ID   Q5H728_MACMU            Unreviewed;       247 AA.
AC   Q5H728;
DT   01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2005, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=trypsin {ECO:0000256|ARBA:ARBA00038868};
DE            EC=3.4.21.4 {ECO:0000256|ARBA:ARBA00038868};
GN   Name=try16 {ECO:0000313|EMBL:AAW69367.1};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|EMBL:AAW69367.1};
RN   [1] {ECO:0000313|EMBL:AAW69367.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Rowen L., Geraghty D., Daza R., Bloom S., Hood L.;
RT   "Sequence of the beta T-cell receptor locus from rhesus macaque.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00036320};
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DR   EMBL; AC149201; AAW69367.1; -; Genomic_DNA.
DR   RefSeq; NP_001040585.1; NM_001047120.1.
DR   RefSeq; XP_014990580.1; XM_015135094.1.
DR   AlphaFoldDB; Q5H728; -.
DR   MEROPS; S01.258; -.
DR   GeneID; 698352; -.
DR   KEGG; mcc:698352; -.
DR   CTD; 5645; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   OrthoDB; 4629979at2759; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24264:SF57; TRYPSIN-2; 1.
DR   PANTHER; PTHR24264; TRYPSIN-RELATED; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU363034};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW   ECO:0000256|RuleBase:RU363034}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..247
FT                   /note="trypsin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015097894"
FT   DOMAIN          24..244
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   247 AA;  26496 MW;  9688EFEA21439F0D CRC64;
     MNPLLILAFV GVAVAAPFDD DDKIVGGYTC EENSVPYQVS LNSGYHFCGG SLINEQWVVS
     AAHCYKTRIQ VRLGEHNIEV LEGTEQFINA AKIIRHPDYD RKTLNNDILL IKLSSPAVIN
     ARVSTISLPT APPAAGAEAL ISGWGNTLSS GADYPDELQC LEAPVLSQAE CEASYPGKIT
     SNMFCVGFLE GGKDSCQGDS GGPVVSNGQL QGIVSWGYGC AQKNRPGVYT KVYNYVDWIR
     DTIAANS
//