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Protein

Neuromedin-S

Gene

NMS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.By similarity

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-S
Gene namesi
Name:NMS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:32203. NMS.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Propeptidei27 – 6943PRO_0000262480Add
BLAST
Propeptidei70 – 10536PRO_0000262481Add
BLAST
Propeptidei106 – 1083PRO_0000262482
Peptidei109 – 14133Neuromedin-SPRO_0000262483Add
BLAST
Propeptidei144 – 15310PRO_0000262484

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei141 – 1411Asparagine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ5H8A3.
PRIDEiQ5H8A3.

Expressioni

Gene expression databases

CleanExiHS_NMS.
GenevestigatoriQ5H8A3.

Organism-specific databases

HPAiHPA035420.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366061.

Structurei

3D structure databases

ProteinModelPortaliQ5H8A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG122013.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ5H8A3.
OMAiSILAIYC.
OrthoDBiEOG7FZ00S.
PhylomeDBiQ5H8A3.
TreeFamiTF338319.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5H8A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLRPQFPL ILAIYCFCML QIPSSGFPQP LADPSDGLDI VQLEQLAYCL
60 70 80 90 100
SQWAPLSRQP KDNQDIYKRF LFHYSRTQEA THPVKTGFPP VHPLMHLAAK
110 120 130 140 150
LANRRMKRIL QRGSGTAAVD FTKKDHTATW GRPFFLFRPR NGRNIEDEAQ

IQW
Length:153
Mass (Da):17,731
Last modified:March 1, 2005 - v1
Checksum:i93B65FB17876C600
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61P → S.
Corresponds to variant rs13411940 [ dbSNP | Ensembl ].
VAR_029495

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164464 mRNA. Translation: BAD89024.1.
CCDSiCCDS33259.1.
RefSeqiNP_001011717.1. NM_001011717.1.
UniGeneiHs.567676.

Genome annotation databases

EnsembliENST00000376865; ENSP00000366061; ENSG00000204640.
GeneIDi129521.
KEGGihsa:129521.
UCSCiuc002tan.1. human.

Polymorphism databases

DMDMi74722605.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164464 mRNA. Translation: BAD89024.1.
CCDSiCCDS33259.1.
RefSeqiNP_001011717.1. NM_001011717.1.
UniGeneiHs.567676.

3D structure databases

ProteinModelPortaliQ5H8A3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366061.

Polymorphism databases

DMDMi74722605.

Proteomic databases

PaxDbiQ5H8A3.
PRIDEiQ5H8A3.

Protocols and materials databases

DNASUi129521.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376865; ENSP00000366061; ENSG00000204640.
GeneIDi129521.
KEGGihsa:129521.
UCSCiuc002tan.1. human.

Organism-specific databases

CTDi129521.
GeneCardsiGC02P101086.
HGNCiHGNC:32203. NMS.
HPAiHPA035420.
neXtProtiNX_Q5H8A3.
PharmGKBiPA142671260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG122013.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ5H8A3.
OMAiSILAIYC.
OrthoDBiEOG7FZ00S.
PhylomeDBiQ5H8A3.
TreeFamiTF338319.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii129521.
NextBioi82591.
PROiQ5H8A3.

Gene expression databases

CleanExiHS_NMS.
GenevestigatoriQ5H8A3.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system."
    Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M., Kangawa K.
    EMBO J. 24:325-335(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNMS_HUMAN
AccessioniPrimary (citable) accession number: Q5H8A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2005
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.