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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi380 – 387ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:XOO2297
OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Taxonomic identifieri291331 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000006735 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalUniRule annotationAdd BLAST21
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei157 – 177HelicalUniRule annotationAdd BLAST21
Transmembranei261 – 281HelicalUniRule annotationAdd BLAST21
Transmembranei283 – 303HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716661 – 589Lipid A export ATP-binding/permease protein MsbAAdd BLAST589

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5H0H0.
SMRiQ5H0H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 314ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini346 – 582ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085.
OMAiKVFSHEP.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5H0H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSTDRPVS VSSWRTYRRL VAFAKPYRLL LVAALIAALI EAAGTTGFLA
60 70 80 90 100
LMKPITDETF IYKNAEVSRW LPVQIILLFV VRGIAGYITD MAMGKSARSI
110 120 130 140 150
ARDLRIKVMA KYLRLPGSRF DSEPVPSMLI RLGSDSDQVA QAAVDAIKVM
160 170 180 190 200
IQQSLQVIGA LALMLWHSWQ VTLTILVLAP VLAWVMDKVA RRYRRISHSI
210 220 230 240 250
QESGAHLLQA ADQTLSSHQE VKIYGAQQTE MERYGALADR NLRLAMKVES
260 270 280 290 300
TRGISTATVQ MIGAIGLSAL LFVAGAQALA GRLTAGDFVV LMTSMLTIIP
310 320 330 340 350
GLKQLTNVQN MVQRGLASAE RLFSVLDSPD EPDQGAVALT RAKGLIEFRD
360 370 380 390 400
VTARYPGQVN PALADVSFIA QPGTVTAIVG RSGSGKSSLI KLIPRFYDAE
410 420 430 440 450
AGQILLDGQP VQAYALADLR RQIALVGQQV MLFDGSIAEN VAFGEMRSAD
460 470 480 490 500
ASQLERAILG ANAMEFVAQL PEGLQSHVGA KGGRLSGGQR QRLAIARAML
510 520 530 540 550
KDAPILILDE ATAALDNESE RLVQDALHKL MPDRTTLVIA HRLSTIEHAD
560 570 580
QVLVMDQGRI VERGTHHELL AQGGLYSHLH GMQFRERQA
Length:589
Mass (Da):64,108
Last modified:March 1, 2005 - v1
Checksum:iBB9C5B7B37DD1130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013598 Genomic DNA. Translation: AAW75551.1.

Genome annotation databases

EnsemblBacteriaiAAW75551; AAW75551; XOO2297.
KEGGixoo:XOO2297.

Similar proteinsi

Entry informationi

Entry nameiMSBA_XANOR
AccessioniPrimary (citable) accession number: Q5H0H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2005
Last modified: July 5, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families