Q5H9F3 (BCORL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BCL-6 corepressor-like protein 1
Short name=BCoR-L1
Short name=BCoR-like protein 1

Gene names

Name:

BCORL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1711 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Ref.5
Subunit structure	Interacts with CTBP1. Interacts with HDAC4, HDAC5 and HDAC7. Ref.5
Subcellular location	Nucleus Ref.5.
Tissue specificity	Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen. Ref.5
Sequence similarities	Belongs to the BCOR family. Contains 3 ANK repeats.
Sequence caution	The sequence BAC85922.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat
Molecular function	Chromatin regulator Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5H9F3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5H9F3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1230-1359: Missing.

Isoform 3 (identifier: Q5H9F3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1434-1434: A → AKGKGRWSQQ...LLQRAARLGY

Note: Contains a phosphoserine at position 1476.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1711	1711	BCL-6 corepressor-like protein 1		PRO_0000312268
Regions
	Repeat	1455 – 1484	30	ANK 1
	Repeat	1488 – 1517	30	ANK 2
	Repeat	1521 – 1549	29	ANK 3
	Motif	1328 – 1336	9	Nuclear localization signal Potential
	Compositional bias	198 – 649	452	Pro-rich
Amino acid modifications
	Modified residue	613	1	Phosphoserine Ref.6
	Modified residue	1033	1	Phosphoserine Ref.6
	Modified residue	1162	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1230 – 1359	130	Missing in isoform 2.		VSP_029778
	Alternative sequence	1434	1	A → AKGKGRWSQQKTRSPKSPTP VKPTEPCTPSKSRSASSEEA SESPTARQIPPEARRLIVNK NAGETLLQRAARLGY in isoform 3.		VSP_029779
	Natural variant	111	1	F → L. Ref.2 Corresponds to variant rs4830173 [ dbSNP | Ensembl ].		VAR_061020
	Natural variant	209	1	G → S. Corresponds to variant rs5932715 [ dbSNP | Ensembl ].		VAR_037467
	Natural variant	832	1	G → D in a breast cancer sample; somatic mutation. Ref.7		VAR_037468
Experimental info
	Mutagenesis	623 – 624	2	DL → AS: Strongly reduced repressor activity. Interferes with CTBP1 binding. Ref.5
	Sequence conflict	1564	1	V → A in BAC85922. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: DD78A00598703C53	FASTA	1,711	182,526
