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Q5GM68

- CAPP2_ARATH

UniProt

Q5GM68 - CAPP2_ARATH

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Protein
Phosphoenolpyruvate carboxylase 2
Gene
PPC2, At2g42600, F14N22.13
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

By light-reversible phosphorylation By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei172 – 1721 By similarity
Active sitei599 – 5991 By similarity

GO - Molecular functioni

  1. phosphoenolpyruvate carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbon fixation Source: UniProtKB-KW
  2. photosynthesis Source: UniProtKB-KW
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation, Photosynthesis

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciARA:GQT-2357-MONOMER.
BRENDAi4.1.1.31. 399.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase 2 (EC:4.1.1.31)
Short name:
AtPPC2
Short name:
PEPC 2
Short name:
PEPCase 2
Gene namesi
Name:PPC2
Ordered Locus Names:At2g42600
ORF Names:F14N22.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G42600.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. apoplast Source: TAIR
  2. chloroplast Source: TAIR
  3. cytosol Source: TAIR
  4. plasma membrane Source: TAIR
  5. plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Phosphoenolpyruvate carboxylase 2UniRule annotation
PRO_0000166658Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111Phosphoserine By similarity
Modified residuei701 – 7011Phosphoserine1 Publication

Post-translational modificationi

Ubiquitinated.UniRule annotation

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5GM68.
PRIDEiQ5GM68.

Expressioni

Tissue specificityi

Expressed in all plant organs, with higher levels in stems and leaves.1 Publication

Gene expression databases

ArrayExpressiQ5GM68.
GenevestigatoriQ5GM68.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

BioGridi4197. 2 interactions.
STRINGi3702.AT2G42600.2-P.

Structurei

3D structure databases

ProteinModelPortaliQ5GM68.
SMRiQ5GM68. Positions 6-963.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
InParanoidiQ5GM68.
KOiK01595.
OMAiYNAPIIQ.
PhylomeDBiQ5GM68.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5GM68-1 [UniParc]FASTAAdd to Basket

« Hide

MAARNLEKMA SIDAQLRLLA PGKVSEDDKL IEYDALLLDR FLDILQDLHG    50
EDVREFVQEC YEVAADYDGN RNTEKLEELG NMLTSLDPGD SIVVTKSFSN 100
MLSLANLAEE VQIAYRRRIK KLKKGDFADE ASATTESDIE ETLKRLLQLN 150
KTPEEVFDAL KNQTVDLVLT AHPTQSVRRS LLQKFGRIRD CLTQLYAKDI 200
TPDDKQELDE ALQREIQAAF RTDEIRRTPP TPQDEMRAGM SYFHETIWKG 250
VPKFLRRVDT ALKNIGINER VPYNAPLIQF SSWMGGDRDG NPRVTPEVTR 300
DVCLLARMMA ANLYFSQIED LMFEMSMWRC NEELRVRAER QRCAKRDAKH 350
YIEFWKQIPA NEPYRAILGD VRDKLYNTRE RARQLLSSGV SDVPEDAVFT 400
SVDQFLEPLE LCYRSLCDCG DRPIADGSLL DFLRQVSTFG LALVKLDIRQ 450
ESERHSDVLD AITTHLGIGS YKEWSEDKRQ EWLLSELSGK RPLFGPDLPK 500
TEEVADVLDT FKVISELPSD SFGAYIISMA TAPSDVLAVE LLQRECGITD 550
PLRVVPLFEK LADLESAPAA VARLFSIEWY RNRINGKQEV MIGYSDSGKD 600
AGRLSAAWQL YKTQEELVKV AKEYGVKLTM FHGRGGTVGR GGGPTHLAIL 650
SQPPDTIHGQ LRVTVQGEVI EQSFGEEHLC FRTLQRFTAA TLEHGMHPPV 700
SPKPEWRVLM DEMAIIATEE YRSVVFKEPR FVEYFRLATP ELEYGRMNIG 750
SRPSKRKPSG GIESLRAIPW IFAWTQTRFH LPVWLGFGGA FKRVIQKDSK 800
NLNMLKEMYN QWPFFRVTID LVEMVFAKGD PGIAALYDRL LVSEELQPFG 850
EQLRVNYQET RRLLLQVAGH KDILEGDPYL RQRLQLRDPY ITTLNVCQAY 900
TLKQIRDPSF HVKVRPHLSK DYMESSPAAE LVKLNPKSEY APGLEDTVIL 950
TMKGIAAGMQ NTG 963
Length:963
Mass (Da):109,753
Last modified:August 30, 2005 - v2
Checksum:iD2F000BC8087D845
GO

