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Q5H496

- MDH_XANOR

UniProt

Q5H496 - MDH_XANOR

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Protein
Malate dehydrogenase
Gene
mdh, XOO0971
Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941Substrate By similarity
Binding sitei100 – 1001Substrate By similarity
Binding sitei107 – 1071NAD By similarity
Binding sitei114 – 1141NAD By similarity
Binding sitei133 – 1331Substrate By similarity
Binding sitei164 – 1641Substrate By similarity
Active sitei189 – 1891Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 177NAD By similarity
Nucleotide bindingi131 – 1333NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciXORY291331:GJBV-894-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:XOO0971
OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Taxonomic identifieri291331 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000006735: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Malate dehydrogenaseUniRule annotation
PRO_0000113405Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi291331.XOO0971.

Structurei

3D structure databases

ProteinModelPortaliQ5H496.
SMRiQ5H496. Positions 2-328.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiNCLIASK.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5H496-1 [UniParc]FASTAAdd to Basket

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MKAPVRVAVT GAAGQIGYAL LFRIASGEML GKDQPVILQL LELSNEKAQA    50
ALKGVMMELE DCAFPLLAGM VGTDDAEVAF KDIDVALLVG ARPRGPGMER 100
KDLLLENAKI FTAQGAALNK VAKRDVKVLV VGNPANTNAY IAMKSAPDLN 150
PKNFTAMLRL DHNRALSQLA LKLGKPVGGI EKLVVWGNHS PTMYPDYRFA 200
TSDGASIGDA INDQEWNAST FIPTVGKRGA AIIEARGLSS AASAANAAID 250
HVRDWVLGSN GKWVTMGVPS DGSYGISEGV IFGFPVTTEN GQYSLVKDLP 300
IDDFSQKYID KTLAELEEER SGVSHLLG 328
Length:328
Mass (Da):34,925
Last modified:March 1, 2005 - v1
Checksum:i86E329077197E71D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013598 Genomic DNA. Translation: AAW74225.1.
RefSeqiWP_011257835.1. NC_006834.1.
YP_199610.1. NC_006834.1.

Genome annotation databases

EnsemblBacteriaiAAW74225; AAW74225; XOO0971.
GeneIDi3264760.
KEGGixoo:XOO0971.
PATRICi24100870. VBIXanOry111333_1082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013598 Genomic DNA. Translation: AAW74225.1 .
RefSeqi WP_011257835.1. NC_006834.1.
YP_199610.1. NC_006834.1.

3D structure databases

ProteinModelPortali Q5H496.
SMRi Q5H496. Positions 2-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 291331.XOO0971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW74225 ; AAW74225 ; XOO0971 .
GeneIDi 3264760.
KEGGi xoo:XOO0971.
PATRICi 24100870. VBIXanOry111333_1082.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi NCLIASK.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci XORY291331:GJBV-894-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KACC10331 / KXO85.

Entry informationi

Entry nameiMDH_XANOR
AccessioniPrimary (citable) accession number: Q5H496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2005
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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