ID   AR13A_HUMAN             Reviewed;         290 AA.
AC   Q5H913; B2RTT6; B4DX50;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   24-JAN-2024, entry version 140.
DE   RecName: Full=ADP-ribosylation factor-like protein 13A;
GN   Name=ARL13A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5H913-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5H913-2; Sequence=VSP_042678;
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; AK301813; BAG63262.1; -; mRNA.
DR   EMBL; Z97985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC140808; AAI40809.1; -; mRNA.
DR   EMBL; BC144603; AAI44604.1; -; mRNA.
DR   CCDS; CCDS55463.1; -. [Q5H913-2]
DR   RefSeq; NP_001155963.1; NM_001162491.1. [Q5H913-2]
DR   AlphaFoldDB; Q5H913; -.
DR   SMR; Q5H913; -.
DR   BioGRID; 134249; 14.
DR   IntAct; Q5H913; 2.
DR   STRING; 9606.ENSP00000398637; -.
DR   iPTMnet; Q5H913; -.
DR   PhosphoSitePlus; Q5H913; -.
DR   BioMuta; ARL13A; -.
DR   DMDM; 308153411; -.
DR   jPOST; Q5H913; -.
DR   MassIVE; Q5H913; -.
DR   PaxDb; 9606-ENSP00000398637; -.
DR   PeptideAtlas; Q5H913; -.
DR   ProteomicsDB; 62860; -. [Q5H913-1]
DR   ProteomicsDB; 62861; -. [Q5H913-2]
DR   Antibodypedia; 51206; 36 antibodies from 10 providers.
DR   DNASU; 392509; -.
DR   Ensembl; ENST00000450049.7; ENSP00000398637.2; ENSG00000174225.15. [Q5H913-2]
DR   Ensembl; ENST00000450457.6; ENSP00000414757.2; ENSG00000174225.15. [Q5H913-1]
DR   GeneID; 392509; -.
DR   KEGG; hsa:392509; -.
DR   MANE-Select; ENST00000450049.7; ENSP00000398637.2; NM_001162491.2; NP_001155963.1. [Q5H913-2]
DR   UCSC; uc010nng.4; human. [Q5H913-1]
DR   AGR; HGNC:31709; -.
DR   CTD; 392509; -.
DR   DisGeNET; 392509; -.
DR   GeneCards; ARL13A; -.
DR   HGNC; HGNC:31709; ARL13A.
DR   HPA; ENSG00000174225; Tissue enriched (testis).
DR   neXtProt; NX_Q5H913; -.
DR   OpenTargets; ENSG00000174225; -.
DR   PharmGKB; PA134890660; -.
DR   VEuPathDB; HostDB:ENSG00000174225; -.
DR   eggNOG; KOG0073; Eukaryota.
DR   GeneTree; ENSGT00940000161284; -.
DR   HOGENOM; CLU_040729_3_1_1; -.
DR   InParanoid; Q5H913; -.
DR   OMA; DRRNHQP; -.
DR   OrthoDB; 5483033at2759; -.
DR   PhylomeDB; Q5H913; -.
DR   TreeFam; TF105476; -.
DR   PathwayCommons; Q5H913; -.
DR   SignaLink; Q5H913; -.
DR   BioGRID-ORCS; 392509; 16 hits in 765 CRISPR screens.
DR   GenomeRNAi; 392509; -.
DR   Pharos; Q5H913; Tdark.
DR   PRO; PR:Q5H913; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q5H913; Protein.
DR   Bgee; ENSG00000174225; Expressed in primordial germ cell in gonad and 98 other cell types or tissues.
DR   ExpressionAtlas; Q5H913; baseline and differential.
DR   GO; GO:0060170; C:ciliary membrane; IBA:GO_Central.
DR   GO; GO:0097730; C:non-motile cilium; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR   GO; GO:0097500; P:receptor localization to non-motile cilium; IBA:GO_Central.
DR   CDD; cd04161; Arl2l1_Arl13_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR46090:SF1; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13A; 1.
DR   PANTHER; PTHR46090; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00177; ARF; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..290
FT                   /note="ADP-ribosylation factor-like protein 13A"
FT                   /id="PRO_0000284145"
FT   REGION          204..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..222
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         28..35
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         71..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         130..133
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         249..290
FT                   /note="KEGTRLWSKKNMSVTFALDEPMKEGECSRRMRAQNTTKLCYN -> PSNQSY
FT                   TH (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_042678"
SQ   SEQUENCE   290 AA;  33003 MW;  56ADA388F7BE747A CRC64;
     MFRLLSSCCS CLRTTEETRR NVTIPIIGLN NSGKTVLVEA FQKLLPSKTD HCMKSELTTL
     LLDEYELSIY DLNGDLKGRE AWPNYYAQAH GLVFVLDSSD IRRMQEVKII LTHLLSDKRV
     AGKPILILAN KQDKKKALMP CDIIDYLLLK KLVKENKCPC RVEPCSAIRN LERRNHQPIV
     EGLRWLLAVI DTCQLPPTSS ISISKNNTGS GERCSSHSFS TRTGMSKEKR QHLEQCSIEA
     KPLKSILQKE GTRLWSKKNM SVTFALDEPM KEGECSRRMR AQNTTKLCYN
//