Q5GS87 (SURE_WOLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	Wbm0549

Organism

Wolbachia sp. subsp. Brugia malayi (strain TRS) [Complete proteome] [HAMAP]

Taxonomic identifier

292805 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachieae › Wolbachia

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235668
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	40	1	Divalent metal cation By similarity
	Metal binding	94	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5GS87 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: F66D315E65C3D755	FASTA	250	27,220
	10 20 30 40 50 60 MIILITNDDG FESEGIKLLK EVARNFASEI WIVAPDTDRS GAARSLDHPV KQSIRINQHN 70 80 90 100 110 120 EREFSVSGTP ADCVIIALNK IMDKKPDLVL SGVNIGSNVG DDVCYSGTIG AVMEGAARSI 130 140 150 160 170 180 PSIALSQAYH GGINWYNTKI FAPKVIAKLV KVGWPKNIAM SINFSATEKV KGVEFAEQGE 190 200 210 220 230 240 YNIDGDLTFT ENPDGSLSLN WSREHLGSGS VGKIKEGFIT ITPIKLDFTD YDTLNAMKNS 250 YAEEFSSIVN

References

[1]

"The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode." Foster J., Ganatra M., Kamal I., Ware J., Makarova K., Ivanova N., Bhattacharyya A., Kapatral V., Kumar S., Posfai J., Vincze T., Ingram J., Moran L., Lapidus A., Omelchenko M., Kyrpides N., Ghedin E., Wang S. , Goltsman E., Joukov V., Ostrovskaya O., Tsukerman K., Mazur M., Comb D., Koonin E., Slatko B. PLoS Biol. 3:599-614(2005) [PubMed: 15780005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TRS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017321 Genomic DNA. Translation: AAW71137.1.
RefSeq	YP_198379.1. NC_006833.1.
3D structure databases
ProteinModelPortal	Q5GS87.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5GS87.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBWOLT00000003018; EBWOLP00000002713; EBWOLG00000003018.
GeneID	3266667.
GenomeReviews	Gene locus Wbm0549 in contig AE017321_GR.
KEGG	wbm:Wbm0549.
PATRIC	24033033. VBIWolEnd7741_0886.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0496.
GeneTree	EBGT00050000030883.
HOGENOM	HBG600532.
OMA	MEGAARS.
PhylomeDB	Q5GS87.
ProtClustDB	CLSK740019.
Enzyme and pathway databases
BioCyc	WPIP80849:WBM0549-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_WOLTR

Accession

Primary (citable) accession number: Q5GS87

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program