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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Wolbachia sp. subsp. Brugia malayi (strain TRS)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371SubstrateUniRule annotation
Binding sitei118 – 1181SubstrateUniRule annotation
Binding sitei151 – 1511SubstrateUniRule annotation
Binding sitei201 – 2011ATPUniRule annotation
Binding sitei322 – 3221ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi352 – 3554ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWEND292805:GH18-793-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Wbm0684
OrganismiWolbachia sp. subsp. Brugia malayi (strain TRS)
Taxonomic identifieri292805 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000000534 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Phosphoglycerate kinasePRO_1000096392Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi292805.Wbm0684.

Structurei

3D structure databases

ProteinModelPortaliQ5GRV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 243Substrate bindingUniRule annotation
Regioni60 – 634Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5GRV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNIPNIENC DLHGKAVLLR VDFNIPIKNG KVHDATRVLR SLPTIRHLVN
60 70 80 90 100
AGAKVIIISH FGRPRAKDNN LSLKNVVKTL SQLLNKEVKF VDDCIGKKVQ
110 120 130 140 150
KVVNAIAIRD VILLENLRFY KEEEQNDANF AKQLASLADV YVNDAFSCSH
160 170 180 190 200
RAHASISRIT EFLPSYAGFC LQDELRYLEK AVSFEAKPIT AIVGGAKIST
210 220 230 240 250
KIKMLIRLAE KVDYLVLGGA IANNFLLFNK VNIGKSFFQN GVDSLLHDVV
260 270 280 290 300
KIADKNNCKI VIPEDVLIAV NSDYSTCILR KTESVLDNDV ILDIGPQTLS
310 320 330 340 350
TISSIVASSK ALLWNGPIGV FEHSAFANGT IEVMKVVSDS THKGKLTSVI
360 370 380 390
GGGDSLSAIN AAGLTDKDFT YVSTGGGAFL SWLSGDKMPG IAALQSMLN
Length:399
Mass (Da):43,398
Last modified:March 1, 2005 - v1
Checksum:i890AE5E64AC2D999
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017321 Genomic DNA. Translation: AAW71272.1.
RefSeqiWP_011256881.1. NC_006833.1.

Genome annotation databases

EnsemblBacteriaiAAW71272; AAW71272; Wbm0684.
KEGGiwbm:Wbm0684.
PATRICi24033507. VBIWolEnd7741_1112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017321 Genomic DNA. Translation: AAW71272.1.
RefSeqiWP_011256881.1. NC_006833.1.

3D structure databases

ProteinModelPortaliQ5GRV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi292805.Wbm0684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW71272; AAW71272; Wbm0684.
KEGGiwbm:Wbm0684.
PATRICi24033507. VBIWolEnd7741_1112.

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BioCyciWEND292805:GH18-793-MONOMER.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TRS.

Entry informationi

Entry nameiPGK_WOLTR
AccessioniPrimary (citable) accession number: Q5GRV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 1, 2005
Last modified: July 22, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.