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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Wolbachia sp. subsp. Brugia malayi (strain TRS)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:Wbm0246
OrganismiWolbachia sp. subsp. Brugia malayi (strain TRS)
Taxonomic identifieri292805 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000000534 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002319431 – 161RNA pyrophosphohydrolaseAdd BLAST161

Interactioni

Protein-protein interaction databases

STRINGi292805.Wbm0246

Structurei

3D structure databases

ProteinModelPortaliQ5GT39
SMRiQ5GT39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 149Nudix hydrolaseUniRule annotationAdd BLAST143

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 61Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EJF Bacteria
COG0494 LUCA
HOGENOMiHOG000066722
KOiK08311
OMAiRPCVGIM
OrthoDBiPOG091H0392

Family and domain databases

CDDicd03671 Ap4A_hydrolase_plant_like, 1 hit
HAMAPiMF_00298 Nudix_RppH, 1 hit
InterProiView protein in InterPro
IPR020476 Nudix_hydrolase
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
IPR022927 RppH
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR00502 NUDIXFAMILY
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q5GT39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEQKDKYRP CVGIMLFNKQ GHVFIGKRFD SDSYWQMPQG GIDDGEKLEQ
60 70 80 90 100
AALRELLEEV GTDKAKIIAK NKDWIYYNLP EEVIPTCWNG RYSGQKQRWF
110 120 130 140 150
LMKFYGEGKD ININYTDHPE FKEWRWQSVD NLVAGAIPFK KEVYKTVIEE
160
FSSQIKVSII K
Length:161
Mass (Da):18,967
Last modified:March 1, 2005 - v1
Checksum:iBE80B29520C211FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017321 Genomic DNA Translation: AAW70835.1

Genome annotation databases

EnsemblBacteriaiAAW70835; AAW70835; Wbm0246
KEGGiwbm:Wbm0246

Similar proteinsi

Entry informationi

Entry nameiRPPH_WOLTR
AccessioniPrimary (citable) accession number: Q5GT39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2005
Last modified: January 31, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome