN
AccessioniPrimary (citable) accession number: Q5H9J7
Secondary accession number(s): Q569J0, Q56A74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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