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Protein

Imidazole glycerol phosphate synthase subunit HisF

Gene

hisF

Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.UniRule annotation

Catalytic activityi

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11UniRule annotation1
Active sitei130UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00010.

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazole glycerol phosphate synthase subunit HisFUniRule annotation (EC:4.1.3.-UniRule annotation)
Alternative name(s):
IGP synthase cyclase subunitUniRule annotation
IGP synthase subunit HisFUniRule annotation
ImGP synthase subunit HisFUniRule annotation
Short name:
IGPS subunit HisFUniRule annotation
Gene namesi
Name:hisFUniRule annotation
Ordered Locus Names:XOO2261
OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Taxonomic identifieri291331 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000006735 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001422691 – 258Imidazole glycerol phosphate synthase subunit HisFAdd BLAST258

Interactioni

Subunit structurei

Heterodimer of HisH and HisF.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5H0K6.
SMRiQ5H0K6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000224612.
KOiK02500.

Family and domain databases

CDDicd04731. HisF. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01013. HisF. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR004651. HisF.
IPR011060. RibuloseP-bd_barrel.
PfamiView protein in Pfam
PF00977. His_biosynth. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00735. hisF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5H0K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRRIIPCL DVRNGRVVKG VKFHDHIDMG DIVELALRYR AQGADELVFY
60 70 80 90 100
DIGASPEGRS VDYTWVERVA RLIDIPFCVA GGIGDVETAR AVLHAGADKI
110 120 130 140 150
SINSPALGRP QLISELADAF GVQCVVVGID SIREDDGQWR VRRYTGDPSK
160 170 180 190 200
TQALPMRTLD WVAEAQRLGA GEIVLNCMDN DGVRRGYDIA QLRQVRALCH
210 220 230 240 250
VPLIASGGAG EMQHFADVFD QADVDGALAA SVFHSGAIPI PELKQFLRAQ

QIEVRDGQ
Length:258
Mass (Da):28,201
Last modified:January 10, 2006 - v2
Checksum:i107F96B6037B18AC
GO

Sequence cautioni

The sequence AAW75515 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013598 Genomic DNA. Translation: AAW75515.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiAAW75515; AAW75515; XOO2261.
KEGGixoo:XOO2261.

Similar proteinsi

Entry informationi

Entry nameiHIS6_XANOR
AccessioniPrimary (citable) accession number: Q5H0K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: July 5, 2017
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families