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Q5H1D3

- GLND_XANOR

UniProt

Q5H1D3 - GLND_XANOR

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Protein
Bifunctional uridylyltransferase/uridylyl-removing enzyme
Gene
glnD, XOO1984
Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism By similarity.UniRule annotation

Catalytic activityi

UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII].UniRule annotation
Uridylyl-[protein-PII] + H2O = UMP + [protein-PII].UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity By similarity.UniRule annotation

GO - Molecular functioni

  1. [protein-PII] uridylyltransferase activity Source: UniProtKB-HAMAP
  2. amino acid binding Source: InterPro
  3. metal ion binding Source: InterPro
  4. phosphoric diester hydrolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
  2. regulation of nitrogen utilization Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciXORY291331:GJBV-1848-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional uridylyltransferase/uridylyl-removing enzyme
Short name:
UTase/UR
Alternative name(s):
Bifunctional [protein-PII] modification enzyme
Bifunctional nitrogen sensor protein
Including the following 2 domains:
[Protein-PII] uridylyltransferase (EC:2.7.7.59)
Short name:
PII uridylyltransferase
Short name:
UTase
[Protein-PII]-UMP uridylyl-removing enzyme (EC:3.1.4.-)
Short name:
UR
Gene namesi
Name:glnD
Ordered Locus Names:XOO1984
OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Taxonomic identifieri291331 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000006735: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Bifunctional uridylyltransferase/uridylyl-removing enzymeUniRule annotation
PRO_0000192779Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi291331.XOO1984.

Structurei

3D structure databases

ProteinModelPortaliQ5H1D3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini451 – 570120HD
Add
BLAST
Domaini692 – 77483ACT 1
Add
BLAST
Domaini798 – 86972ACT 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 332332UridylyltransferaseUniRule annotation
Add
BLAST
Regioni333 – 691359Uridylyl-removingUniRule annotation
Add
BLAST

Domaini

Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the GlnD family.
Contains 2 ACT domains.
Contains 1 HD domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2844.
HOGENOMiHOG000261778.
KOiK00990.
OMAiHHLLMSV.
OrthoDBiEOG6CCH44.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
HAMAPiMF_00277. PII_uridylyl_transf.
InterProiIPR002912. ACT_dom.
IPR010043. GlnD_Uridyltrans.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR002934. Nucleotidyltransferase.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF08335. GlnD_UR_UTase. 1 hit.
PF01966. HD. 1 hit.
PF01909. NTP_transf_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006288. PII_uridyltransf. 1 hit.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01693. UTase_glnD. 1 hit.
PROSITEiPS51671. ACT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5H1D3-1 [UniParc]FASTAAdd to Basket

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MTDAPAERPD PSVAGDADWA AQARPLLVHA DMRLRKRFDQ GEPIERLVAL    50
RARAVDQLMR NAWTRCIPAD SGLSLHAVGG YGRGELFPRS DVDVLVLGDS 100
VAQQRHEQHL SRLFALLWDV GLPISHAVRS PTQCMVAAAD QTVLTALIES 150
RALVADAAAR AALAAAIAPQ RVWPPRDFFQ AKREELLARH QRFGDTADNL 200
EPDIKDGPGG LRDLQTLGCM ALRAFGVKDV EALVGLGHVG CDEAAALRRE 250
REELARLRFG LHIVANRPEE RLRFDYQKTL AERLGFADDL ESLGVEKMMQ 300
RFYRSAALIR RISDRLLQRF EEQFDGEATP ESLGGGFSLR RGYLAADSDS 350
WPGDDVLQVF ALFVHWAAHR EVRGLHSLTA RALAEVLREF PAYDVADATA 400
RELFMALLRG TRAVETLNRM ARLGVLGQWI PAFASVSGRM QFDLFHVYTV 450
DQHTLMVLRN IALFAAGRAD ERFSIAHEVW PRLRKPELLL LAGLFHDIAK 500
GRGGDHSELG AVDTRAFCLA HRLSEGDTEL VTWLVEQHLR MSVTAQKQDI 550
SDPEVIHRFA TLVGTRERLD YLYLLTCADI AGTSPKLWNA WKDRLLADLY 600
FAARRALREG VEHPPPREER LREARESARA LMQAQGHDDA TIDRQFAGMP 650
DENFLRFRPE QLAWQAASLI EVEIAQTLVK ARRAVPDNDA LEVFVYSPDR 700
DGLFAAIVAT LDRKGYGIHR ARVLDAPHDA IFDVFEVLPR DTYADGDPQR 750
LAATLRQVLA GDLQQVRPAR RAVPGQLRHF RFAPRVEFSE SADGRRTRIS 800
LVAPDRPGLL ADVAHVLRVQ HLRVHDARIA TFGERAEDQF QITDEHDRPL 850
SESARQALRD ALCACLDPV 869
Length:869
Mass (Da):97,350
Last modified:November 8, 2005 - v2
Checksum:iEF45D7310C81BC66
GO

Sequence cautioni

The sequence AAW75238.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013598 Genomic DNA. Translation: AAW75238.1. Different initiation.
RefSeqiYP_200623.1. NC_006834.1.

Genome annotation databases

EnsemblBacteriaiAAW75238; AAW75238; XOO1984.
GeneIDi3264479.
KEGGixoo:XOO1984.
PATRICi24103115. VBIXanOry111333_2194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013598 Genomic DNA. Translation: AAW75238.1 . Different initiation.
RefSeqi YP_200623.1. NC_006834.1.

3D structure databases

ProteinModelPortali Q5H1D3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 291331.XOO1984.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW75238 ; AAW75238 ; XOO1984 .
GeneIDi 3264479.
KEGGi xoo:XOO1984.
PATRICi 24103115. VBIXanOry111333_2194.

Phylogenomic databases

eggNOGi COG2844.
HOGENOMi HOG000261778.
KOi K00990.
OMAi HHLLMSV.
OrthoDBi EOG6CCH44.

Enzyme and pathway databases

BioCyci XORY291331:GJBV-1848-MONOMER.

Family and domain databases

Gene3Di 1.10.3210.10. 1 hit.
HAMAPi MF_00277. PII_uridylyl_transf.
InterProi IPR002912. ACT_dom.
IPR010043. GlnD_Uridyltrans.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR002934. Nucleotidyltransferase.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF08335. GlnD_UR_UTase. 1 hit.
PF01966. HD. 1 hit.
PF01909. NTP_transf_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006288. PII_uridyltransf. 1 hit.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01693. UTase_glnD. 1 hit.
PROSITEi PS51671. ACT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KACC10331 / KXO85.

Entry informationi

Entry nameiGLND_XANOR
AccessioniPrimary (citable) accession number: Q5H1D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 11, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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