Q5GQ85 (ARGR1_ARGRF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Allergen Arg r 1 Alternative name(s): Allergen=Arg r 1
Organism	Argas reflexus (European pigeon tick)
Taxonomic identifier	34604 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Argasidae › Argasinae › Argas

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Post-translational modification	Not glycosylated. Ref.1
Allergenic properties	Causes an allergic reaction in human. Binds to IgE. Major allergen responsible for anaphylactic reactions. Ref.1
Sequence similarities	Belongs to the calycin superfamily. Histamine-binding salivary protein family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
PTM	Disulfide bond
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 16

16

Ref.1 Ref.2

Chain

17 – 159

143

Allergen Arg r 1

PRO_5000072608

Amino acid modifications

Disulfide bond

50 ↔ 155

By similarity

Disulfide bond

109 ↔ 134

By similarity

Experimental info

Sequence conflict

19

1

C → E AA sequence Ref.1

Secondary structure

1

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159

Helix Strand Turn

Details...

Helix

25 – 29

5

Beta strand

38 – 43

6

Turn

60 – 63

4

Beta strand

78 – 81

4

Beta strand

85 – 87

3

Beta strand

91 – 93

3

Beta strand

98 – 104

7

Beta strand

109 – 113

5

Beta strand

118 – 122

5

Helix

124 – 126

3

Helix

135 – 142

8

Sequences

	Sequence		Length	Mass (Da)
	Q5GQ85 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: BCA1BD9C6F9CB77C	FASTA	159	16,965
	10 20 30 40 50 60 MALIILLVAC LSVVSADDCS GKTDAWTSIK GPKTGGYWLK QTTKTGENEC TYVKGTDFKE 70 80 90 100 110 120 NTKTATYTYG YKDASGKLTK TTGTATAKGS DIVVGSDTST VIYTDGKTCD VVKHGGHTEL 130 140 150 WVHSSKTSGG YNNCCDKKFT ETRGSTPANE VYKKCPGMP

References

[1]	"IgE-mediated anaphylaxis caused by bites of the pigeon tick Argas reflexus: cloning and expression of the major allergen Arg r 1." Hilger C., Bessot J.-C., Hutt N., Grigioni F., de Blay F., Pauli G., Hentges F. J. Allergy Clin. Immunol. 115:617-622(2005) [PubMed: 15753913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 17-30, LACK OF GLYCOSYLATION, ALLERGEN.
[2]	Hilger C. Submitted (SEP-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 17-31, SEQUENCE REVISION TO 18 AND 26.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ697694 mRNA. Translation: CAG26895.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2X45	X-ray	1.40	A/B/C	17-159	[»]
2X46	X-ray	1.00	A	17-159	[»]

ProteinModelPortal

Q5GQ85.

ModBase

Search...

Protein family/group databases

Allergome

1150. Arg r 1.
3101. Arg r 1.0101.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR012674. Calycin.
IPR011038. Calycin-like.
[Graphical view]

Gene3D

G3DSA:2.40.128.20. Calycin. 1 hit.

SUPFAM

SSF50814. Calycin. 1 hit.

ProtoNet

Search...

Entry information

Entry name

ARGR1_ARGRF

Accession

Primary (citable) accession number: Q5GQ85

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2005
Last modified:	September 21, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)