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Protein

BCL-6 corepressor-like protein 1

Gene

BCORL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BCL-6 corepressor-like protein 1
Short name:
BCoR-L1
Short name:
BCoR-like protein 1
Gene namesi
Name:BCORL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25657. BCORL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi623 – 624DL → AS: Strongly reduced repressor activity. Interferes with CTBP1 binding. 1 Publication2
Mutagenesisi1665L → D or R: Slightly inhibits interaction with PCGF1. 1 Publication1

Organism-specific databases

DisGeNETi63035.

Polymorphism and mutation databases

BioMutaiBCORL1.
DMDMi74762178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122681 – 1711BCL-6 corepressor-like protein 1Add BLAST1711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei496PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1033PhosphoserineCombined sources1
Cross-linki1092Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1162PhosphoserineCombined sources1
Isoform 3 (identifier: Q5H9F3-3)
Modified residuei1476PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ5H9F3.
PaxDbiQ5H9F3.
PeptideAtlasiQ5H9F3.
PRIDEiQ5H9F3.

PTM databases

iPTMnetiQ5H9F3.
PhosphoSitePlusiQ5H9F3.

Expressioni

Tissue specificityi

Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen.1 Publication

Gene expression databases

BgeeiENSG00000085185.
CleanExiHS_BCORL1.
ExpressionAtlasiQ5H9F3. baseline and differential.
GenevisibleiQ5H9F3. HS.

Organism-specific databases

HPAiHPA031775.
HPA031777.

Interactioni

Subunit structurei

Interacts with CTBP1. Interacts with HDAC4, HDAC5 and HDAC7. Interacts with PCGF1; the interaction is direct.2 Publications

Protein-protein interaction databases

BioGridi121961. 20 interactors.
DIPiDIP-60148N.
IntActiQ5H9F3. 12 interactors.
STRINGi9606.ENSP00000218147.

Structurei

Secondary structure

11711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1596 – 1603Combined sources8
Beta strandi1609 – 1611Combined sources3
Beta strandi1620 – 1624Combined sources5
Helixi1625 – 1632Combined sources8
Helixi1636 – 1642Combined sources7
Beta strandi1648 – 1652Combined sources5
Helixi1653 – 1660Combined sources8
Beta strandi1664 – 1666Combined sources3
Turni1668 – 1670Combined sources3
Beta strandi1686 – 1691Combined sources6
Helixi1694 – 1699Combined sources6
Beta strandi1703 – 1707Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HPMX-ray1.85A/C1594-1711[»]
5JH5X-ray2.55D1594-1711[»]
ProteinModelPortaliQ5H9F3.
SMRiQ5H9F3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1455 – 1484ANK 1Add BLAST30
Repeati1488 – 1517ANK 2Add BLAST30
Repeati1521 – 1549ANK 3Add BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1328 – 1336Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 649Pro-richAdd BLAST452

