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Q5H8A3 (NMS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuromedin-S
Gene names
Name:NMS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the NmU family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionNeuropeptide
   PTMAmidation
Cleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Propeptide27 – 6943
PRO_0000262480
Propeptide70 – 10536
PRO_0000262481
Propeptide106 – 1083
PRO_0000262482
Peptide109 – 14133Neuromedin-S
PRO_0000262483
Propeptide144 – 15310
PRO_0000262484

Amino acid modifications

Modified residue1411Asparagine amide By similarity

Natural variations

Natural variant61P → S.
Corresponds to variant rs13411940 [ dbSNP | Ensembl ].
VAR_029495

Sequences

Sequence LengthMass (Da)Tools
Q5H8A3 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 93B65FB17876C600

FASTA15317,731
        10         20         30         40         50         60 
MKHLRPQFPL ILAIYCFCML QIPSSGFPQP LADPSDGLDI VQLEQLAYCL SQWAPLSRQP 

        70         80         90        100        110        120 
KDNQDIYKRF LFHYSRTQEA THPVKTGFPP VHPLMHLAAK LANRRMKRIL QRGSGTAAVD 

       130        140        150 
FTKKDHTATW GRPFFLFRPR NGRNIEDEAQ IQW 

« Hide

References

[1]"Identification of neuromedin S and its possible role in the mammalian circadian oscillator system."
Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M., Kangawa K.
EMBO J. 24:325-335(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB164464 mRNA. Translation: BAD89024.1.
CCDSCCDS33259.1.
RefSeqNP_001011717.1. NM_001011717.1.
UniGeneHs.567676.

3D structure databases

ProteinModelPortalQ5H8A3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000366061.

Polymorphism databases

DMDM74722605.

Proteomic databases

PaxDbQ5H8A3.
PRIDEQ5H8A3.

Protocols and materials databases

DNASU129521.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376865; ENSP00000366061; ENSG00000204640.
GeneID129521.
KEGGhsa:129521.
UCSCuc002tan.1. human.

Organism-specific databases

CTD129521.
GeneCardsGC02P101086.
HGNCHGNC:32203. NMS.
HPAHPA035420.
neXtProtNX_Q5H8A3.
PharmGKBPA142671260.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG122013.
HOGENOMHOG000060184.
HOVERGENHBG082033.
InParanoidQ5H8A3.
OMASILAIYC.
OrthoDBEOG7FZ00S.
PhylomeDBQ5H8A3.
TreeFamTF338319.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_NMS.
GenevestigatorQ5H8A3.

Family and domain databases

InterProIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEPS00967. NMU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi129521.
NextBio82591.
PROQ5H8A3.

Entry information

Entry nameNMS_HUMAN
AccessionPrimary (citable) accession number: Q5H8A3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM