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Q5GS31

- SYL_WOLTR

UniProt

Q5GS31 - SYL_WOLTR

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Protein

Leucine--tRNA ligase

Gene
leuS, Wbm0605
Organism
Wolbachia sp. subsp. Brugia malayi (strain TRS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei611 – 6111ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWEND292805:GH18-700-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Wbm0605
OrganismiWolbachia sp. subsp. Brugia malayi (strain TRS)
Taxonomic identifieri292805 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000000534: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 865865Leucine--tRNA ligaseUniRule annotationPRO_1000009464Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292805.Wbm0605.

Structurei

3D structure databases

ProteinModelPortaliQ5GS31.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionUniRule annotationAdd
BLAST
Motifi608 – 6125"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 2 hits.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5GS31-1 [UniParc]FASTAAdd to Basket

« Hide

MKYDFKNVEK FYQDRWDFSI GKNNEQGKCY VLEMFPYPSG KIHMGHLRNY    50
VIGDVIARYK RACGFEVLHP IGWDAFGLPA ENAARDNNVN PAAWTKENID 100
NMRAQLKSIG LSYNWERELS TCEADYYKHE QKFFLDFLKQ GLVYRKKSWV 150
NWDPIDQTVL ANEQVVDGKG WRSGAIVEKR ELSQWFLKIT DFAEDLLECL 200
QGLENWPEKV KMMQDRWIGK SEGVTIEFKI VGLNKKLKVF TTCPHTLFGA 250
SFCAVAIEHP IVQDLMSKEI QDLISSIKIQ GKNNEKVGIY TGLNVKHPFL 300
DKELPLYVAN FVLMEYREGA IFGCPAHDQR DFEFAQEYDL PIIPVISSAR 350
LGIIPACDQG SYTGSQCQAT RMADGLNEEY TNNSIMFNSE FLNGLTVSEA 400
RKVIVEKLEE KGIGKKTINY RLHDWGVSRQ RYWGCPIPVI YCKNCGTVPV 450
PEEDLPVTLP TDVDFTSGGN PLDKHPTWKF VNCPKCKEQA ERETDTFDTF 500
FESSWYFAAF CSENKSIDKN ACNRFMPVDY YIGGIEHAIL HLLYSRFFCR 550
ALTKCGYFNV KEPFSTLITQ GMVCHVTYKD KNGKWLFPEE AKRLITQGAK 600
IQVGKVEKMS KSKKNTVDPN FIIEKYGADT ARLFVLSDTP PEKDMEWSND 650
GVEGCSRYIN KLWRMVMQFK PVVILNQSPV KQVADTEIQK EDMLSHAGMI 700
PDKNVTGKFL GYRKKIHKLL HGLTDDLENC RLNCVVAKFR EMTNLIAEID 750
VKTGKSLINE GICILIRVVE PFIPHLAESL WREIGGEGML YLQPWPKAAK 800
SLLIDDVVTV AVQINGKLRA TIEVAINLHQ EELKQIAINS VSNRVDQSKV 850
RAVYAVSNKI VNIVT 865
Length:865
Mass (Da):98,820
Last modified:March 1, 2005 - v1
Checksum:iCACA7BBB8CECF813
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017321 Genomic DNA. Translation: AAW71193.1.
RefSeqiWP_011256803.1. NC_006833.1.
YP_198435.1. NC_006833.1.

Genome annotation databases

EnsemblBacteriaiAAW71193; AAW71193; Wbm0605.
GeneIDi3266996.
KEGGiwbm:Wbm0605.
PATRICi24033241. VBIWolEnd7741_0986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017321 Genomic DNA. Translation: AAW71193.1 .
RefSeqi WP_011256803.1. NC_006833.1.
YP_198435.1. NC_006833.1.

3D structure databases

ProteinModelPortali Q5GS31.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292805.Wbm0605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW71193 ; AAW71193 ; Wbm0605 .
GeneIDi 3266996.
KEGGi wbm:Wbm0605.
PATRICi 24033241. VBIWolEnd7741_0986.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci WEND292805:GH18-700-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 2 hits.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TRS.

Entry informationi

Entry nameiSYL_WOLTR
AccessioniPrimary (citable) accession number: Q5GS31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2005
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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