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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolbachia sp. subsp. Brugia malayi (strain TRS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei611ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Wbm0605
OrganismiWolbachia sp. subsp. Brugia malayi (strain TRS)
Taxonomic identifieri292805 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000000534 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094641 – 865Leucine--tRNA ligaseAdd BLAST865

Interactioni

Protein-protein interaction databases

STRINGi292805.Wbm0605.

Structurei

3D structure databases

ProteinModelPortaliQ5GS31.
SMRiQ5GS31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46"HIGH" regionAdd BLAST11
Motifi608 – 612"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T. Bacteria.
COG0495. LUCA.
HOGENOMiHOG000200747.
KOiK01869.
OMAiTFMVLAP.
OrthoDBiPOG091H01JZ.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 2 hits.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5GS31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDFKNVEK FYQDRWDFSI GKNNEQGKCY VLEMFPYPSG KIHMGHLRNY
60 70 80 90 100
VIGDVIARYK RACGFEVLHP IGWDAFGLPA ENAARDNNVN PAAWTKENID
110 120 130 140 150
NMRAQLKSIG LSYNWERELS TCEADYYKHE QKFFLDFLKQ GLVYRKKSWV
160 170 180 190 200
NWDPIDQTVL ANEQVVDGKG WRSGAIVEKR ELSQWFLKIT DFAEDLLECL
210 220 230 240 250
QGLENWPEKV KMMQDRWIGK SEGVTIEFKI VGLNKKLKVF TTCPHTLFGA
260 270 280 290 300
SFCAVAIEHP IVQDLMSKEI QDLISSIKIQ GKNNEKVGIY TGLNVKHPFL
310 320 330 340 350
DKELPLYVAN FVLMEYREGA IFGCPAHDQR DFEFAQEYDL PIIPVISSAR
360 370 380 390 400
LGIIPACDQG SYTGSQCQAT RMADGLNEEY TNNSIMFNSE FLNGLTVSEA
410 420 430 440 450
RKVIVEKLEE KGIGKKTINY RLHDWGVSRQ RYWGCPIPVI YCKNCGTVPV
460 470 480 490 500
PEEDLPVTLP TDVDFTSGGN PLDKHPTWKF VNCPKCKEQA ERETDTFDTF
510 520 530 540 550
FESSWYFAAF CSENKSIDKN ACNRFMPVDY YIGGIEHAIL HLLYSRFFCR
560 570 580 590 600
ALTKCGYFNV KEPFSTLITQ GMVCHVTYKD KNGKWLFPEE AKRLITQGAK
610 620 630 640 650
IQVGKVEKMS KSKKNTVDPN FIIEKYGADT ARLFVLSDTP PEKDMEWSND
660 670 680 690 700
GVEGCSRYIN KLWRMVMQFK PVVILNQSPV KQVADTEIQK EDMLSHAGMI
710 720 730 740 750
PDKNVTGKFL GYRKKIHKLL HGLTDDLENC RLNCVVAKFR EMTNLIAEID
760 770 780 790 800
VKTGKSLINE GICILIRVVE PFIPHLAESL WREIGGEGML YLQPWPKAAK
810 820 830 840 850
SLLIDDVVTV AVQINGKLRA TIEVAINLHQ EELKQIAINS VSNRVDQSKV
860
RAVYAVSNKI VNIVT
Length:865
Mass (Da):98,820
Last modified:March 1, 2005 - v1
Checksum:iCACA7BBB8CECF813
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017321 Genomic DNA. Translation: AAW71193.1.
RefSeqiWP_011256803.1. NC_006833.1.

Genome annotation databases

EnsemblBacteriaiAAW71193; AAW71193; Wbm0605.
KEGGiwbm:Wbm0605.

Similar proteinsi

Entry informationi

Entry nameiSYL_WOLTR
AccessioniPrimary (citable) accession number: Q5GS31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2005
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families