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Protein

Tumor necrosis factor alpha-induced protein 8-like protein 3

Gene

TNFAIP8L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.By similarity

Caution

It is uncertain whether Met-1 or Met-89 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1483255 PI Metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8-like protein 3
Short name:
TNF alpha-induced protein 8-like protein 3
Short name:
TNFAIP8-like protein 3
Gene namesi
Name:TNFAIP8L3
Synonyms:TIPE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000183578.5
HGNCiHGNC:20620 TNFAIP8L3
MIMi616438 gene
neXtProtiNX_Q5GJ75

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi388121
OpenTargetsiENSG00000183578
PharmGKBiPA142670724

Polymorphism and mutation databases

BioMutaiTNFAIP8L3
DMDMi74707829

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314241 – 292Tumor necrosis factor alpha-induced protein 8-like protein 3Add BLAST292

Proteomic databases

EPDiQ5GJ75
PaxDbiQ5GJ75
PeptideAtlasiQ5GJ75
PRIDEiQ5GJ75

PTM databases

iPTMnetiQ5GJ75
PhosphoSitePlusiQ5GJ75

Expressioni

Tissue specificityi

Widely expressed (at protein level) (PubMed:25479791). Highly expressed in most carcinoma cell lines (PubMed:25479791, PubMed:25242044).2 Publications

Gene expression databases

BgeeiENSG00000183578
CleanExiHS_TNFAIP8L3
ExpressionAtlasiQ5GJ75 baseline and differential

Organism-specific databases

HPAiHPA048372

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBPO005604EBI-14222571,EBI-727004

Protein-protein interaction databases

IntActiQ5GJ75, 2 interactors

Structurei

Secondary structure

1292
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi112 – 135Combined sources24
Helixi139 – 156Combined sources18
Helixi159 – 181Combined sources23
Helixi187 – 212Combined sources26
Helixi214 – 216Combined sources3
Helixi219 – 237Combined sources19
Helixi245 – 257Combined sources13
Helixi259 – 266Combined sources8
Helixi273 – 288Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q9VX-ray2.30A/B109-292[»]
ProteinModelPortaliQ5GJ75
SMRiQ5GJ75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 292Binding to phosphoinositidesBy similarityAdd BLAST184

Sequence similaritiesi

Belongs to the TNFAIP8 family.Curated

Phylogenomic databases

eggNOGiENOG410IE5H Eukaryota
ENOG4111HNU LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
HOVERGENiHBG053286
InParanoidiQ5GJ75
OMAiAMTMVSF
OrthoDBiEOG091G0QQ9
PhylomeDBiQ5GJ75
TreeFamiTF323415

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit

Sequencei

Sequence statusi: Complete.

Q5GJ75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKPRQNPST LVSTLCEAEP KGKLWVNGYA GTQGTRDATL QTRLIPLSFH
60 70 80 90 100
LQRGKGLAAP LSALSAPRLP ERPADGRVAV DAQPAARSMD SDSGEQSEGE
110 120 130 140 150
PVTAAGPDVF SSKSLALQAQ KKILSKIASK TVANMLIDDT SSEIFDELYK
160 170 180 190 200
VTKEHTHNKK EAHKIMKDLI KVAIKIGILY RNNQFSQEEL VIVEKFRKKL
210 220 230 240 250
NQTAMTIVSF YEVEYTFDRN VLSNLLHECK DLVHELVQRH LTPRTHGRIN
260 270 280 290
HVFNHFADVE FLSTLYSLDG DCRPNLKRIC EGINKLLDEK VL
Length:292
Mass (Da):32,659
Last modified:March 1, 2005 - v1
Checksum:i438700088C3DA6E3
GO

Sequence cautioni

The sequence AAI27702 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI27703 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC85572 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW77412 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04286038A → T. Corresponds to variant dbSNP:rs17647084Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY517501 mRNA Translation: AAS76642.1
AK123281 mRNA Translation: BAC85572.1 Different initiation.
CH471082 Genomic DNA Translation: EAW77412.1 Sequence problems.
BC127701 mRNA Translation: AAI27702.1 Different initiation.
BC127702 mRNA Translation: AAI27703.1 Different initiation.
CCDSiCCDS32241.1
RefSeqiNP_001298104.1, NM_001311175.1
NP_997264.2, NM_207381.3
UniGeneiHs.306343

Genome annotation databases

EnsembliENST00000327536; ENSP00000328016; ENSG00000183578
GeneIDi388121
KEGGihsa:388121
UCSCiuc001zyy.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTP8L3_HUMAN
AccessioniPrimary (citable) accession number: Q5GJ75
Secondary accession number(s): Q6ZWD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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