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Protein

Neuromedin-S

Gene

Nms

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-S
Gene namesi
Name:Nms
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3583618. Nms.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Propeptidei27 – 6943PRO_0000262485Add
BLAST
Propeptidei70 – 10536PRO_0000262486Add
BLAST
Propeptidei106 – 1083PRO_0000262487
Peptidei109 – 14436Neuromedin-SPRO_0000262488Add
BLAST
Propeptidei147 – 1537PRO_0000262489

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei144 – 1441Asparagine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ5H8A1.
PRIDEiQ5H8A1.

Expressioni

Gene expression databases

BgeeiQ5H8A1.
CleanExiMM_NMS.
ExpressionAtlasiQ5H8A1. differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085346.

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX42. Eukaryota.
ENOG4111CPK. LUCA.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ5H8A1.
OMAiSILAIYC.
OrthoDBiEOG7FZ00S.
PhylomeDBiQ5H8A1.
TreeFamiTF338319.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5H8A1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHPLPHYSP ILFIYCFCML QIPSSGASPP LADSPDGLDI VDPERLAYFL
60 70 80 90 100
KQREIHSNQP KENQDVYKRF LFHYSRTRKP THPVSAEFAP VHPLMRLAAK
110 120 130 140 150
LASRRMKRLP RLLRLDSRMA TVDFPKKDPT TSLGRPFFLF RPRNGRYTDN

NFQ
Length:153
Mass (Da):17,883
Last modified:March 1, 2005 - v1
Checksum:iB54932C24D2A4507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164466 mRNA. Translation: BAD89026.1.
BC138922 mRNA. Translation: AAI38923.1.
CCDSiCCDS14902.1.
RefSeqiNP_001011684.3. NM_001011684.2.
UniGeneiMm.333709.

Genome annotation databases

EnsembliENSMUST00000088029; ENSMUSP00000085346; ENSMUSG00000067604.
GeneIDi433292.
KEGGimmu:433292.
UCSCiuc007atb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164466 mRNA. Translation: BAD89026.1.
BC138922 mRNA. Translation: AAI38923.1.
CCDSiCCDS14902.1.
RefSeqiNP_001011684.3. NM_001011684.2.
UniGeneiMm.333709.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085346.

Proteomic databases

PaxDbiQ5H8A1.
PRIDEiQ5H8A1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088029; ENSMUSP00000085346; ENSMUSG00000067604.
GeneIDi433292.
KEGGimmu:433292.
UCSCiuc007atb.1. mouse.

Organism-specific databases

CTDi129521.
MGIiMGI:3583618. Nms.

Phylogenomic databases

eggNOGiENOG410IX42. Eukaryota.
ENOG4111CPK. LUCA.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ5H8A1.
OMAiSILAIYC.
OrthoDBiEOG7FZ00S.
PhylomeDBiQ5H8A1.
TreeFamiTF338319.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi408552.
PROiQ5H8A1.
SOURCEiSearch...

Gene expression databases

BgeeiQ5H8A1.
CleanExiMM_NMS.
ExpressionAtlasiQ5H8A1. differential.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system."
    Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M., Kangawa K.
    EMBO J. 24:325-335(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNMS_MOUSE
AccessioniPrimary (citable) accession number: Q5H8A1
Secondary accession number(s): B2RSM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2005
Last modified: February 17, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.