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Q5H9F3

- BCORL_HUMAN

UniProt

Q5H9F3 - BCORL_HUMAN

Protein

BCL-6 corepressor-like protein 1

Gene

BCORL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.1 Publication

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BCL-6 corepressor-like protein 1
    Short name:
    BCoR-L1
    Short name:
    BCoR-like protein 1
    Gene namesi
    Name:BCORL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:25657. BCORL1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi623 – 6242DL → AS: Strongly reduced repressor activity. Interferes with CTBP1 binding. 1 Publication
    Mutagenesisi1665 – 16651L → D or R: Slightly inhibits interaction with PCGF1. 2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17111711BCL-6 corepressor-like protein 1PRO_0000312268Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei613 – 6131Phosphoserine1 Publication
    Modified residuei1033 – 10331Phosphoserine1 Publication
    Modified residuei1162 – 11621Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5H9F3.
    PaxDbiQ5H9F3.
    PRIDEiQ5H9F3.

    PTM databases

    PhosphoSiteiQ5H9F3.

    Expressioni

    Tissue specificityi

    Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen.1 Publication

    Gene expression databases

    ArrayExpressiQ5H9F3.
    BgeeiQ5H9F3.
    CleanExiHS_BCORL1.
    GenevestigatoriQ5H9F3.

    Organism-specific databases

    HPAiHPA031775.
    HPA031777.

    Interactioni

    Subunit structurei

    Interacts with CTBP1. Interacts with HDAC4, HDAC5 and HDAC7. Interacts with PCGF1; the interaction is direct.2 Publications

    Protein-protein interaction databases

    BioGridi121961. 12 interactions.
    DIPiDIP-60148N.
    STRINGi9606.ENSP00000218147.

    Structurei

    Secondary structure

    1
    1711
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1596 – 16038
    Beta strandi1609 – 16113
    Beta strandi1620 – 16245
    Helixi1625 – 16328
    Helixi1636 – 16427
    Beta strandi1648 – 16525
    Helixi1653 – 16608
    Beta strandi1664 – 16663
    Turni1668 – 16703
    Beta strandi1686 – 16916
    Helixi1694 – 16996
    Beta strandi1703 – 17075

