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Q5H6B9

- PYRF_XANOR

UniProt

Q5H6B9 - PYRF_XANOR

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei19 – 191SubstrateUniRule annotation
    Binding sitei41 – 411SubstrateUniRule annotation
    Active sitei71 – 711Proton donorUniRule annotation
    Binding sitei124 – 1241SubstrateUniRule annotation
    Binding sitei185 – 1851SubstrateUniRule annotation
    Binding sitei194 – 1941SubstrateUniRule annotation
    Binding sitei214 – 2141Substrate; via amide nitrogenUniRule annotation
    Binding sitei215 – 2151SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciXORY291331:GJBV-217-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:XOO0247
    OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
    Taxonomic identifieri291331 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000006735: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243Orotidine 5'-phosphate decarboxylasePRO_0000241932Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi291331.XOO0247.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5H6B9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni69 – 7810Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226070.
    KOiK01591.
    OMAiVIASPHE.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5H6B9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRAPLPLAA HERLIFALDV PSHDEAIAWV DRLGDSVAFY KIGMELLASG    50
    EYFHVLDALA KRDKRVFVDL KFFDIPATVA GTIRRLAQWP VSYCTVHGWH 100
    AGMLQAAADA NHGAMRLLAV TVLTSMGRPD LAAMGIDREP VDVVVERALA 150
    AEAAGIDGVI ASGQEAGPIR RATGPAFSIV CPGIRPGGPV ADDQQRIVGV 200
    AQAFTDGADA IVVGRPIRLA ADPAAAAAAI QAEILAAVGQ DRS 243
    Length:243
    Mass (Da):25,502
    Last modified:March 1, 2005 - v1
    Checksum:i7929793A8FCDAFBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013598 Genomic DNA. Translation: AAW73501.1.
    RefSeqiYP_198886.1. NC_006834.1.

    Genome annotation databases

    EnsemblBacteriaiAAW73501; AAW73501; XOO0247.
    GeneIDi3264078.
    KEGGixoo:XOO0247.
    PATRICi24099236. VBIXanOry111333_0283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013598 Genomic DNA. Translation: AAW73501.1 .
    RefSeqi YP_198886.1. NC_006834.1.

    3D structure databases

    ProteinModelPortali Q5H6B9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291331.XOO0247.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW73501 ; AAW73501 ; XOO0247 .
    GeneIDi 3264078.
    KEGGi xoo:XOO0247.
    PATRICi 24099236. VBIXanOry111333_0283.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226070.
    KOi K01591.
    OMAi VIASPHE.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci XORY291331:GJBV-217-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KACC10331 / KXO85.

    Entry informationi

    Entry nameiPYRF_XANOR
    AccessioniPrimary (citable) accession number: Q5H6B9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3