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Q5H0L1

- HISX_XANOR

UniProt

Q5H0L1 - HISX_XANOR

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Protein
Histidinol dehydrogenase
Gene
hisD, XOO2256
Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei189 – 1891NAD By similarity
Binding sitei212 – 2121NAD By similarity
Binding sitei237 – 2371Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Active sitei326 – 3261Proton acceptor By similarity
Active sitei327 – 3271Proton acceptor By similarity
Binding sitei327 – 3271Substrate By similarity
Metal bindingi360 – 3601Zinc By similarity
Binding sitei360 – 3601Substrate By similarity
Binding sitei414 – 4141Substrate By similarity
Metal bindingi419 – 4191Zinc By similarity
Binding sitei419 – 4191Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciXORY291331:GJBV-2104-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:XOO2256
OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Taxonomic identifieri291331 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000006735: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenaseUniRule annotation
PRO_0000135884Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi291331.XOO2256.

Structurei

3D structure databases

ProteinModelPortaliQ5H0L1.
SMRiQ5H0L1. Positions 2-428.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiSQDSRCV.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5H0L1-1 [UniParc]FASTAAdd to Basket

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MKILDWSQLD VAARTDALTR PVQTVAAQTR NAVAALIADV RTRGDAALRE    50
ITARFDGVSL ERFAVSEAEF AAAEAAVAPE LRQAMQDAVA RIDTFHRAGM 100
SEGYAVETAP GVVCEKIVRP IGRVGLYVPA GSAPLPSTAL MLGVPARLAG 150
CRAVVLCTPP RKDGSVDPAV LVAAWLTGVR RVFKLGGAQA IAAMAYGTES 200
VPSCDKLFGP GNSYVTEAKQ QVAQSGAAAI DMPAGPSEVL VIADAGAQAA 250
FVAADLLSQA EHGADSQVLL LSDSDVLIDA VQAQLEIQLA HLSRADIARQ 300
ALAQSRLIKV QTLDEAFAIS NRYAPEHLIL ALREPRAWLA QVEAAGSVFL 350
GDYTPEALGD YCSGTNHVLP TSGAARAYSG VSVASFQNMF SVQAASKAGI 400
AGIGECALIL ARAEGLDAHA NAVALRMGVA A 431
Length:431
Mass (Da):44,705
Last modified:March 1, 2005 - v1
Checksum:i579CED70E3CE561A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013598 Genomic DNA. Translation: AAW75510.1.
RefSeqiYP_200895.1. NC_006834.1.

Genome annotation databases

EnsemblBacteriaiAAW75510; AAW75510; XOO2256.
GeneIDi3265715.
KEGGixoo:XOO2256.
PATRICi24103716. VBIXanOry111333_2493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013598 Genomic DNA. Translation: AAW75510.1 .
RefSeqi YP_200895.1. NC_006834.1.

3D structure databases

ProteinModelPortali Q5H0L1.
SMRi Q5H0L1. Positions 2-428.
ModBasei Search...

Protein-protein interaction databases

STRINGi 291331.XOO2256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW75510 ; AAW75510 ; XOO2256 .
GeneIDi 3265715.
KEGGi xoo:XOO2256.
PATRICi 24103716. VBIXanOry111333_2493.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi SQDSRCV.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci XORY291331:GJBV-2104-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KACC10331 / KXO85.

Entry informationi

Entry nameiHISX_XANOR
AccessioniPrimary (citable) accession number: Q5H0L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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