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Protein

Vascular endothelial growth factor receptor 2

Gene

kdr

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis.2 Publications

Caution

This entry should not be confused with kdrl (AC Q8AXB3), which used to be called kdr.Curated

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei877ATPPROSITE-ProRule annotation1
Active sitei1039Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi849 – 857ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: ZFIN
  • blood vessel development Source: ZFIN
  • cell differentiation Source: UniProtKB-KW
  • cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
  • vascular endothelial growth factor receptor signaling pathway Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processAngiogenesis, Differentiation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-194306 Neurophilin interactions with VEGF and VEGFR
R-DRE-195399 VEGF binds to VEGFR leading to receptor dimerization
R-DRE-216083 Integrin cell surface interactions
R-DRE-3928662 EPHB-mediated forward signaling
R-DRE-4420097 VEGFA-VEGFR2 Pathway
R-DRE-5218921 VEGFR2 mediated cell proliferation

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor receptor 2 (EC:2.7.10.1)
Short name:
VEGFR-2
Alternative name(s):
Fetal liver kinase 1b
Short name:
FLK-1b
Kinase insert domain receptor
Kinase insert domain receptor-B
Protein-tyrosine kinase receptor flk-1b
Vascular endothelial growth factor receptor 2 homolog B
Short name:
VEGFR-2 homolog B
Gene namesi
Name:kdr
Synonyms:flk1b, kdrb
ORF Names:si:busm1-205d10.1, si:ch211-254j6.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-041001-112 kdr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 774ExtracellularSequence analysisAdd BLAST752
Transmembranei775 – 795HelicalSequence analysisAdd BLAST21
Topological domaini796 – 1357CytoplasmicSequence analysisAdd BLAST562

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2331049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000024946523 – 1357Vascular endothelial growth factor receptor 2Add BLAST1335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi53 ↔ 104PROSITE-ProRule annotation
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 203PROSITE-ProRule annotation
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi248 ↔ 314PROSITE-ProRule annotation
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi457 ↔ 538PROSITE-ProRule annotation
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi579 ↔ 651PROSITE-ProRule annotation
Glycosylationi621N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi688N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi697 ↔ 746PROSITE-ProRule annotation
Glycosylationi713N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1065Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1070Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1186Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1222Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5GIT4
PRIDEiQ5GIT4

Expressioni

Tissue specificityi

First expressed in embryos between 5- and 7-somites in the bilateral stripes that contain the developing angioblasts, and then localized to the intermediate cell mass (ICM) and the developing vasculature. By 30 hpf, expressed in the major trunk, head and intersomitic vessels, persisting through 4 dpf when expression is seen in developing subintestinal veins and in the remaining vasculature.3 Publications

Developmental stagei

The first vegfr expressed during development.1 Publication

Gene expression databases

BgeeiENSDARG00000017321

Interactioni

Subunit structurei

Interacts with isoform VEGF165 of vegfaa and, to a lesser extent, with isoform VEGF171 of vegfab.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000049203

Chemistry databases

BindingDBiQ5GIT4

Structurei

3D structure databases

ProteinModelPortaliQ5GIT4
SMRiQ5GIT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 120Ig-like C2-type 1Add BLAST89
Domaini120 – 222Ig-like C2-type 2Add BLAST103
Domaini216 – 330Ig-like C2-type 3Add BLAST115
Domaini335 – 426Ig-like C2-type 4Add BLAST92
Domaini433 – 553Ig-like C2-type 5Add BLAST121
Domaini556 – 667Ig-like C2-type 6Add BLAST112
Domaini676 – 762Ig-like C2-type 7Add BLAST87
Domaini843 – 1173Protein kinasePROSITE-ProRule annotationAdd BLAST331

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000037949
HOVERGENiHBG053432
InParanoidiQ5GIT4
KOiK05098
OMAiMFFWLLL
OrthoDBiEOG091G01TL
PhylomeDBiQ5GIT4
TreeFamiTF325768

