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Q5GST1

- DUT_WOLTR

UniProt

Q5GST1 - DUT_WOLTR

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
dut, Wbm0355
Organism
Wolbachia sp. subsp. Brugia malayi (strain TRS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871Substrate By similarity
Binding sitei101 – 1011Substrate; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciWEND292805:GH18-401-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:Wbm0355
OrganismiWolbachia sp. subsp. Brugia malayi (strain TRS)
Taxonomic identifieri292805 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000000534: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation
PRO_0000231435Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292805.Wbm0355.

Structurei

3D structure databases

ProteinModelPortaliQ5GST1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 763Substrate binding By similarity
Regioni91 – 933Substrate binding By similarity

Sequence similaritiesi

Belongs to the dUTPase family.

Phylogenomic databases

eggNOGiCOG0756.
HOGENOMiHOG000028968.
KOiK01520.
OMAiEPMERIA.
OrthoDBiEOG689HXK.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00116. dUTPase_bact.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5GST1-1 [UniParc]FASTAAdd to Basket

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MGRIQRNKIK VEIKKLSHGK DLPLPCYATM QSAGMDLYAA LGNSIVLNPL    50
ERLLIPTGIV IVIPNGFEGQ IRPRSGLAAK YGITVLNSPG TIDSDYRGEV 100
KVCLINLSNQ PYEIKRGDRI AQILIAPVFR VIWDDAERLC TEETERSAGG 150
FGSSGR 156
Length:156
Mass (Da):17,097
Last modified:March 1, 2005 - v1
Checksum:iA29445204210AEF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017321 Genomic DNA. Translation: AAW70943.1.
RefSeqiYP_198185.1. NC_006833.1.

Genome annotation databases

EnsemblBacteriaiAAW70943; AAW70943; Wbm0355.
GeneIDi3266545.
KEGGiwbm:Wbm0355.
PATRICi24032361. VBIWolEnd7741_0558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017321 Genomic DNA. Translation: AAW70943.1 .
RefSeqi YP_198185.1. NC_006833.1.

3D structure databases

ProteinModelPortali Q5GST1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292805.Wbm0355.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW70943 ; AAW70943 ; Wbm0355 .
GeneIDi 3266545.
KEGGi wbm:Wbm0355.
PATRICi 24032361. VBIWolEnd7741_0558.

Phylogenomic databases

eggNOGi COG0756.
HOGENOMi HOG000028968.
KOi K01520.
OMAi EPMERIA.
OrthoDBi EOG689HXK.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci WEND292805:GH18-401-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00116. dUTPase_bact.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TRS.

Entry informationi

Entry nameiDUT_WOLTR
AccessioniPrimary (citable) accession number: Q5GST1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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