	10 20 30 40 50 60 MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GDCQHFGSQE FCVSSSFSKV 70 80 90 100 110 120 ELTAVGSGSN ARGADPDGSA TEKLGHKSED KPDDPQPKMD YAGNVAEAEG FLVPLSSPGD 130 140 150 160 170 180 GLKLPASDSA EASNSRADCS WTPLNTQMSK QVDCSPAGVK ALDSRQGVGE KNTFILATLG 190 200 210 220 230 240 TGVPVEGTLP LVTTNFSPLP APICPPAPGS ASVPHSVPDA FQVPLSVPAP VPHSGLVPVQ 250 260 270 280 290 300 VATSVPAPSP PLAPVPALAP APPSVPTLIS DSNPLSVSAS VLVPVPASAP PSGPVPLSAP 310 320 330 340 350 360 APAPLSVPVS APPLALIQAP VPPSAPTLVL APVPTPVLAP MPASTPPAAP APPSVPMPTP 370 380 390 400 410 420 TPSSGPPSTP TLIPAFAPTP VPAPTPAPIF TPAPTPMPAA TPAAIPTSAP IPASFSLSRV 430 440 450 460 470 480 CFPAAQAPAM QKVPLSFQPG TVLTPSQPLV YIPPPSCGQP LSVATLPTTL GVSSTLTLPV 490 500 510 520 530 540 LPSYLQDRCL PGVLASPELR SYPYAFSVAR PLTSDSKLVS LEVNRLPCTS PSGSTTTQPA 550 560 570 580 590 600 PDGVPGPLAD TSLVTASAKV LPTPQPLLPA PSGSSAPPHP AKMPSGTEQQ TEGTSVTFSP 610 620 630 640 650 660 LKSPPQLERE MASPPECSEM PLDLSSKSNR QKLPLPNQRK TPPMPVLTPV HTSSKALLST 670 680 690 700 710 720 VLSRSQRTTQ AAGGNVTSCL GSTSSPFVIF PEIVRNGDPS TWVKNSTALI STIPGTYVGV 730 740 750 760 770 780 ANPVPASLLL NKDPNLGLNR DPRHLPKQEP ISIIDQGEPK GTGATCGKKG SQAGAEGQPS 790 800 810 820 830 840 TVKRYTPARI APGLPGCQTK ELSLWKPTGP ANIYPRCSVN GKPTSTQVLP VGWSPYHQAS 850 860 870 880 890 900 LLSIGISSAG QLTPSQGAPI RPTSVVSEFS GVPSLSSSEA VHGLPEGQPR PGGSFVPEQD 910 920 930 940 950 960 PVTKNKTCRI AAKPYEEQVN PVLLTLSPQT GTLALSVQPS GGDIRMNQGP EESESHLCSD 970 980 990 1000 1010 1020 STPKMEGPQG ACGLKLAGDT KPKNQVLATY MSHELVLATP QNLPKMPELP LLPHDSHPKE 1030 1040 1050 1060 1070 1080 LILDVVPSSR RGSSTERPQL GSQVDLGRVK MEKVDGDVVF NLATCFRADG LPVAPQRGQA 1090 1100 1110 1120 1130 1140 EVRAKAGQAR VKQESVGVFA CKNKWQPDDV TESLPPKKMK CGKEKDSEEQ QLQPQAKAVV 1150 1160 1170 1180 1190 1200 RSSHRPKCRK LPSDPQESTK KSPRGASDSG KEHNGVRGKH KHRKPTKPES QSPGKRADSH 1210 1220 1230 1240 1250 1260 EEGSLEKKAK SSFRDFIPVV LSTRTRSQSG SICSSFAGMA DSDMGSQEVF PTEEEEEVTP 1270 1280 1290 1300 1310 1320 TPAKRRKVRK TQRDTQYRSH HAQDKSLLSQ GRRHLWRARE MPWRTEAARQ MWDTNEEEEE 1330 1340 1350 1360 1370 1380 EEEEGLLKRK KRRRQKSRKY QTGEYLTEQE DEQRRKGRAD LKARKQKTSS SQSLEHRLRN 1390 1400 1410 1420 1430 1440 RNLLLPNKVQ GISDSPNGFL PNNLEEPACL ENSEKPSGKR KCKTKHMATV SEEAKDVVLY 1450 1460 1470 1480 1490 1500 CLQKDSEDVN HRDNAGYTAL HEACSRGWTD ILNILLEHGA NVNCSAQDGT RPVHDAVVND 1510 1520 1530 1540 1550 1560 NLETIWLLLS YGADPTLATY SGQTAMKLAS SDTMKRFLSD HLSDLQGRAE GDPGVSWDFY 1570 1580 1590 1600 1610 1620 SSSVLEEKDG FACDLLHNPP GSSDQEGDDP MEEDDFMFEL SDKPLLPCYN LQVSVSRGPC 1630 1640 1650 1660 1670 1680 NWFLFSDVLK RLKLSSRIFQ ARFPHFEITT MPKAEFYRQV ASSQLLTPAE RPGGLDDRSP 1690 1700 1710 PGSSETVELV RYEPDLLRLL GSEVEFQSCN S
	Isoform 2 [UniParc]. Checksum: 08F656081607E8C7	FASTA	1,581	166,958
