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Q5H9I0

- TFDP3_HUMAN

UniProt

Q5H9I0 - TFDP3_HUMAN

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Protein
Transcription factor Dp family member 3
Gene
TFDP3, DP4, HCA661
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G1 to S phase.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei121 – 1211Critical for repression of E2F activity
Sitei130 – 1301Critical for repression of E2F activity
Sitei131 – 1311Critical for repression of E2F activity
Sitei140 – 1401Critical for repression of E2F activity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi108 – 19083 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: UniProtKB
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Dp family member 3
Alternative name(s):
Cancer/testis antigen 30
Short name:
CT30
Hepatocellular carcinoma-associated antigen 661
Gene namesi
Name:TFDP3
Synonyms:DP4, HCA661
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:24603. TFDP3.

Subcellular locationi

Nucleus. Cytoplasm
Note: Translocates to the nucleus on heterodimerization with E2F family members.2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB-SubCell
  3. transcription factor complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi112 – 1121C → R: No effect on down-regulation of E2F transcriptional activity; when associated with or without R-161 or with V-164.
Mutagenesisi121 – 1211T → K: Restores enhanced E2F-mediated transcriptional activity; when associated with Y-130; N-131 and E-145. 1 Publication
Mutagenesisi130 – 1301C → Y: Restores enhanced E2F-mediated transcriptional activity; when associated with K-121; N-131 and E-145. 1 Publication
Mutagenesisi131 – 1311Q → N: Restores enhanced E2F-mediated transcriptional activity; when associated with K-121; Y-130 and E-145. 1 Publication
Mutagenesisi140 – 1401K → E: Restores enhanced E2F-mediated transcriptional activity; when associated with K-121; Y-130 and N-131. 1 Publication
Mutagenesisi161 – 1611K → R: No effect on down-regulation of E2F transcriptional activity; when associated with or without R-112.
Mutagenesisi164 – 1641T → V: No effect on down-regulation of E2F transcriptional activity; when associated R-112.

Organism-specific databases

PharmGKBiPA134898258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Transcription factor Dp family member 3
PRO_0000305940Add
BLAST

Proteomic databases

PaxDbiQ5H9I0.
PRIDEiQ5H9I0.

PTM databases

PhosphoSiteiQ5H9I0.

Expressioni

Tissue specificityi

Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines.2 Publications

Inductioni

In response to DNA damage.1 Publication

Gene expression databases

BgeeiQ5H9I0.
CleanExiHS_TFDP3.
GenevestigatoriQ5H9I0.

Interactioni

Subunit structurei

Heterodimer: with E2F family members. TFDP3/E2F heterodimers do not bind DNA and repress E2F-dependent transcriptional activity.2 Publications

Protein-protein interaction databases

BioGridi119423. 2 interactions.
IntActiQ5H9I0. 1 interaction.
STRINGi9606.ENSP00000385461.

Structurei

3D structure databases

ProteinModelPortaliQ5H9I0.
SMRiQ5H9I0. Positions 108-189, 194-341.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni175 – 306132Involved in negatively regulating E2F activity
Add
BLAST
Regioni209 – 24133DCB1 By similarity
Add
BLAST
Regioni254 – 31057DCB2 By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi156 – 19035DEF box By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi386 – 40217Asp/Glu-rich (acidic; NCB domain)
Add
BLAST

Domaini

The potential DNA-binding domain differs in sequence from that of other DP family members and can not bind DNA.

Sequence similaritiesi

Belongs to the E2F/DP family.

Phylogenomic databases

eggNOGiNOG282881.
HOGENOMiHOG000030696.
HOVERGENiHBG009894.
InParanoidiQ5H9I0.
KOiK09393.
OMAiNIKRRTY.
OrthoDBiEOG7C2R27.
PhylomeDBiQ5H9I0.
TreeFamiTF314396.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003316. E2F_TDP.
IPR028315. TFDP3.
IPR014889. Transc_factor_DP_C.
IPR015648. Transcrpt_fac_DP.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12548. PTHR12548. 1 hit.
PTHR12548:SF13. PTHR12548:SF13. 1 hit.
PfamiPF08781. DP. 1 hit.
PF02319. E2F_TDP. 1 hit.
[Graphical view]
PIRSFiPIRSF009404. Transcription_factor_DP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5H9I0-1 [UniParc]FASTAAdd to Basket

