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Q5GSB8

- DAPF_WOLTR

UniProt

Q5GSB8 - DAPF_WOLTR

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Wolbachia sp. subsp. Brugia malayi (strain TRS)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141SubstrateUniRule annotation
    Binding sitei42 – 421SubstrateUniRule annotation
    Binding sitei60 – 601SubstrateUniRule annotation
    Active sitei69 – 691Proton donor/acceptorUniRule annotation
    Binding sitei151 – 1511SubstrateUniRule annotation
    Sitei153 – 1531Important for catalytic activityUniRule annotation
    Binding sitei184 – 1841SubstrateUniRule annotation
    Sitei202 – 2021Important for catalytic activityUniRule annotation
    Active sitei211 – 2111Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciWEND292805:GH18-592-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:Wbm0518
    OrganismiWolbachia sp. subsp. Brugia malayi (strain TRS)
    Taxonomic identifieri292805 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
    ProteomesiUP000000534: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259Diaminopimelate epimerasePRO_1000058546Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi69 ↔ 211

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi292805.Wbm0518.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5GSB8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni69 – 713Substrate bindingUniRule annotation
    Regioni202 – 2032Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220466.
    KOiK01778.
    OMAiDGVWMTG.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5GSB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSQSPKRMY GTGNNFVIID SRSINNLNWN YREIANQNGC DQIIVITNSS    50
    AADCFMHIYN ADGGEVEMCG NAARCVGYLI MSEKSTEYAT IELVNKRILE 100
    CFKVGGRSIK VNMGKPLFKW HEIPLSAKCD PLHLPIELEM LKDPVAVNIG 150
    NPHMVFFVDN ISEIPLQSLG PKLEKHTLFP KKVNVNIAQV EKSGEISLRV 200
    WERGTGITAS CGSAACAALI ASVLRGYLIT RQTSVNLPGG KLLIEWPDNI 250
    FMTGDIGFL 259
    Length:259
    Mass (Da):28,565
    Last modified:March 1, 2005 - v1
    Checksum:i07C9AC6E02AF14DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017321 Genomic DNA. Translation: AAW71106.1.
    RefSeqiWP_011256716.1. NC_006833.1.
    YP_198348.1. NC_006833.1.

    Genome annotation databases

    EnsemblBacteriaiAAW71106; AAW71106; Wbm0518.
    GeneIDi3267088.
    KEGGiwbm:Wbm0518.
    PATRICi24032887. VBIWolEnd7741_0814.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017321 Genomic DNA. Translation: AAW71106.1 .
    RefSeqi WP_011256716.1. NC_006833.1.
    YP_198348.1. NC_006833.1.

    3D structure databases

    ProteinModelPortali Q5GSB8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292805.Wbm0518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW71106 ; AAW71106 ; Wbm0518 .
    GeneIDi 3267088.
    KEGGi wbm:Wbm0518.
    PATRICi 24032887. VBIWolEnd7741_0814.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220466.
    KOi K01778.
    OMAi DGVWMTG.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci WEND292805:GH18-592-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TRS.

    Entry informationi

    Entry nameiDAPF_WOLTR
    AccessioniPrimary (citable) accession number: Q5GSB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3