	10 20 30 40 50 60 MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GDCQHFGSQE FCVSSSFSKV 70 80 90 100 110 120 ELTAVGSGSN ARGADPDGSA TEKLGHKSED KPDDPQPKMD YAGNVAEAEG FLVPLSSPGD 130 140 150 160 170 180 GLKLPASDSA EASNSRADCS WTPLNTQMSK QVDCSPAGVK ALDSRQGVGE KNTFILATLG 190 200 210 220 230 240 TGVPVEGTLP LVTTNFSPLP APICPPAPGS ASVPHSVPDA FQVPLSVPAP VPHSGLVPVQ 250 260 270 280 290 300 VATSVPAPSP PLAPVPALAP APPSVPTLIS DSNPLSVSAS VLVPVPASAP PSGPVPLSAP 310 320 330 340 350 360 APAPLSVPVS APPLALIQAP VPPSAPTLVL APVPTPVLAP MPASTPPAAP APPSVPMPTP 370 380 390 400 410 420 TPSSGPPSTP TLIPAFAPTP VPAPTPAPIF TPAPTPMPAA TPAAIPTSAP IPASFSLSRV 430 440 450 460 470 480 CFPAAQAPAM QKVPLSFQPG TVLTPSQPLV YIPPPSCGQP LSVATLPTTL GVSSTLTLPV 490 500 510 520 530 540 LPSYLQDRCL PGVLASPELR SYPYAFSVAR PLTSDSKLVS LEVNRLPCTS PSGSTTTQPA 550 560 570 580 590 600 PDGVPGPLAD TSLVTASAKV LPTPQPLLPA PSGSSAPPHP AKMPSGTEQQ TEGTSVTFSP 610 620 630 640 650 660 LKSPPQLERE MASPPECSEM PLDLSSKSNR QKLPLPNQRK TPPMPVLTPV HTSSKALLST 670 680 690 700 710 720 VLSRSQRTTQ AAGGNVTSCL GSTSSPFVIF PEIVRNGDPS TWVKNSTALI STIPGTYVGV 730 740 750 760 770 780 ANPVPASLLL NKDPNLGLNR DPRHLPKQEP ISIIDQGEPK GTGATCGKKG SQAGAEGQPS 790 800 810 820 830 840 TVKRYTPARI APGLPGCQTK ELSLWKPTGP ANIYPRCSVN GKPTSTQVLP VGWSPYHQAS 850 860 870 880 890 900 LLSIGISSAG QLTPSQGAPI RPTSVVSEFS GVPSLSSSEA VHGLPEGQPR PGGSFVPEQD 910 920 930 940 950 960 PVTKNKTCRI AAKPYEEQVN PVLLTLSPQT GTLALSVQPS GGDIRMNQGP EESESHLCSD 970 980 990 1000 1010 1020 STPKMEGPQG ACGLKLAGDT KPKNQVLATY MSHELVLATP QNLPKMPELP LLPHDSHPKE 1030 1040 1050 1060 1070 1080 LILDVVPSSR RGSSTERPQL GSQVDLGRVK MEKVDGDVVF NLATCFRADG LPVAPQRGQA 1090 1100 1110 1120 1130 1140 EVRAKAGQAR VKQESVGVFA CKNKWQPDDV TESLPPKKMK CGKEKDSEEQ QLQPQAKAVV 1150 1160 1170 1180 1190 1200 RSSHRPKCRK LPSDPQESTK KSPRGASDSG KEHNGVRGKH KHRKPTKPES QSPGKRADSH 1210 1220 1230 1240 1250 1260 EEGSLEKKAK SSFRDFIPVV LSTRTRSQSD LKARKQKTSS SQSLEHRLRN RNLLLPNKVQ 1270 1280 1290 1300 1310 1320 GISDSPNGFL PNNLEEPACL ENSEKPSGKR KCKTKHMATV SEEAKDVVLY CLQKDSEDVN 1330 1340 1350 1360 1370 1380 HRDNAGYTAL HEACSRGWTD ILNILLEHGA NVNCSAQDGT RPVHDAVVND NLETIWLLLS 1390 1400 1410 1420 1430 1440 YGADPTLATY SGQTAMKLAS SDTMKRFLSD HLSDLQGRAE GDPGVSWDFY SSSVLEEKDG 1450 1460 1470 1480 1490 1500 FACDLLHNPP GSSDQEGDDP MEEDDFMFEL SDKPLLPCYN LQVSVSRGPC NWFLFSDVLK 1510 1520 1530 1540 1550 1560 RLKLSSRIFQ ARFPHFEITT MPKAEFYRQV ASSQLLTPAE RPGGLDDRSP PGSSETVELV 1570 1580 RYEPDLLRLL GSEVEFQSCN S
	Isoform 3 [UniParc]. Checksum: 28D139925EE1E2CD	FASTA	1,785	190,595
	10 20 30 40 50 60 MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GDCQHFGSQE FCVSSSFSKV 70 80 90 100 110 120 ELTAVGSGSN ARGADPDGSA TEKLGHKSED KPDDPQPKMD YAGNVAEAEG FLVPLSSPGD 130 140 150 160 170 180 GLKLPASDSA EASNSRADCS WTPLNTQMSK QVDCSPAGVK ALDSRQGVGE KNTFILATLG 190 200 210 220 230 240 TGVPVEGTLP LVTTNFSPLP APICPPAPGS ASVPHSVPDA FQVPLSVPAP VPHSGLVPVQ 250 260 270 280 290 300 VATSVPAPSP PLAPVPALAP APPSVPTLIS DSNPLSVSAS VLVPVPASAP PSGPVPLSAP 310 320 330 340 350 360 APAPLSVPVS APPLALIQAP VPPSAPTLVL APVPTPVLAP MPASTPPAAP APPSVPMPTP 370 380 390 400 410 420 TPSSGPPSTP TLIPAFAPTP VPAPTPAPIF