Sequence cautioni

The sequence AAD22994.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti453 – 4531E → D in AAP43628. 1 Publication
Sequence conflicti456 – 4561S → T in AAP43628. 1 Publication
Sequence conflicti770 – 7701W → R in CAD58726. 1 Publication
Sequence conflicti799 – 7991S → N in AAP43628. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ532902 mRNA. Translation: CAD58726.1.
AY210895 mRNA. Translation: AAP43628.1.
AC007087 Genomic DNA. Translation: AAD22994.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC10145.1.
CP002685 Genomic DNA. Translation: AEC10146.1.
PIRiH84855.
RefSeqiNP_850372.4. NM_180041.4.
NP_850373.4. NM_180042.5.
UniGeneiAt.14366.

Genome annotation databases

EnsemblPlantsiAT2G42600.1; AT2G42600.1; AT2G42600.
AT2G42600.2; AT2G42600.2; AT2G42600.
GeneIDi818860.
KEGGiath:AT2G42600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ532902 mRNA. Translation: CAD58726.1 .
AY210895 mRNA. Translation: AAP43628.1 .
AC007087 Genomic DNA. Translation: AAD22994.1 . Sequence problems.
CP002685 Genomic DNA. Translation: AEC10145.1 .
CP002685 Genomic DNA. Translation: AEC10146.1 .
PIRi H84855.
RefSeqi NP_850372.4. NM_180041.4.
NP_850373.4. NM_180042.5.
UniGenei At.14366.

3D structure databases

ProteinModelPortali Q5GM68.
SMRi Q5GM68. Positions 6-963.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 4197. 2 interactions.
STRINGi 3702.AT2G42600.2-P.

Proteomic databases

PaxDbi Q5GM68.
PRIDEi Q5GM68.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G42600.1 ; AT2G42600.1 ; AT2G42600 .
AT2G42600.2 ; AT2G42600.2 ; AT2G42600 .
GeneIDi 818860.
KEGGi ath:AT2G42600.

Organism-specific databases

GeneFarmi 5061. 479.
TAIRi AT2G42600.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238648.
InParanoidi Q5GM68.
KOi K01595.
OMAi YNAPIIQ.
PhylomeDBi Q5GM68.

Enzyme and pathway databases

BioCyci ARA:GQT-2357-MONOMER.
BRENDAi 4.1.1.31. 399.

Gene expression databases

ArrayExpressi Q5GM68.
Genevestigatori Q5GM68.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and expression analysis of a gene encoding a bacterial-type phosphoenolpyruvate carboxylase from Arabidopsis and rice."
    Sanchez R., Cejudo F.J.
    Plant Physiol. 132:949-957(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Cloning of Arabidopsis guard cell PEP carboxylase."
    Zanor M.I., Plesch G., Mueller-Roeber B.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-701, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Root.
  6. "Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis."
    Saracco S.A., Hansson M., Scalf M., Walker J.M., Smith L.M., Vierstra R.D.
    Plant J. 59:344-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCAPP2_ARATH
AccessioniPrimary (citable) accession number: Q5GM68
Secondary accession number(s): Q8GVE9, Q9SIN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi