Q5H9J7 (BEX5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein BEX5

Alternative name(s):
Brain-expressed X-linked protein 5
NGFRAP1-like protein 1
Nerve growth factor receptor-associated protein 2

Gene names

Name:	BEX5
Synonyms:	NADE2, NGFRAP1L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm Ref.1.
Post-translational modification	Ubiquitinated Probable. Degraded by the proteasome. Ref.1
Miscellaneous	The mouse orthologous protein seems not to exist. Koo et al (PubMed:15861462) have described a sequence that they named Bex5, but it probably represents a pseudogene.
Sequence similarities	Belongs to the BEX family.

Ontologies

Keywords
Cellular component	Cytoplasm
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 111	111	Protein BEX5		PRO_0000229788
Experimental info
	Sequence conflict	27	1	E → G in AAH92450. Ref.3
	Sequence conflict	42	1	P → H in AAH42818. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q5H9J7 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 1FCB30E1BAA20725	FASTA	111	12,602
	10 20 30 40 50 60 MENVPKENKV VEKAPVQNEA PALGGGEYQE PGGNVKGVWA PPAPGFGEDV PNRLVDNIDM 70 80 90 100 110 IDGDGDDMER FMEEMRELRR KIRELQLRYS LRILIGDPPH HDHHDEFCLM P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the Bex gene family in humans, mice, and rats." Alvarez E., Zhou W., Witta S.E., Freed C.R. Gene 357:18-28(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEGRADATION BY THE PROTEASOME.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY833564 mRNA. Translation: AAX40682.1. Z70719 Genomic DNA. Translation: CAI42011.1. BC042818 mRNA. Translation: AAH42818.1. BC092450 mRNA. Translation: AAH92450.1. BC106955 mRNA. Translation: AAI06956.1.
IPI	IPI00257933.
RefSeq	NP_001012996.1. NM_001012978.2. NP_001153032.1. NM_001159560.1.
UniGene	Hs.47209.
3D structure databases
ProteinModelPortal	Q5H9J7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000328030.
Polymorphism databases
DMDM	74755456.
Proteomic databases
PaxDb	Q5H9J7.
PRIDE	Q5H9J7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333643; ENSP00000328030; ENSG00000184515. ENST00000543160; ENSP00000446054; ENSG00000184515. ENST00000594094; ENSP00000469862; ENSG00000269503. ENST00000602137; ENSP00000469622; ENSG00000269503.
GeneID	340542.
KEGG	hsa:340542.
UCSC	uc004eir.3. human.
Organism-specific databases
CTD	340542.
GeneCards	GC0XM101408.
HGNC	HGNC:27990. BEX5.
MIM	300693. gene.
neXtProt	NX_Q5H9J7.
PharmGKB	PA162377554.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG133237.
HOGENOM	HOG000236300.
HOVERGEN	HBG080240.
InParanoid	Q5H9J7.
OMA	ERFMEEM.
OrthoDB	EOG4K9BDS.
Gene expression databases
Bgee	Q5H9J7.
CleanEx	HS_BEX5.
Genevestigator	Q5H9J7.
GermOnline	ENSG00000184515. Homo sapiens.
Family and domain databases
InterPro	IPR007623. BEX. IPR021156. TF_A-like/BEX-like. [Graphical view]
Pfam	PF04538. BEX. 1 hit. [Graphical view]
PIRSF	PIRSF008633. BEX. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	340542.
NextBio	97912.
SOURCE	Search...

Entry information

Entry name

BEX5_HUMAN

Accession

Primary (citable) accession number: Q5H9J7
Secondary accession number(s): Q569J0, Q56A74

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.