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Q5GS31

- SYL_WOLTR

UniProt

Q5GS31 - SYL_WOLTR

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolbachia sp. subsp. Brugia malayi (strain TRS)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei611 – 6111ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciWEND292805:GH18-700-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Wbm0605
    OrganismiWolbachia sp. subsp. Brugia malayi (strain TRS)
    Taxonomic identifieri292805 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
    ProteomesiUP000000534: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 865865Leucine--tRNA ligasePRO_1000009464Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi292805.Wbm0605.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5GS31.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi608 – 6125"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 2 hits.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5GS31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYDFKNVEK FYQDRWDFSI GKNNEQGKCY VLEMFPYPSG KIHMGHLRNY    50
    VIGDVIARYK RACGFEVLHP IGWDAFGLPA ENAARDNNVN PAAWTKENID 100
    NMRAQLKSIG LSYNWERELS TCEADYYKHE QKFFLDFLKQ GLVYRKKSWV 150
    NWDPIDQTVL ANEQVVDGKG WRSGAIVEKR ELSQWFLKIT DFAEDLLECL 200
    QGLENWPEKV KMMQDRWIGK SEGVTIEFKI VGLNKKLKVF TTCPHTLFGA 250
    SFCAVAIEHP IVQDLMSKEI QDLISSIKIQ GKNNEKVGIY TGLNVKHPFL 300
    DKELPLYVAN FVLMEYREGA IFGCPAHDQR DFEFAQEYDL PIIPVISSAR 350
    LGIIPACDQG SYTGSQCQAT RMADGLNEEY TNNSIMFNSE FLNGLTVSEA 400
    RKVIVEKLEE KGIGKKTINY RLHDWGVSRQ RYWGCPIPVI YCKNCGTVPV 450
    PEEDLPVTLP TDVDFTSGGN PLDKHPTWKF VNCPKCKEQA ERETDTFDTF 500
    FESSWYFAAF CSENKSIDKN ACNRFMPVDY YIGGIEHAIL HLLYSRFFCR 550
    ALTKCGYFNV KEPFSTLITQ GMVCHVTYKD KNGKWLFPEE AKRLITQGAK 600
    IQVGKVEKMS KSKKNTVDPN FIIEKYGADT ARLFVLSDTP PEKDMEWSND 650
    GVEGCSRYIN KLWRMVMQFK PVVILNQSPV KQVADTEIQK EDMLSHAGMI 700
    PDKNVTGKFL GYRKKIHKLL HGLTDDLENC RLNCVVAKFR EMTNLIAEID 750
    VKTGKSLINE GICILIRVVE PFIPHLAESL WREIGGEGML YLQPWPKAAK 800
    SLLIDDVVTV AVQINGKLRA TIEVAINLHQ EELKQIAINS VSNRVDQSKV 850
    RAVYAVSNKI VNIVT 865
    Length:865
    Mass (Da):98,820
    Last modified:March 1, 2005 - v1
    Checksum:iCACA7BBB8CECF813
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017321 Genomic DNA. Translation: AAW71193.1.
    RefSeqiWP_011256803.1. NC_006833.1.
    YP_198435.1. NC_006833.1.

    Genome annotation databases

    EnsemblBacteriaiAAW71193; AAW71193; Wbm0605.
    GeneIDi3266996.
    KEGGiwbm:Wbm0605.
    PATRICi24033241. VBIWolEnd7741_0986.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017321 Genomic DNA. Translation: AAW71193.1 .
    RefSeqi WP_011256803.1. NC_006833.1.
    YP_198435.1. NC_006833.1.

    3D structure databases

    ProteinModelPortali Q5GS31.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292805.Wbm0605.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW71193 ; AAW71193 ; Wbm0605 .
    GeneIDi 3266996.
    KEGGi wbm:Wbm0605.
    PATRICi 24033241. VBIWolEnd7741_0986.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci WEND292805:GH18-700-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 2 hits.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TRS.

    Entry informationi

    Entry nameiSYL_WOLTR
    AccessioniPrimary (citable) accession number: Q5GS31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3