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Q5H9F3

- BCORL_HUMAN

UniProt

Q5H9F3 - BCORL_HUMAN

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Protein

BCL-6 corepressor-like protein 1

Gene

BCORL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.1 Publication

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BCL-6 corepressor-like protein 1
Short name:
BCoR-L1
Short name:
BCoR-like protein 1
Gene namesi
Name:BCORL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:25657. BCORL1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi623 – 6242DL → AS: Strongly reduced repressor activity. Interferes with CTBP1 binding. 1 Publication
Mutagenesisi1665 – 16651L → D or R: Slightly inhibits interaction with PCGF1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17111711BCL-6 corepressor-like protein 1PRO_0000312268Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei613 – 6131Phosphoserine1 Publication
Modified residuei1033 – 10331Phosphoserine1 Publication
Modified residuei1162 – 11621Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5H9F3.
PaxDbiQ5H9F3.
PRIDEiQ5H9F3.

PTM databases

PhosphoSiteiQ5H9F3.

Expressioni

Tissue specificityi

Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen.1 Publication

Gene expression databases

BgeeiQ5H9F3.
CleanExiHS_BCORL1.
ExpressionAtlasiQ5H9F3. baseline and differential.
GenevestigatoriQ5H9F3.

Organism-specific databases

HPAiHPA031775.
HPA031777.

Interactioni

Subunit structurei

Interacts with CTBP1. Interacts with HDAC4, HDAC5 and HDAC7. Interacts with PCGF1; the interaction is direct.2 Publications

Protein-protein interaction databases

BioGridi121961. 13 interactions.
DIPiDIP-60148N.
STRINGi9606.ENSP00000218147.

Structurei

Secondary structure

1
1711
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1596 – 16038
Beta strandi1609 – 16113
Beta strandi1620 – 16245
Helixi1625 – 16328
Helixi1636 – 16427
Beta strandi1648 – 16525
Helixi1653 – 16608
Beta strandi1664 – 16663
Turni1668 – 16703
Beta strandi1686 – 16916
Helixi1694 – 16996
Beta strandi1703 – 17075

