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Q5GT41 (MDH_WOLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:Wbm0244
OrganismWolbachia sp. subsp. Brugia malayi (strain TRS) [Complete proteome] [HAMAP]
Taxonomic identifier292805 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Malate dehydrogenase HAMAP-Rule MF_00487
PRO_0000113478

Regions

Nucleotide binding12 – 176NAD By similarity
Nucleotide binding121 – 1233NAD By similarity

Sites

Active site1781Proton acceptor By similarity
Binding site361NAD By similarity
Binding site851Substrate By similarity
Binding site911Substrate By similarity
Binding site981NAD By similarity
Binding site1231Substrate By similarity
Binding site1541Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5GT41 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 759FBC8C6189EF32

FASTA31634,224
        10         20         30         40         50         60 
MTVQRKKISL IGAGNIGGAL AHMVTLRELG DVVLFDVNDG IPQGKALDIA ESSPIGGFSV 

        70         80         90        100        110        120 
NIIGTNRYGD IKNSDAIIIT AGIARKPGMS RDDLLQTNAK VMKEVGENIR KYSPNAFVIV 

       130        140        150        160        170        180 
VTNPLDAMVS VVHKFSNLPA NMIVGMAGVL DSSRFRYFLA RELNISVEDV SAFVLGGHGD 

       190        200        210        220        230        240 
TMVPLIRCAS IAGIPLTQII DMGLITQEKV DEIVKRTRNG GKEIIDLLKS GSAYYAPASS 

       250        260        270        280        290        300 
SIYMLESYLR DEKRILPCAT YLNGEYGVKD LFIGVPVIIG KNGIEKVLEV KMDDSEQEMF 

       310 
NKSVNAVKEL VKSLSL 

« Hide

References

[1]"The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode."
Foster J., Ganatra M., Kamal I., Ware J., Makarova K., Ivanova N., Bhattacharyya A., Kapatral V., Kumar S., Posfai J., Vincze T., Ingram J., Moran L., Lapidus A., Omelchenko M., Kyrpides N., Ghedin E., Wang S. expand/collapse author list , Goltsman E., Joukov V., Ostrovskaya O., Tsukerman K., Mazur M., Comb D., Koonin E., Slatko B.
PLoS Biol. 3:599-614(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TRS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017321 Genomic DNA. Translation: AAW70833.1.
RefSeqYP_198075.1. NC_006833.1.

3D structure databases

ProteinModelPortalQ5GT41.
SMRQ5GT41. Positions 5-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING292805.Wbm0244.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW70833; AAW70833; Wbm0244.
GeneID3266757.
KEGGwbm:Wbm0244.
PATRIC24032031. VBIWolEnd7741_0395.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAYAPSAFV.
OrthoDBEOG6091FG.

Enzyme and pathway databases

BioCycWEND292805:GH18-280-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_WOLTR
AccessionPrimary (citable) accession number: Q5GT41
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families