TPAPTPMPAA TPAAIPTSAP IPASFSLSRV 430 440 450 460 470 480 CFPAAQAPAM QKVPLSFQPG TVLTPSQPLV YIPPPSCGQP LSVATLPTTL GVSSTLTLPV 490 500 510 520 530 540 LPSYLQDRCL PGVLASPELR SYPYAFSVAR PLTSDSKLVS LEVNRLPCTS PSGSTTTQPA 550 560 570 580 590 600 PDGVPGPLAD TSLVTASAKV LPTPQPLLPA PSGSSAPPHP AKMPSGTEQQ TEGTSVTFSP 610 620 630 640 650 660 LKSPPQLERE MASPPECSEM PLDLSSKSNR QKLPLPNQRK TPPMPVLTPV HTSSKALLST 670 680 690 700 710 720 VLSRSQRTTQ AAGGNVTSCL GSTSSPFVIF PEIVRNGDPS TWVKNSTALI STIPGTYVGV 730 740 750 760 770 780 ANPVPASLLL NKDPNLGLNR DPRHLPKQEP ISIIDQGEPK GTGATCGKKG SQAGAEGQPS 790 800 810 820 830 840 TVKRYTPARI APGLPGCQTK ELSLWKPTGP ANIYPRCSVN GKPTSTQVLP VGWSPYHQAS 850 860 870 880 890 900 LLSIGISSAG QLTPSQGAPI RPTSVVSEFS GVPSLSSSEA VHGLPEGQPR PGGSFVPEQD 910 920 930 940 950 960 PVTKNKTCRI AAKPYEEQVN PVLLTLSPQT GTLALSVQPS GGDIRMNQGP EESESHLCSD 970 980 990 1000 1010 1020 STPKMEGPQG ACGLKLAGDT KPKNQVLATY MSHELVLATP QNLPKMPELP LLPHDSHPKE 1030 1040 1050 1060 1070 1080 LILDVVPSSR RGSSTERPQL GSQVDLGRVK MEKVDGDVVF NLATCFRADG LPVAPQRGQA 1090 1100 1110 1120 1130 1140 EVRAKAGQAR VKQESVGVFA CKNKWQPDDV TESLPPKKMK CGKEKDSEEQ QLQPQAKAVV 1150 1160 1170 1180 1190 1200 RSSHRPKCRK LPSDPQESTK KSPRGASDSG KEHNGVRGKH KHRKPTKPES QSPGKRADSH 1210 1220 1230 1240 1250 1260 EEGSLEKKAK SSFRDFIPVV LSTRTRSQSG SICSSFAGMA DSDMGSQEVF PTEEEEEVTP 1270 1280 1290 1300 1310 1320 TPAKRRKVRK TQRDTQYRSH HAQDKSLLSQ GRRHLWRARE MPWRTEAARQ MWDTNEEEEE 1330 1340 1350 1360 1370 1380 EEEEGLLKRK KRRRQKSRKY QTGEYLTEQE DEQRRKGRAD LKARKQKTSS SQSLEHRLRN 1390 1400 1410 1420 1430 1440 RNLLLPNKVQ GISDSPNGFL PNNLEEPACL ENSEKPSGKR KCKTKHMATV SEEAKGKGRW 1450 1460 1470 1480 1490 1500 SQQKTRSPKS PTPVKPTEPC TPSKSRSASS EEASESPTAR QIPPEARRLI VNKNAGETLL 1510 1520 1530 1540 1550 1560 QRAARLGYKD VVLYCLQKDS EDVNHRDNAG YTALHEACSR GWTDILNILL EHGANVNCSA 1570 1580 1590 1600 1610 1620 QDGTRPVHDA VVNDNLETIW LLLSYGADPT LATYSGQTAM KLASSDTMKR FLSDHLSDLQ 1630 1640 1650 1660 1670 1680 GRAEGDPGVS WDFYSSSVLE EKDGFACDLL HNPPGSSDQE GDDPMEEDDF MFELSDKPLL 1690 1700 1710 1720 1730 1740 PCYNLQVSVS RGPCNWFLFS DVLKRLKLSS RIFQARFPHF EITTMPKAEF YRQVASSQLL 1750 1760 1770 1780 TPAERPGGLD DRSPPGSSET VELVRYEPDL LRLLGSEVEF QSCNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
[2]	"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones." Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O. DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-1711 (ISOFORM 1), VARIANT LEU-111. Tissue: Spleen.
[3]	Rhodes S. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 566-1435 (ISOFORM 2).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1265-1711 (ISOFORM 2). Tissue: Amygdala.
