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Q5GRR7 (HEMH_WOLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Wbm0719
OrganismWolbachia sp. subsp. Brugia malayi (strain TRS) [Complete proteome] [HAMAP]
Taxonomic identifier292805 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachieae › Wolbachia

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Ferrochelatase HAMAP MF_00323
PRO_1000019384

Sites

Metal binding2181Iron By similarity
Metal binding2981Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5GRR7 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: B2C414A36359B95D

FASTA34038,928
        10         20         30         40         50         60 
MKKAVVLLNL GGPDSLSAVR PFLFNLFYDK RIINLPNPFR FFLAKFISAK RENNARKIYE 

        70         80         90        100        110        120 
QIGGKSPILE NTKMQAEALE RELNRSVFCH PSSVTLGPRK ENWIPVSRIG MTSKLTKVFI 

       130        140        150        160        170        180 
CMRYWHPFAN EVVKSVKQFD PDEVILLPLY PQYSTTTTLS SIENWQKNAK QYGIKCNTKI 

       190        200        210        220        230        240 
IRHHYDNQDF IEAHANLITK HYKLASEVGK PRVLFSAHSL PLSVIKKGDP YALQVEETVK 

       250        260        270        280        290        300 
LIVKKLHIKD LDWSICYQSK IGPVKWLEPS TESELLRAKA DGVPVVLLPI SFVSEHSETL 

       310        320        330        340 
VELDMEYKTI IKDGYYFRIP TLSTNSLFIK CLAGLCINHS

« Hide

References

[1]"The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode."
Foster J., Ganatra M., Kamal I., Ware J., Makarova K., Ivanova N., Bhattacharyya A., Kapatral V., Kumar S., Posfai J., Vincze T., Ingram J., Moran L., Lapidus A., Omelchenko M., Kyrpides N., Ghedin E., Wang S. expand/collapse author list , Goltsman E., Joukov V., Ostrovskaya O., Tsukerman K., Mazur M., Comb D., Koonin E., Slatko B.
PLoS Biol. 3:599-614(2005) [PubMed: 15780005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TRS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017321 Genomic DNA. Translation: AAW71307.1.
RefSeqYP_198549.1. NC_006833.1.

3D structure databases

HSSPHSSP built from PDB template 1HRK based on UniProtKB P22830.
ProteinModelPortalQ5GRR7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5GRR7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBWOLT00000002761; EBWOLP00000002456; EBWOLG00000002761.
GeneID3266378.
GenomeReviewsGene locus Wbm0719 in contig AE017321_GR.
KEGGwbm:Wbm0719.
PATRIC24033639. VBIWolEnd7741_1174.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
GeneTreeEBGT00050000031382.
HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBQ5GRR7.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycWPIP80849:WBM0719-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_WOLTR
AccessionPrimary (citable) accession number: Q5GRR7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2005
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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