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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXORY291331:GJBV-1205-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:XOO1297
OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Taxonomic identifieri291331 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000006735 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258431Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi291331.XOO1297.

Structurei

3D structure databases

ProteinModelPortaliQ5H3C0.
SMRiQ5H3C0. Positions 1-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5H3C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYRDAGVDI DAGNALVERI KPLVKRSFRP EVMGGLGGFG ALFDLSGKYK
60 70 80 90 100
EPVLVSGTDG VGTKLKLAQQ LGRHDTIGID LVGMCVNDVL VQGAEPLFFL
110 120 130 140 150
DYFATGKLDV DTAAAVVGGI ARGCALSGCA LIGGETAEMP DMYPPGEYDL
160 170 180 190 200
AGFTVGAVEK SQLLDGAQVR DGDVLIGIAS SGPHSNGYSL IRKIYERAGA
210 220 230 240 250
PAEHVLDDGT KLIDALMAPT ALYVKPVLAL LKSHGQAIHA MAHITGGGLT
260 270 280 290 300
ENIIRVIPDG LGLDIDASAW TLPPVFAWLQ REGAVADAEM WRTFNCGIGF
310 320 330 340
VLIAAPAEAA ALEQALDAQS LAHWRIGQVV PAHGDERVRI D
Length:341
Mass (Da):35,824
Last modified:October 30, 2006 - v2
Checksum:i84F6800ECDA0B36F
GO

Sequence cautioni

The sequence AAW74551.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013598 Genomic DNA. Translation: AAW74551.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiAAW74551; AAW74551; XOO1297.
PATRICi24101621. VBIXanOry111333_1447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013598 Genomic DNA. Translation: AAW74551.1. Different initiation.

3D structure databases

ProteinModelPortaliQ5H3C0.
SMRiQ5H3C0. Positions 1-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi291331.XOO1297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW74551; AAW74551; XOO1297.
PATRICi24101621. VBIXanOry111333_1447.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
OrthoDBiEOG61CM1V.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.
BioCyciXORY291331:GJBV-1205-MONOMER.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KACC10331 / KXO85.

Entry informationi

Entry nameiPUR5_XANOR
AccessioniPrimary (citable) accession number: Q5H3C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 30, 2006
Last sequence update: October 30, 2006
Last modified: March 31, 2015
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.