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Protein

Solute carrier family 25 member 53

Gene

SLC25A53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 53
Alternative name(s):
Mitochondrial carrier triple repeat protein 6
Gene namesi
Name:SLC25A53
Synonyms:MCART6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:31894. SLC25A53.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei181 – 201Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei269 – 290Helical; Name=6Sequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000269743.
PharmGKBiPA142671476.

Polymorphism and mutation databases

BioMutaiSLC25A53.
DMDMi74755435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717911 – 307Solute carrier family 25 member 53Add BLAST307

Proteomic databases

PaxDbiQ5H9E4.
PeptideAtlasiQ5H9E4.
PRIDEiQ5H9E4.

Expressioni

Gene expression databases

BgeeiENSG00000176274.
CleanExiHS_MCART6.
GenevisibleiQ5H9E4. HS.

Organism-specific databases

HPAiHPA034959.

Interactioni

Protein-protein interaction databases

BioGridi135171. 1 interactor.
STRINGi9606.ENSP00000361681.

Structurei

3D structure databases

ProteinModelPortaliQ5H9E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 105Solcar 1Add BLAST81
Repeati112 – 202Solcar 2Add BLAST91
Repeati210 – 302Solcar 3Add BLAST93

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1519. Eukaryota.
ENOG410XNWT. LUCA.
GeneTreeiENSGT00730000110930.
HOGENOMiHOG000233158.
HOVERGENiHBG080244.
InParanoidiQ5H9E4.
OMAiWHSQAYA.
OrthoDBiEOG091G0L68.
PhylomeDBiQ5H9E4.
TreeFamiTF314192.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 2 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5H9E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEQNHSPGK ELQHRTRAEA PGKKSWHSQA YALGAVSNFM STFLTFPIYK
60 70 80 90 100
VVFRQQIHAM AVSEAVRQLW HEGPQYFYRG IYPPLLSKTL QGTLLFGTYD
110 120 130 140 150
SLLCFLSPVG PHTLGHRWAA GLMSGVVEAV ALSPFERVQN VLQDGRKQAR
160 170 180 190 200
FPSTFSILKE FNSYGLWGRL SLGYYRGFWP VLARNSLGSA LYFSFKDPIQ
210 220 230 240 250
DGLAEQGLPH WVPALVSGSV NGTITCLVLY PLIVLVANMQ SHIGWQNMPS
260 270 280 290 300
LWASAQDVWN TRGRKLLLIY RGGSLVILRS SVTWGLTTAI HDFLQRKSHS

RKELKTD
Length:307
Mass (Da):34,481
Last modified:February 15, 2005 - v1
Checksum:i830E366B62DC87AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82254 Genomic DNA. Translation: CAI41997.1.
CH471120 Genomic DNA. Translation: EAX02763.1.
BC140812 mRNA. Translation: AAI40813.1.
BC140814 mRNA. Translation: AAI40815.1.
CCDSiCCDS35363.1.
RefSeqiNP_001012773.2. NM_001012755.4.
XP_005262186.1. XM_005262129.4.
XP_011529254.1. XM_011530952.2.
XP_011529255.1. XM_011530953.2.
XP_016885005.1. XM_017029516.1.
UniGeneiHs.660022.

Genome annotation databases

EnsembliENST00000594199; ENSP00000468980; ENSG00000269743.
GeneIDi401612.
KEGGihsa:401612.
UCSCiuc022cbz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82254 Genomic DNA. Translation: CAI41997.1.
CH471120 Genomic DNA. Translation: EAX02763.1.
BC140812 mRNA. Translation: AAI40813.1.
BC140814 mRNA. Translation: AAI40815.1.
CCDSiCCDS35363.1.
RefSeqiNP_001012773.2. NM_001012755.4.
XP_005262186.1. XM_005262129.4.
XP_011529254.1. XM_011530952.2.
XP_011529255.1. XM_011530953.2.
XP_016885005.1. XM_017029516.1.
UniGeneiHs.660022.

3D structure databases

ProteinModelPortaliQ5H9E4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135171. 1 interactor.
STRINGi9606.ENSP00000361681.

Polymorphism and mutation databases

BioMutaiSLC25A53.
DMDMi74755435.

Proteomic databases

PaxDbiQ5H9E4.
PeptideAtlasiQ5H9E4.
PRIDEiQ5H9E4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000594199; ENSP00000468980; ENSG00000269743.
GeneIDi401612.
KEGGihsa:401612.
UCSCiuc022cbz.2. human.

Organism-specific databases

CTDi401612.
GeneCardsiSLC25A53.
HGNCiHGNC:31894. SLC25A53.
HPAiHPA034959.
MIMi300941. gene.
neXtProtiNX_Q5H9E4.
OpenTargetsiENSG00000269743.
PharmGKBiPA142671476.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1519. Eukaryota.
ENOG410XNWT. LUCA.
GeneTreeiENSGT00730000110930.
HOGENOMiHOG000233158.
HOVERGENiHBG080244.
InParanoidiQ5H9E4.
OMAiWHSQAYA.
OrthoDBiEOG091G0L68.
PhylomeDBiQ5H9E4.
TreeFamiTF314192.

Miscellaneous databases

ChiTaRSiSLC25A53. human.
GenomeRNAii401612.
PROiQ5H9E4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176274.
CleanExiHS_MCART6.
GenevisibleiQ5H9E4. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 2 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2553_HUMAN
AccessioniPrimary (citable) accession number: Q5H9E4
Secondary accession number(s): B2RTT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.