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Q5H8A3

- NMS_HUMAN

UniProt

Q5H8A3 - NMS_HUMAN

Protein

Neuromedin-S

Gene

NMS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.By similarity

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuromedin-S
    Gene namesi
    Name:NMS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:32203. NMS.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671260.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Propeptidei27 – 6943PRO_0000262480Add
    BLAST
    Propeptidei70 – 10536PRO_0000262481Add
    BLAST
    Propeptidei106 – 1083PRO_0000262482
    Peptidei109 – 14133Neuromedin-SPRO_0000262483Add
    BLAST
    Propeptidei144 – 15310PRO_0000262484

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei141 – 1411Asparagine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiQ5H8A3.
    PRIDEiQ5H8A3.

    Expressioni

    Gene expression databases

    CleanExiHS_NMS.
    GenevestigatoriQ5H8A3.

    Organism-specific databases

    HPAiHPA035420.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000366061.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5H8A3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NmU family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG122013.
    HOGENOMiHOG000060184.
    HOVERGENiHBG082033.
    InParanoidiQ5H8A3.
    OMAiSILAIYC.
    OrthoDBiEOG7FZ00S.
    PhylomeDBiQ5H8A3.
    TreeFamiTF338319.

    Family and domain databases

    InterProiIPR018070. Neuromedin-U_amidation-site.
    [Graphical view]
    PROSITEiPS00967. NMU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5H8A3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKHLRPQFPL ILAIYCFCML QIPSSGFPQP LADPSDGLDI VQLEQLAYCL    50
    SQWAPLSRQP KDNQDIYKRF LFHYSRTQEA THPVKTGFPP VHPLMHLAAK 100
    LANRRMKRIL QRGSGTAAVD FTKKDHTATW GRPFFLFRPR NGRNIEDEAQ 150
    IQW 153
    Length:153
    Mass (Da):17,731
    Last modified:March 1, 2005 - v1
    Checksum:i93B65FB17876C600
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61P → S.
    Corresponds to variant rs13411940 [ dbSNP | Ensembl ].
    VAR_029495

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB164464 mRNA. Translation: BAD89024.1.
    CCDSiCCDS33259.1.
    RefSeqiNP_001011717.1. NM_001011717.1.
    UniGeneiHs.567676.

    Genome annotation databases

    EnsembliENST00000376865; ENSP00000366061; ENSG00000204640.
    GeneIDi129521.
    KEGGihsa:129521.
    UCSCiuc002tan.1. human.

    Polymorphism databases

    DMDMi74722605.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB164464 mRNA. Translation: BAD89024.1 .
    CCDSi CCDS33259.1.
    RefSeqi NP_001011717.1. NM_001011717.1.
    UniGenei Hs.567676.

    3D structure databases

    ProteinModelPortali Q5H8A3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000366061.

    Polymorphism databases

    DMDMi 74722605.

    Proteomic databases

    PaxDbi Q5H8A3.
    PRIDEi Q5H8A3.

    Protocols and materials databases

    DNASUi 129521.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376865 ; ENSP00000366061 ; ENSG00000204640 .
    GeneIDi 129521.
    KEGGi hsa:129521.
    UCSCi uc002tan.1. human.

    Organism-specific databases

    CTDi 129521.
    GeneCardsi GC02P101086.
    HGNCi HGNC:32203. NMS.
    HPAi HPA035420.
    neXtProti NX_Q5H8A3.
    PharmGKBi PA142671260.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG122013.
    HOGENOMi HOG000060184.
    HOVERGENi HBG082033.
    InParanoidi Q5H8A3.
    OMAi SILAIYC.
    OrthoDBi EOG7FZ00S.
    PhylomeDBi Q5H8A3.
    TreeFami TF338319.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 129521.
    NextBioi 82591.
    PROi Q5H8A3.

    Gene expression databases

    CleanExi HS_NMS.
    Genevestigatori Q5H8A3.

    Family and domain databases

    InterProi IPR018070. Neuromedin-U_amidation-site.
    [Graphical view ]
    PROSITEi PS00967. NMU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system."
      Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M., Kangawa K.
      EMBO J. 24:325-335(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNMS_HUMAN
    AccessioniPrimary (citable) accession number: Q5H8A3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3