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Q5GSK8 (Q5GSK8_WOLTR) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA pseudouridine synthase A HAMAP-Rule MF_00171

EC=5.4.99.12 HAMAP-Rule MF_00171
Alternative name(s):
tRNA pseudouridine(38-40) synthase HAMAP-Rule MF_00171
tRNA pseudouridylate synthase I HAMAP-Rule MF_00171
tRNA-uridine isomerase I HAMAP-Rule MF_00171
Gene names
Name:truA HAMAP-Rule MF_00171
Ordered Locus Names:Wbm0428 EMBL AAW71016.1
OrganismWolbachia sp. subsp. Brugia malayi (strain TRS) [Complete proteome] [HAMAP] EMBL AAW71016.1
Taxonomic identifier292805 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs By similarity. HAMAP-Rule MF_00171 SAAS SAAS020097

Catalytic activity

tRNA uridine(38-40) = tRNA pseudouridine(38-40). HAMAP-Rule MF_00171 RuleBase RU003792 SAAS SAAS020097

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00171

Sequence similarities

Belongs to the tRNA pseudouridine synthase TruA family. HAMAP-Rule MF_00171 RuleBase RU003792

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site561Nucleophile By similarity HAMAP-Rule MF_00171 PIRSR PIRSR001430-1
Binding site1151Substrate By similarity HAMAP-Rule MF_00171 PIRSR PIRSR001430-2

Sequences

Sequence LengthMass (Da)Tools
Q5GSK8 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 638086EB69435627

FASTA24928,367
        10         20         30         40         50         60 
MDFAVRYKIT IEYNGSSFSG WQKQQHSANS IQETIENAIF NFSGEKVTLH CGGRTDAGVH 

        70         80         90        100        110        120 
ALGQVAHFDM ERKFELYKIR NAINYHLKSI PIVVLNAETV DNTFHSRFSA KKRYYEYRII 

       130        140        150        160        170        180 
NRYAPAALEA GYAWQVFNPL DVNIMREAAK YLLGKHNLLS FRSKDCQATN PIRTIDDIDI 

       190        200        210        220        230        240 
VQNGSHIYIK ISAISFLHNQ VRIIVGTLVE FGKSRTNPQK MLNILNQCKR NAAGVTAPPF 


GLYLAKIDY 

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References

[1]"The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode."
Foster J., Ganatra M., Kamal I., Ware J., Makarova K., Ivanova N., Bhattacharyya A., Kapatral V., Kumar S., Posfai J., Vincze T., Ingram J., Moran L., Lapidus A., Omelchenko M., Kyrpides N., Ghedin E., Wang S. expand/collapse author list , Goltsman E., Joukov V., Ostrovskaya O., Tsukerman K., Mazur M., Comb D., Koonin E., Slatko B.
PLoS Biol. 3:599-614(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TRS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017321 Genomic DNA. Translation: AAW71016.1.
RefSeqYP_198258.1. NC_006833.1.

3D structure databases

ProteinModelPortalQ5GSK8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING292805.Wbm0428.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW71016; AAW71016; Wbm0428.
GeneID3266792.
KEGGwbm:Wbm0428.
PATRIC24032599. VBIWolEnd7741_0673.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0101.
HOGENOMHOG000248672.
KOK06173.
OMAWDPFRLS.
OrthoDBEOG6Z9B4R.

Enzyme and pathway databases

BioCycWEND292805:GH18-489-MONOMER.

Family and domain databases

Gene3D3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPMF_00171. TruA.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERPTHR11142. PTHR11142. 1 hit.
PfamPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00071. hisT_truA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ5GSK8_WOLTR
AccessionPrimary (citable) accession number: Q5GSK8
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2005
Last sequence update: March 1, 2005
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)