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HPMX-ray1.85A/C1594-1711[»]
    ProteinModelPortaliQ5H9F3.
    SMRiQ5H9F3. Positions 1410-1543, 1594-1711.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1455 – 148430ANK 1Add
    BLAST
    Repeati1488 – 151730ANK 2Add
    BLAST
    Repeati1521 – 154929ANK 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1328 – 13369Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi198 – 649452Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BCOR family.Curated
    Contains 3 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG300696.
    HOVERGENiHBG104815.
    InParanoidiQ5H9F3.
    OMAiSPFVIFP.
    OrthoDBiEOG7KWSGQ.
    PhylomeDBiQ5H9F3.
    TreeFamiTF333317.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5H9F3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GDCQHFGSQE     50
    FCVSSSFSKV ELTAVGSGSN ARGADPDGSA TEKLGHKSED KPDDPQPKMD 100
    YAGNVAEAEG FLVPLSSPGD GLKLPASDSA EASNSRADCS WTPLNTQMSK 150
    QVDCSPAGVK ALDSRQGVGE KNTFILATLG TGVPVEGTLP LVTTNFSPLP 200
    APICPPAPGS ASVPHSVPDA FQVPLSVPAP VPHSGLVPVQ VATSVPAPSP 250
    PLAPVPALAP APPSVPTLIS DSNPLSVSAS VLVPVPASAP PSGPVPLSAP 300
    APAPLSVPVS APPLALIQAP VPPSAPTLVL APVPTPVLAP MPASTPPAAP 350
    APPSVPMPTP TPSSGPPSTP TLIPAFAPTP VPAPTPAPIF TPAPTPMPAA 400
    TPAAIPTSAP IPASFSLSRV CFPAAQAPAM QKVPLSFQPG TVLTPSQPLV 450
    YIPPPSCGQP LSVATLPTTL GVSSTLTLPV LPSYLQDRCL PGVLASPELR 500
    SYPYAFSVAR PLTSDSKLVS LEVNRLPCTS PSGSTTTQPA PDGVPGPLAD 550
    TSLVTASAKV LPTPQPLLPA PSGSSAPPHP AKMPSGTEQQ TEGTSVTFSP 600
    LKSPPQLERE MASPPECSEM PLDLSSKSNR QKLPLPNQRK TPPMPVLTPV 650
    HTSSKALLST VLSRSQRTTQ AAGGNVTSCL GSTSSPFVIF PEIVRNGDPS 700
    TWVKNSTALI STIPGTYVGV ANPVPASLLL NKDPNLGLNR DPRHLPKQEP 750
    ISIIDQGEPK GTGATCGKKG SQAGAEGQPS TVKRYTPARI APGLPGCQTK 800
    ELSLWKPTGP ANIYPRCSVN GKPTSTQVLP VGWSPYHQAS LLSIGISSAG 850
    QLTPSQGAPI RPTSVVSEFS GVPSLSSSEA VHGLPEGQPR PGGSFVPEQD 900
    PVTKNKTCRI AAKPYEEQVN PVLLTLSPQT GTLALSVQPS GGDIRMNQGP 950
    EESESHLCSD STPKMEGPQG ACGLKLAGDT KPKNQVLATY MSHELVLATP 1000
    QNLPKMPELP LLPHDSHPKE LILDVVPSSR RGSSTERPQL GSQVDLGRVK 1050
    MEKVDGDVVF NLATCFRADG LPVAPQRGQA EVRAKAGQAR VKQESVGVFA 1100
    CKNKWQPDDV TESLPPKKMK CGKEKDSEEQ QLQPQAKAVV RSSHRPKCRK 1150
    LPSDPQESTK KSPRGASDSG KEHNGVRGKH KHRKPTKPES QSPGKRADSH 1200
    EEGSLEKKAK SSFRDFIPVV LSTRTRSQSG SICSSFAGMA DSDMGSQEVF 1250
    PTEEEEEVTP TPAKRRKVRK TQRDTQYRSH HAQDKSLLSQ GRRHLWRARE 1300
    MPWRTEAARQ MWDTNEEEEE EEEEGLLKRK KRRRQKSRKY QTGEYLTEQE 1350
    DEQRRKGRAD LKARKQKTSS SQSLEHRLRN RNLLLPNKVQ GISDSPNGFL 1400
    PNNLEEPACL ENSEKPSGKR KCKTKHMATV SEEAKDVVLY CLQKDSEDVN 1450
    HRDNAGYTAL HEACSRGWTD ILNILLEHGA NVNCSAQDGT RPVHDAVVND 1500
    NLETIWLLLS YGADPTLATY SGQTAMKLAS SDTMKRFLSD HLSDLQGRAE 1550
    GDPGVSWDFY SSSVLEEKDG FACDLLHNPP GSSDQEGDDP MEEDDFMFEL 1600
    SDKPLLPCYN LQVSVSRGPC NWFLFSDVLK RLKLSSRIFQ ARFPHFEITT 1650
    MPKAEFYRQV ASSQLLTPAE RPGGLDDRSP PGSSETVELV RYEPDLLRLL 1700
    GSEVEFQSCN S 1711
    Length:1,711
    Mass (Da):182,526
    Last modified:February 15, 2005 - v1
    Checksum:iDD78A00598703C53
    GO
    Isoform 2 (identifier: Q5H9F3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1230-1359: Missing.

    Show »
    Length:1,581
    Mass (Da):166,958
    Checksum:i08F656081607E8C7
    GO
    Isoform 3 (identifier: Q5H9F3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1434-1434: A → AKGKGRWSQQ...LLQRAARLGY

    Note: Contains a phosphoserine at position 1476.

    Show »
    Length:1,785
    Mass (Da):190,595
    Checksum:i28D139925EE1E2CD
    GO

    Sequence cautioni

    The sequence BAC85922.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1564 – 15641V → A in BAC85922. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti111 – 1111F → L.1 Publication
    Corresponds to variant rs4830173 [ dbSNP | Ensembl ].
    VAR_061020
    Natural varianti209 – 2091G → S.
    Corresponds to variant rs5932715 [ dbSNP | Ensembl ].
    VAR_037467
    Natural varianti820 – 8201N → S Found in a patient with severe intellectual disability, coarse face and hypotonia; unknown pathological significance. 1 Publication
    VAR_070559
    Natural varianti832 – 8321G → D in a breast cancer sample; somatic mutation. 1 Publication
    VAR_037468

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1230 – 1359130Missing in isoform 2. 2 PublicationsVSP_029778Add
    BLAST
    Alternative sequencei1434 – 14341A → AKGKGRWSQQKTRSPKSPTP VKPTEPCTPSKSRSASSEEA SESPTARQIPPEARRLIVNK NAGETLLQRAARLGY in isoform 3. CuratedVSP_029779

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL034405 Genomic DNA. No translation available.
    Z82208, AL136450 Genomic DNA. Translation: CAI42768.1.
    Z82208, AL136450 Genomic DNA. Translation: CAI42769.1.
    Z82208 Genomic DNA. Translation: CAI42770.1.
    AL136450, Z82208 Genomic DNA. Translation: CAI42885.1.
    AL136450, Z82208 Genomic DNA. Translation: CAI42884.1.
    AK074089 mRNA. Translation: BAB84915.1.
    AL096777 mRNA. Translation: CAB46626.1.
    AK124676 mRNA. Translation: BAC85922.1. Different initiation.
    CCDSiCCDS14616.1. [Q5H9F3-1]
    RefSeqiNP_068765.3. NM_021946.4.
    UniGeneiHs.496748.

