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Protein

Neuromedin-S

Gene

Nms

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. Stimulates the contraction of rectum and elevation of blood pressure.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI

GO - Biological processi

  • locomotor rhythm Source: MGI
  • neuropeptide signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-S
Gene namesi
Name:Nms
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1359122. NMS.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Propeptidei27 – 6943PRO_0000262490Add
BLAST
Propeptidei70 – 10536PRO_0000262491Add
BLAST
Propeptidei106 – 10831 PublicationPRO_0000262492
Peptidei109 – 14436Neuromedin-SPRO_0000262493Add
BLAST
Propeptidei147 – 1526PRO_0000262494

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei144 – 1441Asparagine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ5H8A2.

Expressioni

Tissue specificityi

Expressed in the CNS, spleen and testis. Specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus.1 Publication

Inductioni

Expression has a diurnal peak under light/dark cycling, but remains stable under constant darkness.1 Publication

Gene expression databases

ExpressionAtlasiQ5H8A2. baseline and differential.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056345.

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX42. Eukaryota.
ENOG4111CPK. LUCA.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ5H8A2.
OMAiNRRMKRF.
OrthoDBiEOG091G0YD0.
PhylomeDBiQ5H8A2.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5H8A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHPFPQFPP ILVIYCFCML QIPSSGASPP LAGPPDGLDA VDPERLAHFL
60 70 80 90 100
NQRETCSNQP KESRDVYKRF LFHYSRAWKS THPVNSEFAP VHPLMRLAAK
110 120 130 140 150
LPSRRMKRLP RLLHTDSRMA TIDFPKKDPT TSLGRPFFLF RPRNGRYTDK

VQ
Length:152
Mass (Da):17,572
Last modified:March 1, 2005 - v1
Checksum:iF60C68007C5D7314
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164465 mRNA. Translation: BAD89025.1.
RefSeqiNP_001012233.1. NM_001012233.1.
UniGeneiRn.137581.

Genome annotation databases

EnsembliENSRNOT00000059587; ENSRNOP00000056345; ENSRNOG00000038979.
GeneIDi497196.
KEGGirno:497196.
UCSCiRGD:1359122. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164465 mRNA. Translation: BAD89025.1.
RefSeqiNP_001012233.1. NM_001012233.1.
UniGeneiRn.137581.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056345.

Proteomic databases

PaxDbiQ5H8A2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000059587; ENSRNOP00000056345; ENSRNOG00000038979.
GeneIDi497196.
KEGGirno:497196.
UCSCiRGD:1359122. rat.

Organism-specific databases

CTDi129521.
RGDi1359122. NMS.

Phylogenomic databases

eggNOGiENOG410IX42. Eukaryota.
ENOG4111CPK. LUCA.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ5H8A2.
OMAiNRRMKRF.
OrthoDBiEOG091G0YD0.
PhylomeDBiQ5H8A2.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ5H8A2.

Gene expression databases

ExpressionAtlasiQ5H8A2. baseline and differential.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMS_RAT
AccessioniPrimary (citable) accession number: Q5H8A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.