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Protein

Neuromedin-S

Gene

Nms

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. Stimulates the contraction of rectum and elevation of blood pressure.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI

GO - Biological processi

  • locomotor rhythm Source: MGI
  • neuropeptide signaling pathway Source: MGI

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-S
Gene namesi
Name:Nms
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1359122. NMS.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000026249027 – 69Add BLAST43
PropeptideiPRO_000026249170 – 105Add BLAST36
PropeptideiPRO_0000262492106 – 1081 Publication3
PeptideiPRO_0000262493109 – 144Neuromedin-SAdd BLAST36
PropeptideiPRO_0000262494147 – 1526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei144Asparagine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ5H8A2.
PRIDEiQ5H8A2.

Expressioni

Tissue specificityi

Expressed in the CNS, spleen and testis. Specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus.1 Publication

Inductioni

Expression has a diurnal peak under light/dark cycling, but remains stable under constant darkness.1 Publication

Gene expression databases

BgeeiENSRNOG00000038979.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056345.

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX42. Eukaryota.
ENOG4111CPK. LUCA.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ5H8A2.
OMAiPRNGRNT.
OrthoDBiEOG091G0YD0.
PhylomeDBiQ5H8A2.

Family and domain databases

InterProiView protein in InterPro
IPR018070. Neuromedin-U_amidation-site.
PROSITEiView protein in PROSITE
PS00967. NMU. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5H8A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHPFPQFPP ILVIYCFCML QIPSSGASPP LAGPPDGLDA VDPERLAHFL
60 70 80 90 100
NQRETCSNQP KESRDVYKRF LFHYSRAWKS THPVNSEFAP VHPLMRLAAK
110 120 130 140 150
LPSRRMKRLP RLLHTDSRMA TIDFPKKDPT TSLGRPFFLF RPRNGRYTDK

VQ
Length:152
Mass (Da):17,572
Last modified:March 1, 2005 - v1
Checksum:iF60C68007C5D7314
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164465 mRNA. Translation: BAD89025.1.
RefSeqiNP_001012233.1. NM_001012233.1.
UniGeneiRn.137581.

Genome annotation databases

EnsembliENSRNOT00000059587; ENSRNOP00000056345; ENSRNOG00000038979.
GeneIDi497196.
KEGGirno:497196.
UCSCiRGD:1359122. rat.

Similar proteinsi

Entry informationi

Entry nameiNMS_RAT
AccessioniPrimary (citable) accession number: Q5H8A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2005
Last modified: August 30, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families