Q5H8A3 (NMS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuromedin-S

Gene names

Name:

NMS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the NmU family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Neuropeptide
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW regulation of smooth muscle contraction Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Propeptide	27 – 69	43			PRO_0000262480
	Propeptide	70 – 105	36			PRO_0000262481
	Propeptide	106 – 108	3			PRO_0000262482
	Peptide	109 – 141	33	Neuromedin-S		PRO_0000262483
	Propeptide	144 – 153	10			PRO_0000262484
Amino acid modifications
	Modified residue	141	1	Asparagine amide By similarity
Natural variations
	Natural variant	6	1	P → S. Corresponds to variant rs13411940 [ dbSNP | Ensembl ].		VAR_029495

Sequences

	Sequence		Length	Mass (Da)
	Q5H8A3 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 93B65FB17876C600	FASTA	153	17,731
	10 20 30 40 50 60 MKHLRPQFPL ILAIYCFCML QIPSSGFPQP LADPSDGLDI VQLEQLAYCL SQWAPLSRQP 70 80 90 100 110 120 KDNQDIYKRF LFHYSRTQEA THPVKTGFPP VHPLMHLAAK LANRRMKRIL QRGSGTAAVD 130 140 150 FTKKDHTATW GRPFFLFRPR NGRNIEDEAQ IQW

References

[1]	"Identification of neuromedin S and its possible role in the mammalian circadian oscillator system." Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M., Kangawa K. EMBO J. 24:325-335(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB164464 mRNA. Translation: BAD89024.1.
IPI	IPI00552964.
RefSeq	NP_001011717.1. NM_001011717.1.
UniGene	Hs.567676.
3D structure databases
ProteinModelPortal	Q5H8A3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000366061.
Polymorphism databases
DMDM	74722605.
Proteomic databases
PaxDb	Q5H8A3.
PRIDE	Q5H8A3.
Protocols and materials databases
DNASU	129521.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376865; ENSP00000366061; ENSG00000204640.
GeneID	129521.
KEGG	hsa:129521.
UCSC	uc002tan.1. human.
Organism-specific databases
CTD	129521.
GeneCards	GC02P101086.
HGNC	HGNC:32203. NMS.
HPA	HPA035420.
neXtProt	NX_Q5H8A3.
PharmGKB	PA142671260.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG122013.
HOGENOM	HOG000060184.
HOVERGEN	HBG082033.
InParanoid	Q5H8A3.
OMA	SILAIYC.
OrthoDB	EOG4J6RS2.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_NMS.
Genevestigator	Q5H8A3.
Family and domain databases
InterPro	IPR018070. Neuromedin-U_amidation-site. IPR008200. NMU_C. [Graphical view]
Pfam	PF02070. NMU. 1 hit. [Graphical view]
PROSITE	PS00967. NMU. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	129521.
NextBio	82591.

Entry information

Entry name

NMS_HUMAN

Accession

Primary (citable) accession number: Q5H8A3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	March 1, 2005
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.