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Q5H5H7

- PUR9_XANOR

UniProt

Q5H5H7 - PUR9_XANOR

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciXORY291331:GJBV-486-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:XOO0539
OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Taxonomic identifieri291331 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000006735: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Bifunctional purine biosynthesis protein PurHPRO_1000018989Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi291331.XOO0539.

Structurei

3D structure databases

ProteinModelPortaliQ5H5H7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5H5H7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASDFLPVRR ALLSVSDKTG LIDLARALVA RNVELLSTGG TAKAIREAGL
60 70 80 90 100
PVKDVAELTG FPEMMDGRVK TLHPLVHGGL LGRAGIDEAV MAEHGIAPID
110 120 130 140 150
LLVLNLYPFE SVTVKTDCTL ADAVENIDIG GPAMLRSAAK NFARVAVATD
160 170 180 190 200
PAQYADLLAE LEANNGQLSA AKRFALSVAA FNRVAQYDAA ISNYLSAVAD
210 220 230 240 250
SAETVPTRNP FPAQINSNFV KVMDLRYGEN PHQSGAFYRD LYPVPGTLAT
260 270 280 290 300
FQQLQGKELS YNNLADADAA WECVRQFDAP ACVIVKHANP CGVAVGAGCG
310 320 330 340 350
DAYELAYATD PTSAFGGILA FNKTLDAATA KAILDRQFVE VLIAPDYDAG
360 370 380 390 400
ALDYATKKAN VRVLKIPHGN GLNNYDTKRI GSGLLMQSAD NRGMSLGELS
410 420 430 440 450
VVTQRAPSEA ELGDLLFAWR VAKYVKSNAI VYAKDSRTIG VGAGQMSRVV
460 470 480 490 500
SAKIAALKAE EAKLTVVGSV MASDAFFPFR DGIDAAASAG IQAVIQPGGS
510 520
MRDGEVIAAA DEHGIAMVFT GVRHFRH
Length:527
Mass (Da):55,747
Last modified:March 1, 2005 - v1
Checksum:i0CD3FA8808630121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013598 Genomic DNA. Translation: AAW73793.1.
RefSeqiYP_199178.1. NC_006834.1.

Genome annotation databases

EnsemblBacteriaiAAW73793; AAW73793; XOO0539.
GeneIDi3263700.
KEGGixoo:XOO0539.
PATRICi24099905. VBIXanOry111333_0604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013598 Genomic DNA. Translation: AAW73793.1 .
RefSeqi YP_199178.1. NC_006834.1.

3D structure databases

ProteinModelPortali Q5H5H7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 291331.XOO0539.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW73793 ; AAW73793 ; XOO0539 .
GeneIDi 3263700.
KEGGi xoo:XOO0539.
PATRICi 24099905. VBIXanOry111333_0604.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci XORY291331:GJBV-486-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KACC10331 / KXO85.

Entry informationi

Entry nameiPUR9_XANOR
AccessioniPrimary (citable) accession number: Q5H5H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2005
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3