    Genome annotation databases

    EnsembliENST00000218147; ENSP00000218147; ENSG00000085185. [Q5H9F3-1]
    ENST00000540052; ENSP00000437775; ENSG00000085185. [Q5H9F3-1]
    GeneIDi63035.
    KEGGihsa:63035.
    UCSCiuc010nrd.1. human. [Q5H9F3-2]
    uc022cdu.1. human. [Q5H9F3-1]

    Polymorphism databases

    DMDMi74762178.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL034405 Genomic DNA. No translation available.
    Z82208 , AL136450 Genomic DNA. Translation: CAI42768.1 .
    Z82208 , AL136450 Genomic DNA. Translation: CAI42769.1 .
    Z82208 Genomic DNA. Translation: CAI42770.1 .
    AL136450 , Z82208 Genomic DNA. Translation: CAI42885.1 .
    AL136450 , Z82208 Genomic DNA. Translation: CAI42884.1 .
    AK074089 mRNA. Translation: BAB84915.1 .
    AL096777 mRNA. Translation: CAB46626.1 .
    AK124676 mRNA. Translation: BAC85922.1 . Different initiation.
    CCDSi CCDS14616.1. [Q5H9F3-1 ]
    RefSeqi NP_068765.3. NM_021946.4.
    UniGenei Hs.496748.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HPM X-ray 1.85 A/C 1594-1711 [» ]
    ProteinModelPortali Q5H9F3.
    SMRi Q5H9F3. Positions 1410-1543, 1594-1711.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121961. 12 interactions.
    DIPi DIP-60148N.
    STRINGi 9606.ENSP00000218147.

    PTM databases

    PhosphoSitei Q5H9F3.

    Polymorphism databases

    DMDMi 74762178.

    Proteomic databases

    MaxQBi Q5H9F3.
    PaxDbi Q5H9F3.
    PRIDEi Q5H9F3.

    Protocols and materials databases

    DNASUi 63035.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000218147 ; ENSP00000218147 ; ENSG00000085185 . [Q5H9F3-1 ]
    ENST00000540052 ; ENSP00000437775 ; ENSG00000085185 . [Q5H9F3-1 ]
    GeneIDi 63035.
    KEGGi hsa:63035.
    UCSCi uc010nrd.1. human. [Q5H9F3-2 ]
    uc022cdu.1. human. [Q5H9F3-1 ]

    Organism-specific databases

    CTDi 63035.
    GeneCardsi GC0XP129115.
    HGNCi HGNC:25657. BCORL1.
    HPAi HPA031775.
    HPA031777.
    MIMi 300688. gene.
    neXtProti NX_Q5H9F3.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300696.
    HOVERGENi HBG104815.
    InParanoidi Q5H9F3.
    OMAi SPFVIFP.
    OrthoDBi EOG7KWSGQ.
    PhylomeDBi Q5H9F3.
    TreeFami TF333317.

    Miscellaneous databases

    ChiTaRSi BCORL1. human.
    GenomeRNAii 63035.
    NextBioi 65531.
    PROi Q5H9F3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5H9F3.
    Bgeei Q5H9F3.
    CleanExi HS_BCORL1.
    Genevestigatori Q5H9F3.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
      Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
      DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-1711 (ISOFORM 1), VARIANT LEU-111.
      Tissue: Spleen.
    3. Rhodes S.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 566-1435 (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1265-1711 (ISOFORM 2).
      Tissue: Amygdala.
    5. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CTBP1; HDAC4; HDAC5 AND HDAC7, MUTAGENESIS OF 623-ASP-LEU-624, TISSUE SPECIFICITY.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613; SER-1033 AND SER-1162, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1476 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs."
      Junco S.E., Wang R., Gaipa J.C., Taylor A.B., Schirf V., Gearhart M.D., Bardwell V.J., Demeler B., Hart P.J., Kim C.A.
      Structure 21:665-671(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1634-1748 IN COMPLEX WITH PCGF1, INTERACTION WITH PCGF1, MUTAGENESIS OF LEU-1665.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-832.
    9. Cited for: VARIANT SER-820.

    Entry informationi

    Entry nameiBCORL_HUMAN
    AccessioniPrimary (citable) accession number: Q5H9F3
    Secondary accession number(s): B5MDQ8
    , Q5H9F2, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3