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Q5H5H7

- PUR9_XANOR

UniProt

Q5H5H7 - PUR9_XANOR

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciXORY291331:GJBV-486-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:XOO0539
    OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
    Taxonomic identifieri291331 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000006735: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Bifunctional purine biosynthesis protein PurHPRO_1000018989Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi291331.XOO0539.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5H5H7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5H5H7-1 [UniParc]FASTAAdd to Basket

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    MASDFLPVRR ALLSVSDKTG LIDLARALVA RNVELLSTGG TAKAIREAGL    50
    PVKDVAELTG FPEMMDGRVK TLHPLVHGGL LGRAGIDEAV MAEHGIAPID 100
    LLVLNLYPFE SVTVKTDCTL ADAVENIDIG GPAMLRSAAK NFARVAVATD 150
    PAQYADLLAE LEANNGQLSA AKRFALSVAA FNRVAQYDAA ISNYLSAVAD 200
    SAETVPTRNP FPAQINSNFV KVMDLRYGEN PHQSGAFYRD LYPVPGTLAT 250
    FQQLQGKELS YNNLADADAA WECVRQFDAP ACVIVKHANP CGVAVGAGCG 300
    DAYELAYATD PTSAFGGILA FNKTLDAATA KAILDRQFVE VLIAPDYDAG 350
    ALDYATKKAN VRVLKIPHGN GLNNYDTKRI GSGLLMQSAD NRGMSLGELS 400
    VVTQRAPSEA ELGDLLFAWR VAKYVKSNAI VYAKDSRTIG VGAGQMSRVV 450
    SAKIAALKAE EAKLTVVGSV MASDAFFPFR DGIDAAASAG IQAVIQPGGS 500
    MRDGEVIAAA DEHGIAMVFT GVRHFRH 527
    Length:527
    Mass (Da):55,747
    Last modified:March 1, 2005 - v1
    Checksum:i0CD3FA8808630121
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013598 Genomic DNA. Translation: AAW73793.1.
    RefSeqiWP_011257456.1. NC_006834.1.
    YP_199178.1. NC_006834.1.

    Genome annotation databases

    EnsemblBacteriaiAAW73793; AAW73793; XOO0539.
    GeneIDi3263700.
    KEGGixoo:XOO0539.
    PATRICi24099905. VBIXanOry111333_0604.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013598 Genomic DNA. Translation: AAW73793.1 .
    RefSeqi WP_011257456.1. NC_006834.1.
    YP_199178.1. NC_006834.1.

    3D structure databases

    ProteinModelPortali Q5H5H7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291331.XOO0539.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW73793 ; AAW73793 ; XOO0539 .
    GeneIDi 3263700.
    KEGGi xoo:XOO0539.
    PATRICi 24099905. VBIXanOry111333_0604.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci XORY291331:GJBV-486-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KACC10331 / KXO85.

    Entry informationi

    Entry nameiPUR9_XANOR
    AccessioniPrimary (citable) accession number: Q5H5H7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3