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Q5H6Z4

- LLDD_XANOR

UniProt

Q5H6Z4 - LLDD_XANOR

Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

    Catalytic activityi

    (S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

    Cofactori

    FMN.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei24 – 241SubstrateUniRule annotation
    Binding sitei106 – 1061FMNUniRule annotation
    Binding sitei127 – 1271FMNUniRule annotation
    Binding sitei129 – 1291SubstrateUniRule annotation
    Binding sitei155 – 1551FMNUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Binding sitei251 – 2511FMNUniRule annotation
    Active sitei275 – 2751Proton acceptorUniRule annotation
    Binding sitei278 – 2781SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi306 – 33025FMNUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. L-lactate dehydrogenase (cytochrome) activity Source: InterPro

    GO - Biological processi

    1. lactate oxidation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    BioCyciXORY291331:GJBV-20-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
    Gene namesi
    Name:lldDUniRule annotation
    Ordered Locus Names:XOO0022
    OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
    Taxonomic identifieri291331 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000006735: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388L-lactate dehydrogenasePRO_0000206358Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi291331.XOO0022.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5H6Z4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 380380FMN hydroxy acid dehydrogenaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation
    Contains 1 FMN hydroxy acid dehydrogenase domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1304.
    KOiK00101.
    OMAiPWFQLYM.
    OrthoDBiEOG6HMXBG.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01559. L_lact_dehydr.
    InterProiIPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    IPR020920. L-lactate_DHase_bac.
    [Graphical view]
    PfamiPF01070. FMN_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5H6Z4-1 [UniParc]FASTAAdd to Basket

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    MIISAASDYR AAAQARLPPF LFHYIDGGAY AEHTLRRNVS DLADVALRQR    50
    VLRNMSDLRL STELFGETLA MPVALGPVGL TGMYARRGEV QAARAAAARG 100
    IPFTLSTVSV CPIEEVAPAI ERPMWFQLYV LKDRGFMRNA LERAKAAGVT 150
    TLVFTVDMPT PGARYRDAHS GMSGPNASLR RMLQAVTHPR WAWDVGVLGK 200
    PHDLGNISAY RGNPTGLQDY IGWLGANFDP SIAWKDLEWI REFWTGPMVI 250
    KGILDPEDAR DAVRFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGE 300
    LKILADSGIR SGLDVVRMLA LGADAVLLGR AFVYALAADG QAGVENLLTL 350
    IEKEMRVAMT LTGTHSIAQI SADALSRVTR EQANAVSP 388
    Length:388
    Mass (Da):41,842
    Last modified:March 1, 2005 - v1
    Checksum:i235429AB03A06DC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013598 Genomic DNA. Translation: AAW73276.1.
    RefSeqiYP_198661.1. NC_006834.1.

    Genome annotation databases

    EnsemblBacteriaiAAW73276; AAW73276; XOO0022.
    GeneIDi3264505.
    KEGGixoo:XOO0022.
    PATRICi24098719. VBIXanOry111333_0021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013598 Genomic DNA. Translation: AAW73276.1 .
    RefSeqi YP_198661.1. NC_006834.1.

    3D structure databases

    ProteinModelPortali Q5H6Z4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291331.XOO0022.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW73276 ; AAW73276 ; XOO0022 .
    GeneIDi 3264505.
    KEGGi xoo:XOO0022.
    PATRICi 24098719. VBIXanOry111333_0021.

    Phylogenomic databases

    eggNOGi COG1304.
    KOi K00101.
    OMAi PWFQLYM.
    OrthoDBi EOG6HMXBG.

    Enzyme and pathway databases

    BioCyci XORY291331:GJBV-20-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01559. L_lact_dehydr.
    InterProi IPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    IPR020920. L-lactate_DHase_bac.
    [Graphical view ]
    Pfami PF01070. FMN_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KACC10331 / KXO85.

    Entry informationi

    Entry nameiLLDD_XANOR
    AccessioniPrimary (citable) accession number: Q5H6Z4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3