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HPMX-ray1.85A/C1594-1711[»]
ProteinModelPortaliQ5H9F3.
SMRiQ5H9F3. Positions 1410-1552, 1594-1711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1455 – 148430ANK 1Add
BLAST
Repeati1488 – 151730ANK 2Add
BLAST
Repeati1521 – 154929ANK 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1328 – 13369Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 649452Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the BCOR family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG300696.
HOVERGENiHBG104815.
InParanoidiQ5H9F3.
OMAiSPFVIFP.
OrthoDBiEOG7KWSGQ.
PhylomeDBiQ5H9F3.
TreeFamiTF333317.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5H9F3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GDCQHFGSQE
60 70 80 90 100
FCVSSSFSKV ELTAVGSGSN ARGADPDGSA TEKLGHKSED KPDDPQPKMD
110 120 130 140 150
YAGNVAEAEG FLVPLSSPGD GLKLPASDSA EASNSRADCS WTPLNTQMSK
160 170 180 190 200
QVDCSPAGVK ALDSRQGVGE KNTFILATLG TGVPVEGTLP LVTTNFSPLP
210 220 230 240 250
APICPPAPGS ASVPHSVPDA FQVPLSVPAP VPHSGLVPVQ VATSVPAPSP
260 270 280 290 300
PLAPVPALAP APPSVPTLIS DSNPLSVSAS VLVPVPASAP PSGPVPLSAP
310 320 330 340 350
APAPLSVPVS APPLALIQAP VPPSAPTLVL APVPTPVLAP MPASTPPAAP
360 370 380 390 400
APPSVPMPTP TPSSGPPSTP TLIPAFAPTP VPAPTPAPIF TPAPTPMPAA
410 420 430 440 450
TPAAIPTSAP IPASFSLSRV CFPAAQAPAM QKVPLSFQPG TVLTPSQPLV
460 470 480 490 500
YIPPPSCGQP LSVATLPTTL GVSSTLTLPV LPSYLQDRCL PGVLASPELR
510 520 530 540 550
SYPYAFSVAR PLTSDSKLVS LEVNRLPCTS PSGSTTTQPA PDGVPGPLAD
560 570 580 590 600
TSLVTASAKV LPTPQPLLPA PSGSSAPPHP AKMPSGTEQQ TEGTSVTFSP
610 620 630 640 650
LKSPPQLERE MASPPECSEM PLDLSSKSNR QKLPLPNQRK TPPMPVLTPV
660 670 680 690 700
HTSSKALLST VLSRSQRTTQ AAGGNVTSCL GSTSSPFVIF PEIVRNGDPS
710 720 730 740 750
TWVKNSTALI STIPGTYVGV ANPVPASLLL NKDPNLGLNR DPRHLPKQEP
760 770 780 790 800
ISIIDQGEPK GTGATCGKKG SQAGAEGQPS TVKRYTPARI APGLPGCQTK
810 820 830 840 850
ELSLWKPTGP ANIYPRCSVN GKPTSTQVLP VGWSPYHQAS LLSIGISSAG
860 870 880 890 900
QLTPSQGAPI RPTSVVSEFS GVPSLSSSEA VHGLPEGQPR PGGSFVPEQD
910 920 930 940 950
PVTKNKTCRI AAKPYEEQVN PVLLTLSPQT GTLALSVQPS GGDIRMNQGP
960 970 980 990 1000
EESESHLCSD STPKMEGPQG ACGLKLAGDT KPKNQVLATY MSHELVLATP
1010 1020 1030 1040 1050
QNLPKMPELP LLPHDSHPKE LILDVVPSSR RGSSTERPQL GSQVDLGRVK
1060 1070 1080 1090 1100
MEKVDGDVVF NLATCFRADG LPVAPQRGQA EVRAKAGQAR VKQESVGVFA
1110 1120 1130 1140 1150
CKNKWQPDDV TESLPPKKMK CGKEKDSEEQ QLQPQAKAVV RSSHRPKCRK
1160 1170 1180 1190 1200
LPSDPQESTK KSPRGASDSG KEHNGVRGKH KHRKPTKPES QSPGKRADSH
1210 1220 1230 1240 1250
EEGSLEKKAK SSFRDFIPVV LSTRTRSQSG SICSSFAGMA DSDMGSQEVF
1260 1270 1280 1290 1300
PTEEEEEVTP TPAKRRKVRK TQRDTQYRSH HAQDKSLLSQ GRRHLWRARE
1310 1320 1330 1340 1350
MPWRTEAARQ MWDTNEEEEE EEEEGLLKRK KRRRQKSRKY QTGEYLTEQE
1360 1370 1380 1390 1400
DEQRRKGRAD LKARKQKTSS SQSLEHRLRN RNLLLPNKVQ GISDSPNGFL
1410 1420 1430 1440 1450
PNNLEEPACL ENSEKPSGKR KCKTKHMATV SEEAKDVVLY CLQKDSEDVN
1460 1470 1480 1490 1500
HRDNAGYTAL HEACSRGWTD ILNILLEHGA NVNCSAQDGT RPVHDAVVND
1510 1520 1530 1540 1550
NLETIWLLLS YGADPTLATY SGQTAMKLAS SDTMKRFLSD HLSDLQGRAE
1560 1570 1580 1590 1600
GDPGVSWDFY SSSVLEEKDG FACDLLHNPP GSSDQEGDDP MEEDDFMFEL
1610 1620 1630 1640 1650
SDKPLLPCYN LQVSVSRGPC NWFLFSDVLK RLKLSSRIFQ ARFPHFEITT
1660 1670 1680 1690 1700
MPKAEFYRQV ASSQLLTPAE RPGGLDDRSP PGSSETVELV RYEPDLLRLL
1710
GSEVEFQSCN S
Length:1,711
Mass (Da):182,526
Last modified:February 15, 2005 - v1
Checksum:iDD78A00598703C53
GO
Isoform 2 (identifier: Q5H9F3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1230-1359: Missing.

Show »
Length:1,581
Mass (Da):166,958
Checksum:i08F656081607E8C7
GO
Isoform 3 (identifier: Q5H9F3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1434-1434: A → AKGKGRWSQQ...LLQRAARLGY

Note: Contains a phosphoserine at position 1476.

Show »
Length:1,785
Mass (Da):190,595
Checksum:i28D139925EE1E2CD
GO

Sequence cautioni

The sequence BAC85922.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1564 – 15641V → A in BAC85922. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111F → L.1 Publication
Corresponds to variant rs4830173 [ dbSNP | Ensembl ].
VAR_061020
Natural varianti209 – 2091G → S.
Corresponds to variant rs5932715 [ dbSNP | Ensembl ].
VAR_037467
Natural varianti820 – 8201N → S Found in a patient with severe intellectual disability, coarse face and hypotonia; unknown pathological significance. 1 Publication
VAR_070559
Natural varianti832 – 8321G → D in a breast cancer sample; somatic mutation. 1 Publication
VAR_037468

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1230 – 1359130Missing in isoform 2. 2 PublicationsVSP_029778Add
BLAST
Alternative sequencei1434 – 14341A → AKGKGRWSQQKTRSPKSPTP VKPTEPCTPSKSRSASSEEA SESPTARQIPPEARRLIVNK NAGETLLQRAARLGY in isoform 3. CuratedVSP_029779

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL034405 Genomic DNA. No translation available.
Z82208, AL136450 Genomic DNA. Translation: CAI42768.1.
Z82208, AL136450 Genomic DNA. Translation: CAI42769.1.
Z82208 Genomic DNA. Translation: CAI42770.1.
AL136450, Z82208 Genomic DNA. Translation: CAI42885.1.
AL136450, Z82208 Genomic DNA. Translation: CAI42884.1.
AK074089 mRNA. Translation: BAB84915.1.
AL096777 mRNA. Translation: CAB46626.1.
AK124676 mRNA. Translation: BAC85922.1. Different initiation.
CCDSiCCDS14616.1. [Q5H9F3-1]
RefSeqiNP_068765.3. NM_021946.4.
UniGeneiHs.496748.

