Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5H9J7

- BEX5_HUMAN

UniProt

Q5H9J7 - BEX5_HUMAN

Protein

Protein BEX5

Gene

BEX5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein BEX5
    Alternative name(s):
    Brain-expressed X-linked protein 5
    NGFRAP1-like protein 1
    Nerve growth factor receptor-associated protein 2
    Gene namesi
    Name:BEX5
    Synonyms:NADE2, NGFRAP1L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:27990. BEX5.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162377554.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 111111Protein BEX5PRO_0000229788Add
    BLAST

    Post-translational modificationi

    Ubiquitinated Probable. Degraded by the proteasome.Curated

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ5H9J7.
    PRIDEiQ5H9J7.

    Expressioni

    Gene expression databases

    BgeeiQ5H9J7.
    CleanExiHS_BEX5.
    GenevestigatoriQ5H9J7.

    Organism-specific databases

    HPAiHPA059058.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000328030.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5H9J7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BEX family.Curated

    Phylogenomic databases

    eggNOGiNOG133237.
    HOGENOMiHOG000236300.
    HOVERGENiHBG080240.
    InParanoidiQ5H9J7.
    OMAiIDMIDGD.
    OrthoDBiEOG7ZSHWF.
    PhylomeDBiQ5H9J7.
    TreeFamiTF337909.

    Family and domain databases

    InterProiIPR007623. BEX.
    IPR021156. TF_A-like/BEX-like.
    [Graphical view]
    PfamiPF04538. BEX. 1 hit.
    [Graphical view]
    PIRSFiPIRSF008633. BEX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5H9J7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENVPKENKV VEKAPVQNEA PALGGGEYQE PGGNVKGVWA PPAPGFGEDV    50
    PNRLVDNIDM IDGDGDDMER FMEEMRELRR KIRELQLRYS LRILIGDPPH 100
    HDHHDEFCLM P 111
    Length:111
    Mass (Da):12,602
    Last modified:February 15, 2005 - v1
    Checksum:i1FCB30E1BAA20725
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271E → G in AAH92450. (PubMed:15489334)Curated
    Sequence conflicti42 – 421P → H in AAH42818. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY833564 mRNA. Translation: AAX40682.1.
    Z70719 Genomic DNA. Translation: CAI42011.1.
    BC042818 mRNA. Translation: AAH42818.1.
    BC092450 mRNA. Translation: AAH92450.1.
    BC106955 mRNA. Translation: AAI06956.1.
    CCDSiCCDS35350.1.
    RefSeqiNP_001012996.1. NM_001012978.2.
    NP_001153032.1. NM_001159560.1.
    UniGeneiHs.47209.

    Genome annotation databases

    EnsembliENST00000333643; ENSP00000328030; ENSG00000184515.
    ENST00000543160; ENSP00000446054; ENSG00000184515.
    GeneIDi340542.
    KEGGihsa:340542.
    UCSCiuc004eir.3. human.

    Polymorphism databases

    DMDMi74755456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY833564 mRNA. Translation: AAX40682.1 .
    Z70719 Genomic DNA. Translation: CAI42011.1 .
    BC042818 mRNA. Translation: AAH42818.1 .
    BC092450 mRNA. Translation: AAH92450.1 .
    BC106955 mRNA. Translation: AAI06956.1 .
    CCDSi CCDS35350.1.
    RefSeqi NP_001012996.1. NM_001012978.2.
    NP_001153032.1. NM_001159560.1.
    UniGenei Hs.47209.

    3D structure databases

    ProteinModelPortali Q5H9J7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000328030.

    Polymorphism databases

    DMDMi 74755456.

    Proteomic databases

    PaxDbi Q5H9J7.
    PRIDEi Q5H9J7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333643 ; ENSP00000328030 ; ENSG00000184515 .
    ENST00000543160 ; ENSP00000446054 ; ENSG00000184515 .
    GeneIDi 340542.
    KEGGi hsa:340542.
    UCSCi uc004eir.3. human.

    Organism-specific databases

    CTDi 340542.
    GeneCardsi GC0XM101408.
    HGNCi HGNC:27990. BEX5.
    HPAi HPA059058.
    MIMi 300693. gene.
    neXtProti NX_Q5H9J7.
    PharmGKBi PA162377554.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG133237.
    HOGENOMi HOG000236300.
    HOVERGENi HBG080240.
    InParanoidi Q5H9J7.
    OMAi IDMIDGD.
    OrthoDBi EOG7ZSHWF.
    PhylomeDBi Q5H9J7.
    TreeFami TF337909.

    Miscellaneous databases

    GenomeRNAii 340542.
    NextBioi 97912.
    PROi Q5H9J7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5H9J7.
    CleanExi HS_BEX5.
    Genevestigatori Q5H9J7.

    Family and domain databases

    InterProi IPR007623. BEX.
    IPR021156. TF_A-like/BEX-like.
    [Graphical view ]
    Pfami PF04538. BEX. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF008633. BEX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the Bex gene family in humans, mice, and rats."
      Alvarez E., Zhou W., Witta S.E., Freed C.R.
      Gene 357:18-28(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEGRADATION BY THE PROTEASOME.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiBEX5_HUMAN
    AccessioniPrimary (citable) accession number: Q5H9J7
    Secondary accession number(s): Q569J0, Q56A74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The mouse orthologous protein seems not to exist. Koo et al (PubMed:15861462) have described a sequence that they named Bex5, but it probably represents a pseudogene.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3