[5]	"A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP." Pagan J.K., Arnold J., Hanchard K.J., Kumar R., Bruno T., Jones M.J., Richard D.J., Forrest A., Spurdle A., Verdin E., Crossley M., Fanciulli M., Chenevix-Trench G., Young D.B., Khanna K.K. J. Biol. Chem. 282:15248-15257(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CTBP1; HDAC4; HDAC5 AND HDAC7, MUTAGENESIS OF 623-ASP-LEU-624, TISSUE SPECIFICITY.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613; SER-1033 AND SER-1162, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1476 (ISOFORM 3), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-832.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL034405 Genomic DNA. No translation available. Z82208, AL136450 Genomic DNA. Translation: CAI42768.1. Z82208, AL136450 Genomic DNA. Translation: CAI42769.1. Z82208 Genomic DNA. Translation: CAI42770.1. AL136450, Z82208 Genomic DNA. Translation: CAI42885.1. AL136450, Z82208 Genomic DNA. Translation: CAI42884.1. AK074089 mRNA. Translation: BAB84915.1. AL096777 mRNA. Translation: CAB46626.1. AK124676 mRNA. Translation: BAC85922.1. Different initiation.
IPI	IPI00329707. IPI00386077. IPI00844087.
RefSeq	NP_068765.3. NM_021946.4.
UniGene	Hs.496748.
3D structure databases
HSSP	HSSP built from PDB template 2MYO based on UniProtKB P62775.
ProteinModelPortal	Q5H9F3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000218147.
PTM databases
PhosphoSite	Q5H9F3.
Polymorphism databases
DMDM	74762178.
Proteomic databases
PaxDb	Q5H9F3.
PRIDE	Q5H9F3.
Protocols and materials databases
DNASU	63035.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000218147; ENSP00000218147; ENSG00000085185. ENST00000303743; ENSP00000307541; ENSG00000085185. ENST00000359304; ENSP00000352253; ENSG00000085185. ENST00000456822; ENSP00000399483; ENSG00000085185. ENST00000540052; ENSP00000437775; ENSG00000085185.
GeneID	63035.
KEGG	hsa:63035.
UCSC	uc010nrd.1. human. uc022cdu.1. human.
Organism-specific databases
CTD	63035.
GeneCards	GC0XP129115.
HGNC	HGNC:25657. BCORL1.
HPA	HPA031775. HPA031777.
MIM	300688. gene.
neXtProt	NX_Q5H9F3.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG300696.
HOVERGEN	HBG104815.
InParanoid	Q5H9F3.
OMA	DTKPKNQ.
OrthoDB	EOG4KKZ3H.
PhylomeDB	Q5H9F3.
Gene expression databases
ArrayExpress	Q5H9F3.
Bgee	Q5H9F3.
CleanEx	HS_BCORL1.
Genevestigator	Q5H9F3.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Pfam	PF12796. Ank_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 2 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BCORL1. human.
GenomeRNAi	63035.
NextBio	65531.
SOURCE	Search...

Entry information

Entry name

BCORL_HUMAN

Accession

Primary (citable) accession number: Q5H9F3
Secondary accession number(s): B5MDQ8 , Q5H9F2, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.