Genome annotation databases

EnsembliENST00000218147; ENSP00000218147; ENSG00000085185.
ENST00000540052; ENSP00000437775; ENSG00000085185.
GeneIDi63035.
KEGGihsa:63035.
UCSCiuc010nrd.1. human. [Q5H9F3-2]
uc022cdu.1. human. [Q5H9F3-1]

Polymorphism databases

DMDMi74762178.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL034405 Genomic DNA. No translation available.
Z82208 , AL136450 Genomic DNA. Translation: CAI42768.1 .
Z82208 , AL136450 Genomic DNA. Translation: CAI42769.1 .
Z82208 Genomic DNA. Translation: CAI42770.1 .
AL136450 , Z82208 Genomic DNA. Translation: CAI42885.1 .
AL136450 , Z82208 Genomic DNA. Translation: CAI42884.1 .
AK074089 mRNA. Translation: BAB84915.1 .
AL096777 mRNA. Translation: CAB46626.1 .
AK124676 mRNA. Translation: BAC85922.1 . Different initiation.
CCDSi CCDS14616.1. [Q5H9F3-1 ]
RefSeqi NP_068765.3. NM_021946.4.
UniGenei Hs.496748.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HPM X-ray 1.85 A/C 1594-1711 [» ]
ProteinModelPortali Q5H9F3.
SMRi Q5H9F3. Positions 1410-1552, 1594-1711.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121961. 13 interactions.
DIPi DIP-60148N.
STRINGi 9606.ENSP00000218147.

PTM databases

PhosphoSitei Q5H9F3.

Polymorphism databases

DMDMi 74762178.

Proteomic databases

MaxQBi Q5H9F3.
PaxDbi Q5H9F3.
PRIDEi Q5H9F3.

Protocols and materials databases

DNASUi 63035.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000218147 ; ENSP00000218147 ; ENSG00000085185 .
ENST00000540052 ; ENSP00000437775 ; ENSG00000085185 .
GeneIDi 63035.
KEGGi hsa:63035.
UCSCi uc010nrd.1. human. [Q5H9F3-2 ]
uc022cdu.1. human. [Q5H9F3-1 ]

Organism-specific databases

CTDi 63035.
GeneCardsi GC0XP129115.
HGNCi HGNC:25657. BCORL1.
HPAi HPA031775.
HPA031777.
MIMi 300688. gene.
neXtProti NX_Q5H9F3.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300696.
HOVERGENi HBG104815.
InParanoidi Q5H9F3.
OMAi SPFVIFP.
OrthoDBi EOG7KWSGQ.
PhylomeDBi Q5H9F3.
TreeFami TF333317.

Miscellaneous databases

ChiTaRSi BCORL1. human.
GenomeRNAii 63035.
NextBioi 65531.
PROi Q5H9F3.
SOURCEi Search...

Gene expression databases

Bgeei Q5H9F3.
CleanExi HS_BCORL1.
ExpressionAtlasi Q5H9F3. baseline and differential.
Genevestigatori Q5H9F3.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
  2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-1711 (ISOFORM 1), VARIANT LEU-111.
    Tissue: Spleen.
  3. Rhodes S.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 566-1435 (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1265-1711 (ISOFORM 2).
    Tissue: Amygdala.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CTBP1; HDAC4; HDAC5 AND HDAC7, MUTAGENESIS OF 623-ASP-LEU-624, TISSUE SPECIFICITY.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613; SER-1033 AND SER-1162, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1476 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs."
    Junco S.E., Wang R., Gaipa J.C., Taylor A.B., Schirf V., Gearhart M.D., Bardwell V.J., Demeler B., Hart P.J., Kim C.A.
    Structure 21:665-671(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1634-1748 IN COMPLEX WITH PCGF1, INTERACTION WITH PCGF1, MUTAGENESIS OF LEU-1665.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-832.
  9. Cited for: VARIANT SER-820.

Entry informationi

Entry nameiBCORL_HUMAN
AccessioniPrimary (citable) accession number: Q5H9F3
Secondary accession number(s): B5MDQ8
, Q5H9F2, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3