Sequence similaritiesi

Belongs to the BCOR family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IFKH. Eukaryota.
ENOG411028G. LUCA.
HOVERGENiHBG104815.
InParanoidiQ5H9F3.
OrthoDBiEOG091G0R1A.
PhylomeDBiQ5H9F3.
TreeFamiTF333317.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR031628. BCOR.
IPR032365. PUFD.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF15808. BCOR. 1 hit.
PF16553. PUFD. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5H9F3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GDCQHFGSQE
60 70 80 90 100
FCVSSSFSKV ELTAVGSGSN ARGADPDGSA TEKLGHKSED KPDDPQPKMD
110 120 130 140 150
YAGNVAEAEG FLVPLSSPGD GLKLPASDSA EASNSRADCS WTPLNTQMSK
160 170 180 190 200
QVDCSPAGVK ALDSRQGVGE KNTFILATLG TGVPVEGTLP LVTTNFSPLP
210 220 230 240 250
APICPPAPGS ASVPHSVPDA FQVPLSVPAP VPHSGLVPVQ VATSVPAPSP
260 270 280 290 300
PLAPVPALAP APPSVPTLIS DSNPLSVSAS VLVPVPASAP PSGPVPLSAP
310 320 330 340 350
APAPLSVPVS APPLALIQAP VPPSAPTLVL APVPTPVLAP MPASTPPAAP
360 370 380 390 400
APPSVPMPTP TPSSGPPSTP TLIPAFAPTP VPAPTPAPIF TPAPTPMPAA
410 420 430 440 450
TPAAIPTSAP IPASFSLSRV CFPAAQAPAM QKVPLSFQPG TVLTPSQPLV
460 470 480 490 500
YIPPPSCGQP LSVATLPTTL GVSSTLTLPV LPSYLQDRCL PGVLASPELR
510 520 530 540 550
SYPYAFSVAR PLTSDSKLVS LEVNRLPCTS PSGSTTTQPA PDGVPGPLAD
560 570 580 590 600
TSLVTASAKV LPTPQPLLPA PSGSSAPPHP AKMPSGTEQQ TEGTSVTFSP
610 620 630 640 650
LKSPPQLERE MASPPECSEM PLDLSSKSNR QKLPLPNQRK TPPMPVLTPV
660 670 680 690 700
HTSSKALLST VLSRSQRTTQ AAGGNVTSCL GSTSSPFVIF PEIVRNGDPS
710 720 730 740 750
TWVKNSTALI STIPGTYVGV ANPVPASLLL NKDPNLGLNR DPRHLPKQEP
760 770 780 790 800
ISIIDQGEPK GTGATCGKKG SQAGAEGQPS TVKRYTPARI APGLPGCQTK
810 820 830 840 850
ELSLWKPTGP ANIYPRCSVN GKPTSTQVLP VGWSPYHQAS LLSIGISSAG
860 870 880 890 900
QLTPSQGAPI RPTSVVSEFS GVPSLSSSEA VHGLPEGQPR PGGSFVPEQD
910 920 930 940 950
PVTKNKTCRI AAKPYEEQVN PVLLTLSPQT GTLALSVQPS GGDIRMNQGP
960 970 980 990 1000
EESESHLCSD STPKMEGPQG ACGLKLAGDT KPKNQVLATY MSHELVLATP
1010 1020 1030 1040 1050
QNLPKMPELP LLPHDSHPKE LILDVVPSSR RGSSTERPQL GSQVDLGRVK
1060 1070 1080 1090 1100
MEKVDGDVVF NLATCFRADG LPVAPQRGQA EVRAKAGQAR VKQESVGVFA
1110 1120 1130 1140 1150
CKNKWQPDDV TESLPPKKMK CGKEKDSEEQ QLQPQAKAVV RSSHRPKCRK
1160 1170 1180 1190 1200
LPSDPQESTK KSPRGASDSG KEHNGVRGKH KHRKPTKPES QSPGKRADSH
1210 1220 1230 1240 1250
EEGSLEKKAK SSFRDFIPVV LSTRTRSQSG SICSSFAGMA DSDMGSQEVF
1260 1270 1280 1290 1300
PTEEEEEVTP TPAKRRKVRK TQRDTQYRSH HAQDKSLLSQ GRRHLWRARE
1310 1320 1330 1340 1350
MPWRTEAARQ MWDTNEEEEE EEEEGLLKRK KRRRQKSRKY QTGEYLTEQE
1360 1370 1380 1390 1400
DEQRRKGRAD LKARKQKTSS SQSLEHRLRN RNLLLPNKVQ GISDSPNGFL
1410 1420 1430 1440 1450
PNNLEEPACL ENSEKPSGKR KCKTKHMATV SEEAKDVVLY CLQKDSEDVN
1460 1470 1480 1490 1500
HRDNAGYTAL HEACSRGWTD ILNILLEHGA NVNCSAQDGT RPVHDAVVND
1510 1520 1530 1540 1550
NLETIWLLLS YGADPTLATY SGQTAMKLAS SDTMKRFLSD HLSDLQGRAE
1560 1570 1580 1590 1600
GDPGVSWDFY SSSVLEEKDG FACDLLHNPP GSSDQEGDDP MEEDDFMFEL
1610 1620 1630 1640 1650
SDKPLLPCYN LQVSVSRGPC NWFLFSDVLK RLKLSSRIFQ ARFPHFEITT
1660 1670 1680 1690 1700
MPKAEFYRQV ASSQLLTPAE RPGGLDDRSP PGSSETVELV RYEPDLLRLL
1710
GSEVEFQSCN S
Length:1,711
Mass (Da):182,526
Last modified:February 15, 2005 - v1
Checksum:iDD78A00598703C53
GO
Isoform 2 (identifier: Q5H9F3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1230-1359: Missing.

