Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5GRJ9

- PYRF_WOLTR

UniProt

Q5GRJ9 - PYRF_WOLTR

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Wolbachia sp. subsp. Brugia malayi (strain TRS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91SubstrateUniRule annotation
    Binding sitei31 – 311SubstrateUniRule annotation
    Active sitei60 – 601Proton donorUniRule annotation
    Binding sitei115 – 1151SubstrateUniRule annotation
    Binding sitei176 – 1761SubstrateUniRule annotation
    Binding sitei184 – 1841SubstrateUniRule annotation
    Binding sitei204 – 2041Substrate; via amide nitrogenUniRule annotation
    Binding sitei205 – 2051SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciWEND292805:GH18-914-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:Wbm0787
    OrganismiWolbachia sp. subsp. Brugia malayi (strain TRS)
    Taxonomic identifieri292805 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
    ProteomesiUP000000534: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225Orotidine 5'-phosphate decarboxylasePRO_0000241929Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi292805.Wbm0787.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5GRJ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 6710Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226071.
    KOiK01591.
    OMAiHAKEPRE.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5GRJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPIICALDT QDLNEAISLA NTLRDKVGMI KLGLEFFAAH GPSGVREVAK    50
    CNVPTFLDLK LHDIPNTVAK TVEAIKVLNI EILTLHISGG TKMLEEALSI 100
    VKDTKTKLIG VTVLTSMSNE DLSELGIARE VKSQVILFAK LAKKVGLHGI 150
    VCSALEAQEV YQECGKDFKI ITSGIRVGFG HDDQKRTATP KEAINSGADY 200
    IVIGRPITKS NSPANSAELI LKSLS 225
    Length:225
    Mass (Da):24,192
    Last modified:March 1, 2005 - v1
    Checksum:iE5BCA1A46A02238F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017321 Genomic DNA. Translation: AAW71375.1.
    RefSeqiYP_198617.1. NC_006833.1.

    Genome annotation databases

    EnsemblBacteriaiAAW71375; AAW71375; Wbm0787.
    GeneIDi3266717.
    KEGGiwbm:Wbm0787.
    PATRICi24033875. VBIWolEnd7741_1290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017321 Genomic DNA. Translation: AAW71375.1 .
    RefSeqi YP_198617.1. NC_006833.1.

    3D structure databases

    ProteinModelPortali Q5GRJ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292805.Wbm0787.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW71375 ; AAW71375 ; Wbm0787 .
    GeneIDi 3266717.
    KEGGi wbm:Wbm0787.
    PATRICi 24033875. VBIWolEnd7741_1290.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226071.
    KOi K01591.
    OMAi HAKEPRE.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci WEND292805:GH18-914-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TRS.

    Entry informationi

    Entry nameiPYRF_WOLTR
    AccessioniPrimary (citable) accession number: Q5GRJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3