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MAKYVSLTEA NEELKVLMDE NQTSRPVAVH TSTVNPLGKQ LLPKTFGQSS    50
VNIDQQVVIG MPQRPAASNI PVVGSPNPPS THFASQNQHS YSSPPWAGQH 100
NRKGEKNGMG LCRLSMKVWE TVQRKGTTSC QEVVGELVAK FRAASNHASP 150
NESAYDVKNI KRRTYDALNV LMAMNIISRE KKKIKWIGLT TNSAQNCQNL 200
RVERQKRLER IKQKQSELQQ LILQQIAFKN LVLRNQYVEE QVSQRPLPNS 250
VIHVPFIIIS SSKKTVINCS ISDDKSEYLF KFNSSFEIHD DTEVLMWMGM 300
TFGLESGSCS AEDLKMARNL VPKALEPYVT EMAQGTFGGV FTTAGSRSNG 350
TWLSASDLTN IAIGMLATSS GGSQYSGSRV ETPAVEEEEE EDNNDDDLSE 400
NDEDD 405
Length:405
Mass (Da):44,967
Last modified:February 15, 2005 - v1
Checksum:iAE6F5709FE7E4C03
GO

Sequence cautioni

The sequence AAF37562.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF219119 mRNA. Translation: AAF37562.2. Different initiation.
Z77249 Genomic DNA. Translation: CAI42694.1.
CH471107 Genomic DNA. Translation: EAX11773.1.
CCDSiCCDS14636.2.
RefSeqiNP_057605.3. NM_016521.2.
UniGeneiHs.142908.

Genome annotation databases

EnsembliENST00000310125; ENSP00000385461; ENSG00000183434.
GeneIDi51270.
KEGGihsa:51270.
UCSCiuc004exb.1. human.

Polymorphism databases

DMDMi74762180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF219119 mRNA. Translation: AAF37562.2 . Different initiation.
Z77249 Genomic DNA. Translation: CAI42694.1 .
CH471107 Genomic DNA. Translation: EAX11773.1 .
CCDSi CCDS14636.2.
RefSeqi NP_057605.3. NM_016521.2.
UniGenei Hs.142908.

3D structure databases

ProteinModelPortali Q5H9I0.
SMRi Q5H9I0. Positions 108-189, 194-341.
ModBasei Search...

Protein-protein interaction databases

BioGridi 119423. 2 interactions.
IntActi Q5H9I0. 1 interaction.
STRINGi 9606.ENSP00000385461.

PTM databases

PhosphoSitei Q5H9I0.

Polymorphism databases

DMDMi 74762180.

Proteomic databases

PaxDbi Q5H9I0.
PRIDEi Q5H9I0.

Protocols and materials databases

DNASUi 51270.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310125 ; ENSP00000385461 ; ENSG00000183434 .
GeneIDi 51270.
KEGGi hsa:51270.
UCSCi uc004exb.1. human.

Organism-specific databases

CTDi 51270.
GeneCardsi GC0XM132350.
HGNCi HGNC:24603. TFDP3.
MIMi 300772. gene.
neXtProti NX_Q5H9I0.
PharmGKBi PA134898258.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282881.
HOGENOMi HOG000030696.
HOVERGENi HBG009894.
InParanoidi Q5H9I0.
KOi K09393.
OMAi NIKRRTY.
OrthoDBi EOG7C2R27.
PhylomeDBi Q5H9I0.
TreeFami TF314396.

Miscellaneous databases

GenomeRNAii 51270.
NextBioi 54467.
PROi Q5H9I0.
SOURCEi Search...

Gene expression databases

Bgeei Q5H9I0.
CleanExi HS_TFDP3.
Genevestigatori Q5H9I0.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR003316. E2F_TDP.
IPR028315. TFDP3.
IPR014889. Transc_factor_DP_C.
IPR015648. Transcrpt_fac_DP.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR12548. PTHR12548. 1 hit.
PTHR12548:SF13. PTHR12548:SF13. 1 hit.
Pfami PF08781. DP. 1 hit.
PF02319. E2F_TDP. 1 hit.
[Graphical view ]
PIRSFi PIRSF009404. Transcription_factor_DP. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."
    Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y., Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W., Chen W.-F.
    J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
    Tissue: Hepatoma.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F."
    Qiao H., Di Stefano L., Tian C., Li Y.Y., Yin Y.H., Qian X.P., Pang X.W., Li Y., McNutt M.A., Helin K., Zhang Y., Chen W.F.
    J. Biol. Chem. 282:454-466(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, MUTAGENESIS OF THR-121; CYS-130; GLN-131 AND LYS-140.
  6. "E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit."
    Ingram L., Munro S., Coutts A.S., La Thangue N.B.
    Cell Death Differ. 18:122-132(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INDUCTION.

Entry informationi

Entry nameiTFDP3_HUMAN
AccessioniPrimary (citable) accession number: Q5H9I0
Secondary accession number(s): Q6DK49, Q9NZ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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