Show »
Length:1,581
Mass (Da):166,958
Checksum:i08F656081607E8C7
GO
Isoform 3 (identifier: Q5H9F3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1434-1434: A → AKGKGRWSQQ...LLQRAARLGY

Show »
Length:1,785
Mass (Da):190,595
Checksum:i28D139925EE1E2CD
GO

Sequence cautioni

The sequence BAC85922 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1564V → A in BAC85922 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061020111F → L.1 PublicationCorresponds to variant rs4830173dbSNPEnsembl.1
Natural variantiVAR_037467209G → S.Corresponds to variant rs5932715dbSNPEnsembl.1
Natural variantiVAR_070559820N → S Found in a patient with severe intellectual disability, coarse face and hypotonia; unknown pathological significance. 1 Publication1
Natural variantiVAR_037468832G → D in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0297781230 – 1359Missing in isoform 2. 2 PublicationsAdd BLAST130
Alternative sequenceiVSP_0297791434A → AKGKGRWSQQKTRSPKSPTP VKPTEPCTPSKSRSASSEEA SESPTARQIPPEARRLIVNK NAGETLLQRAARLGY in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034405 Genomic DNA. No translation available.
Z82208, AL136450 Genomic DNA. Translation: CAI42768.1.
Z82208, AL136450 Genomic DNA. Translation: CAI42769.1.
Z82208 Genomic DNA. Translation: CAI42770.1.
AL136450, Z82208 Genomic DNA. Translation: CAI42885.1.
AL136450, Z82208 Genomic DNA. Translation: CAI42884.1.
AK074089 mRNA. Translation: BAB84915.1.
AL096777 mRNA. Translation: CAB46626.1.
AK124676 mRNA. Translation: BAC85922.1. Different initiation.
CCDSiCCDS14616.1. [Q5H9F3-1]
RefSeqiNP_068765.3. NM_021946.4.
UniGeneiHs.496748.

Genome annotation databases

EnsembliENST00000218147; ENSP00000218147; ENSG00000085185.
ENST00000540052; ENSP00000437775; ENSG00000085185.
GeneIDi63035.
KEGGihsa:63035.
UCSCiuc022cdu.1. human. [Q5H9F3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034405 Genomic DNA. No translation available.
Z82208, AL136450 Genomic DNA. Translation: CAI42768.1.
Z82208, AL136450 Genomic DNA. Translation: CAI42769.1.
Z82208 Genomic DNA. Translation: CAI42770.1.
AL136450, Z82208 Genomic DNA. Translation: CAI42885.1.
AL136450, Z82208 Genomic DNA. Translation: CAI42884.1.
AK074089 mRNA. Translation: BAB84915.1.
AL096777 mRNA. Translation: CAB46626.1.
AK124676 mRNA. Translation: BAC85922.1. Different initiation.
CCDSiCCDS14616.1. [Q5H9F3-1]
RefSeqiNP_068765.3. NM_021946.4.
UniGeneiHs.496748.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HPMX-ray1.85A/C1594-1711[»]
5JH5X-ray2.55D1594-1711[»]
ProteinModelPortaliQ5H9F3.
SMRiQ5H9F3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121961. 20 interactors.
DIPiDIP-60148N.
IntActiQ5H9F3. 12 interactors.
STRINGi9606.ENSP00000218147.

PTM databases

iPTMnetiQ5H9F3.
PhosphoSitePlusiQ5H9F3.

Polymorphism and mutation databases

BioMutaiBCORL1.
DMDMi74762178.

Proteomic databases

MaxQBiQ5H9F3.
PaxDbiQ5H9F3.
PeptideAtlasiQ5H9F3.
PRIDEiQ5H9F3.

Protocols and materials databases

DNASUi63035.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218147; ENSP00000218147; ENSG00000085185.
ENST00000540052; ENSP00000437775; ENSG00000085185.
GeneIDi63035.
KEGGihsa:63035.
UCSCiuc022cdu.1. human. [Q5H9F3-1]

Organism-specific databases

CTDi63035.
DisGeNETi63035.
GeneCardsiBCORL1.
HGNCiHGNC:25657. BCORL1.
HPAiHPA031775.
HPA031777.
MIMi300688. gene.
neXtProtiNX_Q5H9F3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFKH. Eukaryota.
ENOG411028G. LUCA.
HOVERGENiHBG104815.
InParanoidiQ5H9F3.
OrthoDBiEOG091G0R1A.
PhylomeDBiQ5H9F3.
TreeFamiTF333317.

Miscellaneous databases

ChiTaRSiBCORL1. human.
GenomeRNAii63035.
PROiQ5H9F3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000085185.
CleanExiHS_BCORL1.
ExpressionAtlasiQ5H9F3. baseline and differential.
GenevisibleiQ5H9F3. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR031628. BCOR.
IPR032365. PUFD.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF15808. BCOR. 1 hit.
PF16553. PUFD. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCORL_HUMAN
AccessioniPrimary (citable) accession number: Q5H9F3
Secondary accession number(s): B5MDQ8
, Q5H9F2, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.