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Protein

Elongation factor Tu 1

Gene

tuf1

Organism
Wolbachia sp. subsp. Brugia malayi (strain TRS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 338GTPUniRule annotation
Nucleotide bindingi83 – 875GTPUniRule annotation
Nucleotide bindingi138 – 1414GTPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWEND292805:GH18-388-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu 1UniRule annotation
Short name:
EF-Tu 1UniRule annotation
Gene namesi
Name:tuf1UniRule annotation
Ordered Locus Names:Wbm0343
OrganismiWolbachia sp. subsp. Brugia malayi (strain TRS)
Taxonomic identifieri292805 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000000534 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Elongation factor Tu 1PRO_0000337573Add
BLAST

Proteomic databases

PRIDEiQ5GSU2.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi292805.Wbm0343.

Structurei

3D structure databases

ProteinModelPortaliQ5GSU2.
SMRiQ5GSU2. Positions 17-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 208192tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 338G1By similarity
Regioni62 – 665G2By similarity
Regioni83 – 864G3By similarity
Regioni138 – 1414G4By similarity
Regioni175 – 1773G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiDEGGRHN.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5GSU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAVEATAQ VVEAFGKPHV NVGTIGHVDH GKTTLTAAIT KHYGNFVAYD
60 70 80 90 100
QIDKAPEERK RGITIATAHV EYQTEKRHYA HVDCPGHADY VKNMIVGAAQ
110 120 130 140 150
MDAAILVVSG VDGPMPQTRE HILLAKQVGV GYIVVYINKA DVSDPDMIGL
160 170 180 190 200
VEMEVRELLS KYGFPGDEVP VVIGSALKAL EDDDGEYGKK SIDKLMERLD
210 220 230 240 250
DYVEVPPRSV DLPFLLPIED VFSISGRGTV VTGRIEKGEI KIGDEIEIIG
260 270 280 290 300
LKATQKTTCT GVEMFKKLLE KGSAGLNVGI LLRGTKREEV ERGQVLAKPG
310 320 330 340 350
TITPHRKFKA EVYILKKEEG GRHTPFFANY QPQFYLRTTD VTGSIKLLEG
360 370 380 390
KEMVMPGDNV SIEVELQVPI AMDKGLRFAI REGGRTVGSG VVSEILEWV
Length:399
Mass (Da):43,712
Last modified:March 1, 2005 - v1
Checksum:i3814F7364E3118E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017321 Genomic DNA. Translation: AAW70932.1.
RefSeqiWP_011256542.1. NC_006833.1.
YP_198174.1. NC_006833.1.

Genome annotation databases

EnsemblBacteriaiAAW70932; AAW70932; Wbm0343.
KEGGiwbm:Wbm0343.
PATRICi24032317. VBIWolEnd7741_0536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017321 Genomic DNA. Translation: AAW70932.1.
RefSeqiWP_011256542.1. NC_006833.1.
YP_198174.1. NC_006833.1.

3D structure databases

ProteinModelPortaliQ5GSU2.
SMRiQ5GSU2. Positions 17-396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi292805.Wbm0343.

Proteomic databases

PRIDEiQ5GSU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW70932; AAW70932; Wbm0343.
KEGGiwbm:Wbm0343.
PATRICi24032317. VBIWolEnd7741_0536.

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiDEGGRHN.
OrthoDBiEOG6R5C6X.

Enzyme and pathway databases

BioCyciWEND292805:GH18-388-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TRS.

Entry informationi

Entry nameiEFTU1_WOLTR
AccessioniPrimary (citable) accession number: Q5GSU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2005
Last modified: June 24, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.