ID   NMS_HUMAN               Reviewed;         153 AA.
AC   Q5H8A3;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   24-JAN-2024, entry version 118.
DE   RecName: Full=Neuromedin-S;
DE   Flags: Precursor;
GN   Name=NMS;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=15635449; DOI=10.1038/sj.emboj.7600526;
RA   Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M.,
RA   Kangawa K.;
RT   "Identification of neuromedin S and its possible role in the mammalian
RT   circadian oscillator system.";
RL   EMBO J. 24:325-335(2005).
CC   -!- FUNCTION: Implicated in the regulation of circadian rhythms through
CC       autocrine and/or paracrine actions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
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DR   EMBL; AB164464; BAD89024.1; -; mRNA.
DR   CCDS; CCDS33259.1; -.
DR   RefSeq; NP_001011717.1; NM_001011717.1.
DR   PDB; 7W56; EM; 2.90 A; C=109-141.
DR   PDB; 7W57; EM; 3.20 A; C=109-141.
DR   PDBsum; 7W56; -.
DR   PDBsum; 7W57; -.
DR   AlphaFoldDB; Q5H8A3; -.
DR   EMDB; EMD-32315; -.
DR   EMDB; EMD-32316; -.
DR   SMR; Q5H8A3; -.
DR   BioGRID; 126194; 40.
DR   STRING; 9606.ENSP00000366061; -.
DR   BioMuta; NMS; -.
DR   DMDM; 74722605; -.
DR   PaxDb; 9606-ENSP00000366061; -.
DR   TopDownProteomics; Q5H8A3; -.
DR   Antibodypedia; 48800; 141 antibodies from 21 providers.
DR   DNASU; 129521; -.
DR   Ensembl; ENST00000376865.1; ENSP00000366061.1; ENSG00000204640.1.
DR   GeneID; 129521; -.
DR   KEGG; hsa:129521; -.
DR   MANE-Select; ENST00000376865.1; ENSP00000366061.1; NM_001011717.1; NP_001011717.1.
DR   UCSC; uc002tan.1; human.
DR   AGR; HGNC:32203; -.
DR   CTD; 129521; -.
DR   DisGeNET; 129521; -.
DR   GeneCards; NMS; -.
DR   HGNC; HGNC:32203; NMS.
DR   HPA; ENSG00000204640; Not detected.
DR   MIM; 619337; gene.
DR   neXtProt; NX_Q5H8A3; -.
DR   OpenTargets; ENSG00000204640; -.
DR   PharmGKB; PA142671260; -.
DR   VEuPathDB; HostDB:ENSG00000204640; -.
DR   eggNOG; ENOG502SB16; Eukaryota.
DR   GeneTree; ENSGT00510000049213; -.
DR   HOGENOM; CLU_090356_1_0_1; -.
DR   InParanoid; Q5H8A3; -.
DR   OMA; CMLPIPS; -.
DR   OrthoDB; 5305257at2759; -.
DR   PhylomeDB; Q5H8A3; -.
DR   TreeFam; TF338319; -.
DR   PathwayCommons; Q5H8A3; -.
DR   Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   SignaLink; Q5H8A3; -.
DR   SIGNOR; Q5H8A3; -.
DR   BioGRID-ORCS; 129521; 11 hits in 1133 CRISPR screens.
DR   GenomeRNAi; 129521; -.
DR   Pharos; Q5H8A3; Tbio.
DR   PRO; PR:Q5H8A3; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q5H8A3; Protein.
DR   Bgee; ENSG00000204640; Expressed in hypothalamus and 19 other cell types or tissues.
DR   ExpressionAtlas; Q5H8A3; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR   GO; GO:0045475; P:locomotor rhythm; IEA:Ensembl.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR018070; Neuromedin-U_amidation-site.
DR   InterPro; IPR043253; NmS.
DR   PANTHER; PTHR32414; NEUROMEDIN-S; 1.
DR   PANTHER; PTHR32414:SF2; NEUROMEDIN-S; 1.
DR   PROSITE; PS00967; NMU; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..69
FT                   /id="PRO_0000262480"
FT   PROPEP          70..105
FT                   /id="PRO_0000262481"
FT   PROPEP          106..108
FT                   /id="PRO_0000262482"
FT   PEPTIDE         109..141
FT                   /note="Neuromedin-S"
FT                   /id="PRO_0000262483"
FT   PROPEP          144..153
FT                   /id="PRO_0000262484"
FT   MOD_RES         141
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250"
FT   VARIANT         6
FT                   /note="P -> S (in dbSNP:rs13411940)"
FT                   /id="VAR_029495"
SQ   SEQUENCE   153 AA;  17731 MW;  93B65FB17876C600 CRC64;
     MKHLRPQFPL ILAIYCFCML QIPSSGFPQP LADPSDGLDI VQLEQLAYCL SQWAPLSRQP
     KDNQDIYKRF LFHYSRTQEA THPVKTGFPP VHPLMHLAAK LANRRMKRIL QRGSGTAAVD
     FTKKDHTATW GRPFFLFRPR NGRNIEDEAQ IQW
//