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Protein

Solute carrier family 25 member 53

Gene

SLC25A53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 53
Alternative name(s):
Mitochondrial carrier triple repeat protein 6
Gene namesi
Name:SLC25A53
Synonyms:MCART6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000269743.2.
HGNCiHGNC:31894. SLC25A53.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei181 – 201Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei269 – 290Helical; Name=6Sequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000269743.
PharmGKBiPA142671476.

Polymorphism and mutation databases

BioMutaiSLC25A53.
DMDMi74755435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717911 – 307Solute carrier family 25 member 53Add BLAST307

Proteomic databases

PaxDbiQ5H9E4.
PeptideAtlasiQ5H9E4.
PRIDEiQ5H9E4.

Expressioni

Gene expression databases

BgeeiENSG00000269743.
CleanExiHS_MCART6.
GenevisibleiQ5H9E4. HS.

Organism-specific databases

HPAiHPA034959.

Interactioni

Protein-protein interaction databases

BioGridi135171. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ5H9E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 105Solcar 1Add BLAST81
Repeati112 – 202Solcar 2Add BLAST91
Repeati210 – 302Solcar 3Add BLAST93

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1519. Eukaryota.
ENOG410XNWT. LUCA.
GeneTreeiENSGT00730000110930.
HOGENOMiHOG000233158.
HOVERGENiHBG080244.
InParanoidiQ5H9E4.
OMAiWHSQAYA.
OrthoDBiEOG091G0L68.
PhylomeDBiQ5H9E4.
TreeFamiTF314192.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 2 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5H9E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEQNHSPGK ELQHRTRAEA PGKKSWHSQA YALGAVSNFM STFLTFPIYK
60 70 80 90 100
VVFRQQIHAM AVSEAVRQLW HEGPQYFYRG IYPPLLSKTL QGTLLFGTYD
110 120 130 140 150
SLLCFLSPVG PHTLGHRWAA GLMSGVVEAV ALSPFERVQN VLQDGRKQAR
160 170 180 190 200
FPSTFSILKE FNSYGLWGRL SLGYYRGFWP VLARNSLGSA LYFSFKDPIQ
210 220 230 240 250
DGLAEQGLPH WVPALVSGSV NGTITCLVLY PLIVLVANMQ SHIGWQNMPS
260 270 280 290 300
LWASAQDVWN TRGRKLLLIY RGGSLVILRS SVTWGLTTAI HDFLQRKSHS

RKELKTD
Length:307
Mass (Da):34,481
Last modified:February 15, 2005 - v1
Checksum:i830E366B62DC87AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82254 Genomic DNA. Translation: CAI41997.1.
CH471120 Genomic DNA. Translation: EAX02763.1.
BC140812 mRNA. Translation: AAI40813.1.
BC140814 mRNA. Translation: AAI40815.1.
CCDSiCCDS35363.1.
RefSeqiNP_001012773.2. NM_001012755.4.
XP_005262186.1. XM_005262129.4.
XP_011529254.1. XM_011530952.2.
XP_011529255.1. XM_011530953.2.
XP_016885005.1. XM_017029516.1.
UniGeneiHs.660022.

Genome annotation databases

EnsembliENST00000594199; ENSP00000468980; ENSG00000269743.
GeneIDi401612.
KEGGihsa:401612.
UCSCiuc022cbz.2. human.

Similar proteinsi

Entry informationi

Entry nameiS2553_HUMAN
AccessioniPrimary (citable) accession number: Q5H9E4
Secondary accession number(s): B2RTT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 15, 2005
Last modified: September 27, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families