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Protein

Neuromedin-S

Gene

NMS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

BioCyciZFISH:G66-31571-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiQ5H8A3.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-S
Gene namesi
Name:NMS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:32203. NMS.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi129521.
OpenTargetsiENSG00000204640.
PharmGKBiPA142671260.

Polymorphism and mutation databases

BioMutaiNMS.
DMDMi74722605.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000026248027 – 69Add BLAST43
PropeptideiPRO_000026248170 – 105Add BLAST36
PropeptideiPRO_0000262482106 – 1083
PeptideiPRO_0000262483109 – 141Neuromedin-SAdd BLAST33
PropeptideiPRO_0000262484144 – 15310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141Asparagine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ5H8A3.
PRIDEiQ5H8A3.

Expressioni

Gene expression databases

CleanExiHS_NMS.

Organism-specific databases

HPAiHPA035420.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366061.

Structurei

3D structure databases

ProteinModelPortaliQ5H8A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX42. Eukaryota.
ENOG4111CPK. LUCA.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ5H8A3.
OMAiNRRMKRF.
OrthoDBiEOG091G0YD0.
PhylomeDBiQ5H8A3.
TreeFamiTF338319.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5H8A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLRPQFPL ILAIYCFCML QIPSSGFPQP LADPSDGLDI VQLEQLAYCL
60 70 80 90 100
SQWAPLSRQP KDNQDIYKRF LFHYSRTQEA THPVKTGFPP VHPLMHLAAK
110 120 130 140 150
LANRRMKRIL QRGSGTAAVD FTKKDHTATW GRPFFLFRPR NGRNIEDEAQ

IQW
Length:153
Mass (Da):17,731
Last modified:March 1, 2005 - v1
Checksum:i93B65FB17876C600
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0294956P → S.Corresponds to variant rs13411940dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164464 mRNA. Translation: BAD89024.1.
CCDSiCCDS33259.1.
RefSeqiNP_001011717.1. NM_001011717.1.
UniGeneiHs.567676.

Genome annotation databases

EnsembliENST00000376865; ENSP00000366061; ENSG00000204640.
GeneIDi129521.
KEGGihsa:129521.
UCSCiuc002tan.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164464 mRNA. Translation: BAD89024.1.
CCDSiCCDS33259.1.
RefSeqiNP_001011717.1. NM_001011717.1.
UniGeneiHs.567676.

3D structure databases

ProteinModelPortaliQ5H8A3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366061.

Polymorphism and mutation databases

BioMutaiNMS.
DMDMi74722605.

Proteomic databases

PaxDbiQ5H8A3.
PRIDEiQ5H8A3.

Protocols and materials databases

DNASUi129521.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376865; ENSP00000366061; ENSG00000204640.
GeneIDi129521.
KEGGihsa:129521.
UCSCiuc002tan.1. human.

Organism-specific databases

CTDi129521.
DisGeNETi129521.
GeneCardsiNMS.
HGNCiHGNC:32203. NMS.
HPAiHPA035420.
neXtProtiNX_Q5H8A3.
OpenTargetsiENSG00000204640.
PharmGKBiPA142671260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX42. Eukaryota.
ENOG4111CPK. LUCA.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ5H8A3.
OMAiNRRMKRF.
OrthoDBiEOG091G0YD0.
PhylomeDBiQ5H8A3.
TreeFamiTF338319.

Enzyme and pathway databases

BioCyciZFISH:G66-31571-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiQ5H8A3.

Miscellaneous databases

GenomeRNAii129521.
PROiQ5H8A3.

Gene expression databases

CleanExiHS_NMS.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMS_HUMAN
AccessioniPrimary (citable) accession number: Q5H8A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.