Reviewed, UniProtKB/Swiss-Prot Q5GQ85 (ARGR1_ARGRF)

Names and origin

Protein names	Recommended name:     Allergen Arg r 1 Alternative name(s):     Allergen=Arg r 1
Organism	Argas reflexus (European pigeon tick)
Taxonomic identifier	34604 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Argasidae › Argasinae › Argas

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted.
Post-translational modification	Not glycosylated. Ref.1
Allergenic properties	Causes an allergic reaction in human. Binds to IgE. Major allergen responsible for anaphylactic reactions. Ref.1
Sequence similarities	Belongs to the calycin superfamily. Histamine-binding salivary protein family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Ref.1 Ref.2
	Chain	17 – 159	143	Allergen Arg r 1		PRO_5000072608
Amino acid modifications
	Disulfide bond	50 ↔ 155		By similarity
	Disulfide bond	109 ↔ 134		By similarity
Experimental info
	Sequence conflict	19	1	C → E AA sequence Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q5GQ85-1 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: BCA1BD9C6F9CB77C	FASTA	159	16,965
	10 20 30 40 50 60 MALIILLVAC LSVVSADDCS GKTDAWTSIK GPKTGGYWLK QTTKTGENEC TYVKGTDFKE 70 80 90 100 110 120 NTKTATYTYG YKDASGKLTK TTGTATAKGS DIVVGSDTST VIYTDGKTCD VVKHGGHTEL 130 140 150 WVHSSKTSGG YNNCCDKKFT ETRGSTPANE VYKKCPGMP

References

[1]	"IgE-mediated anaphylaxis caused by bites of the pigeon tick Argas reflexus: cloning and expression of the major allergen Arg r 1." Hilger C., Bessot J.-C., Hutt N., Grigioni F., de Blay F., Pauli G., Hentges F. J. Allergy Clin. Immunol. 115:617-622(2005) [PubMed: 15753913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 17-30, LACK OF GLYCOSYLATION, ALLERGENICITY.
[2]	Hilger C. Submitted (SEP-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 17-31, SEQUENCE REVISION TO 18 AND 26.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ697694 mRNA. Translation: CAG26895.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR011038. Calycin-like. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGR1_ARGRF

Accession

Primary (citable) accession number: Q5GQ85

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2005
Last modified:	November 24, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)