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Protein

Tumor necrosis factor alpha-induced protein 8-like protein 3

Gene

TNFAIP8L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8-like protein 3
Short name:
TNF alpha-induced protein 8-like protein 3
Short name:
TNFAIP8-like protein 3
Gene namesi
Name:TNFAIP8L3
Synonyms:TIPE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:20620. TNFAIP8L3.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell membrane By similarity

  • Note: On PDGF activation, translocates from cytoplasm to plasma membrane.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670724.

Polymorphism and mutation databases

BioMutaiTNFAIP8L3.
DMDMi74707829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Tumor necrosis factor alpha-induced protein 8-like protein 3PRO_0000331424Add
BLAST

Proteomic databases

PaxDbiQ5GJ75.
PRIDEiQ5GJ75.

PTM databases

PhosphoSiteiQ5GJ75.

Expressioni

Tissue specificityi

Widely expressed (at protein level) (PubMed:25479791). Highly expressed in most carcinoma cell lines (PubMed:25479791, PubMed:25242044).2 Publications

Gene expression databases

BgeeiQ5GJ75.
CleanExiHS_TNFAIP8L3.

Organism-specific databases

HPAiHPA048372.

Structurei

Secondary structure

1
292
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi112 – 13524Combined sources
Helixi139 – 15618Combined sources
Helixi159 – 18123Combined sources
Helixi187 – 21226Combined sources
Helixi214 – 2163Combined sources
Helixi219 – 23719Combined sources
Helixi245 – 25713Combined sources
Helixi259 – 2668Combined sources
Helixi273 – 28816Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q9VX-ray2.30A/B109-292[»]
ProteinModelPortaliQ5GJ75.
SMRiQ5GJ75. Positions 109-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 292184Binding to phosphoinositidesBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the TNFAIP8 family.Curated

Phylogenomic databases

eggNOGiENOG410IE5H. Eukaryota.
ENOG4111HNU. LUCA.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiQ5GJ75.
OMAiMVSFYEV.
OrthoDBiEOG7P5T2H.
PhylomeDBiQ5GJ75.
TreeFamiTF323415.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PANTHERiPTHR12757. PTHR12757. 1 hit.
PfamiPF05527. DUF758. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5GJ75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKPRQNPST LVSTLCEAEP KGKLWVNGYA GTQGTRDATL QTRLIPLSFH
60 70 80 90 100
LQRGKGLAAP LSALSAPRLP ERPADGRVAV DAQPAARSMD SDSGEQSEGE
110 120 130 140 150
PVTAAGPDVF SSKSLALQAQ KKILSKIASK TVANMLIDDT SSEIFDELYK
160 170 180 190 200
VTKEHTHNKK EAHKIMKDLI KVAIKIGILY RNNQFSQEEL VIVEKFRKKL
210 220 230 240 250
NQTAMTIVSF YEVEYTFDRN VLSNLLHECK DLVHELVQRH LTPRTHGRIN
260 270 280 290
HVFNHFADVE FLSTLYSLDG DCRPNLKRIC EGINKLLDEK VL
Length:292
Mass (Da):32,659
Last modified:March 1, 2005 - v1
Checksum:i438700088C3DA6E3
GO

Sequence cautioni

The sequence AAI27702.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI27703.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC85572.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAW77412.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381A → T.
Corresponds to variant rs17647084 [ dbSNP | Ensembl ].
VAR_042860

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY517501 mRNA. Translation: AAS76642.1.
AK123281 mRNA. Translation: BAC85572.1. Different initiation.
CH471082 Genomic DNA. Translation: EAW77412.1. Sequence problems.
BC127701 mRNA. Translation: AAI27702.1. Different initiation.
BC127702 mRNA. Translation: AAI27703.1. Different initiation.
CCDSiCCDS32241.1.
RefSeqiNP_001298104.1. NM_001311175.1.
NP_997264.2. NM_207381.3.
UniGeneiHs.306343.

Genome annotation databases

EnsembliENST00000327536; ENSP00000328016; ENSG00000183578.
GeneIDi388121.
KEGGihsa:388121.
UCSCiuc001zyy.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY517501 mRNA. Translation: AAS76642.1.
AK123281 mRNA. Translation: BAC85572.1. Different initiation.
CH471082 Genomic DNA. Translation: EAW77412.1. Sequence problems.
BC127701 mRNA. Translation: AAI27702.1. Different initiation.
BC127702 mRNA. Translation: AAI27703.1. Different initiation.
CCDSiCCDS32241.1.
RefSeqiNP_001298104.1. NM_001311175.1.
NP_997264.2. NM_207381.3.
UniGeneiHs.306343.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q9VX-ray2.30A/B109-292[»]
ProteinModelPortaliQ5GJ75.
SMRiQ5GJ75. Positions 109-292.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ5GJ75.

Polymorphism and mutation databases

BioMutaiTNFAIP8L3.
DMDMi74707829.

Proteomic databases

PaxDbiQ5GJ75.
PRIDEiQ5GJ75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327536; ENSP00000328016; ENSG00000183578.
GeneIDi388121.
KEGGihsa:388121.
UCSCiuc001zyy.5. human.

Organism-specific databases

CTDi388121.
GeneCardsiTNFAIP8L3.
HGNCiHGNC:20620. TNFAIP8L3.
HPAiHPA048372.
MIMi616438. gene.
neXtProtiNX_Q5GJ75.
PharmGKBiPA142670724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5H. Eukaryota.
ENOG4111HNU. LUCA.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiQ5GJ75.
OMAiMVSFYEV.
OrthoDBiEOG7P5T2H.
PhylomeDBiQ5GJ75.
TreeFamiTF323415.

Miscellaneous databases

GenomeRNAii388121.
NextBioi101834.
PROiQ5GJ75.
SOURCEiSearch...

Gene expression databases

BgeeiQ5GJ75.
CleanExiHS_TNFAIP8L3.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PANTHERiPTHR12757. PTHR12757. 1 hit.
PfamiPF05527. DUF758. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Chen S., Guo J.H., Yu L.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-292.
    Tissue: Amygdala.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-292.
  5. "Identical expression profiling of human and murine TIPE3 protein reveals links to its functions."
    Cui J., Hao C., Zhang W., Shao J., Zhang N., Zhang G., Liu S.
    J. Histochem. Cytochem. 63:206-216(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  6. "TIPE3 is the transfer protein of lipid second messengers that promote cancer."
    Fayngerts S.A., Wu J., Oxley C.L., Liu X., Vourekas A., Cathopoulis T., Wang Z., Cui J., Liu S., Sun H., Lemmon M.A., Zhang L., Shi Y., Chen Y.H.
    Cancer Cell 26:465-478(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 109-292, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTP8L3_HUMAN
AccessioniPrimary (citable) accession number: Q5GJ75
Secondary accession number(s): Q6ZWD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2005
Last modified: March 16, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-89 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.