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
IPR009136 VEGFR2_rcpt
PANTHERiPTHR24416:SF45 PTHR24416:SF45, 2 hits
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 8 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5GIT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTSYALLL LDILLTFNVA KAIELRFVPD PPTLNITEKT IKINASDTLQ
60 70 80 90 100
ITCRGRQILE WSTPHNRTSS ETRLTISDCS GDGLFCSTLT LSKAVANETG
110 120 130 140 150
EYRCFYKSLP KEDGKTSVAV YVFIQDYRTP FVRIAQDYDV VFIREGEQVV
160 170 180 190 200
IPCLVSVEDL NVTLYTKYPV KELSTDGKEV IWDSRRGFIL PSRVVSYAGV
210 220 230 240 250
VYCQTTIRNE TFQSSPYIVA VVGYKIYDLT LSPQHERLTV GERLILNCTA
260 270 280 290 300
HTELNVGIDF QWTFPHEKRS VNGSMSTSRY KTSSNKKKLW NSLELSNTLT
310 320 330 340 350
VENVTLNDTG EYICTASSGQ MQKIAQASLI VYEKPFIALS DQLWQTVEAK
360 370 380 390 400
AGDAEAKILV KYYAYPEPAV RWYKNDQLIV LRDEYRMKFY RGVHLTIYGV
410 420 430 440 450
TEKDAGNYTV VMTNKITKEE QRRTFQLVVN DLPRIFEKDV SLDRDVHMYG
460 470 480 490 500
SSPTLTCTAS GGSSPVTIKW QWMPREDCPV RFLPKSDTRM AKCDKWREMS
510 520 530 540 550
NNTGKNPLIS QTSVDERTLK TISTLKIQKA VDHALYRCIA TNKMGQDQRV
560 570 580 590 600
IVFQVTRFLN LSVLPSSSPI EGQDVIMRCV ADRLLYYNLR WYRVANVANH
610 620 630 640 650
DPPPAAVPCD TLTLSHLHQP NVTVSGLQGT NVTLDMPIPN ATMMDQGLYA
660 670 680 690 700
CQVEIVGTNE KTCLLHNLRL RALEMSRIVT NLTDQRVNVS DSTTLVCEVS
710 720 730 740 750
GTPTPTIVWT KDNQTVMEGS GVILKRSNRV LTIQRVKKED SGLYICTACN
760 770 780 790 800
QQGCESSEAR ISVDGAEEKM NVELIMPIGA VVIAMFLWLL IVFVIRNRKR
810 820 830 840 850
PNDGDLKTGY LSIILDSDDM PMDEHCERLT YDASKWEFPR DRLKLGEPLG
860 870 880 890 900
RGAFGQVVEA TAYGIEKATT CTTVAVKMLK EGATSSEYRA LMSELKILIH
910 920 930 940 950
IGHHLNVVNL LGACTKQGGP LMVIVEYCKH GNLSSYLKSK RGEYSPYKKR
960 970 980 990 1000
TPRMPNRREV QQDEDPREGD LGLGTSTRLD ICTGTAVCTR TGEQTYKTLQ
1010 1020 1030 1040 1050
DEQESSDWDH LTMEDLISYS FQVAKGMEFL ASRKCIHRDL AARNILLSEN
1060 1070 1080 1090 1100
SVVKICDFGL ARDVYKDPDY VRKGDARLPL KWMAPETIFD RVYTTQSDVW
1110 1120 1130 1140 1150
SFGVLLWEIF SLGASPYPGV CIDESFCRRL KEGTRMRAPD YATPEIYQTM
1160 1170 1180 1190 1200
LDCWLDRPLD RPTFTQLVEH LGNLLQASAQ QDGKDYIPLT NGEMEEELVA
1210 1220 1230 1240 1250
PHLNVTSKRS FYAGNTEAQL HYDNAPPLGF PQQMNSSGVP VNMTGFVDIP
1260 1270 1280 1290 1300
LEHTTVMDGH VDCGVGLSRE QMKALDRQAQ RPLNFSPLLR CKSKESLASE
1310 1320 1330 1340 1350
SSNQTSGYQS GYHSDDAEAP IYANEEMILK RDIRKKPPLP KRNDKFSAEV

RYSAPPV
Length:1,357
Mass (Da):153,042
Last modified:October 14, 2008 - v2
Checksum:i43B97B484DBEA38F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17F → V in AAI63563 (PubMed:23594743).Curated1
Sequence conflicti72T → S in AAI63563 (PubMed:23594743).Curated1
Sequence conflicti109L → P in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti254L → R in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti262W → C in AAI63563 (PubMed:23594743).Curated1
Sequence conflicti287K → R in AAS92270 (Ref. 1) Curated1
Sequence conflicti384E → G in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti459A → G in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti488 – 489TR → PS in AAY89336 (PubMed:17698971).Curated2
Sequence conflicti488 – 489TR → PS in AAI63563 (PubMed:23594743).Curated2
Sequence conflicti553F → S in AAS92270 (Ref. 1) Curated1
Sequence conflicti958R → K in AAS92270 (Ref. 1) Curated1
Sequence conflicti996Y → S in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti996Y → S in AAI63563 (PubMed:23594743).Curated1
Sequence conflicti996Y → S in AAV93319 (PubMed:16617120).Curated1
Sequence conflicti997K → T in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti997K → T in AAI63563 (PubMed:23594743).Curated1
Sequence conflicti1100W → R in AAS92270 (Ref. 1) Curated1
Sequence conflicti1223D → G in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti1234M → I in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti1234M → I in AAI63563 (PubMed:23594743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY523999 mRNA Translation: AAS92270.1
DQ026829 mRNA Translation: AAY89336.1
BX088688, BX511058 Genomic DNA Translation: CAM14201.1
BX248242 Genomic DNA Translation: CAI11526.1
BX511058, BX088688 Genomic DNA Translation: CAH68950.2
BC163563 mRNA Translation: AAI63563.1
AY833405 mRNA Translation: AAV93319.1
RefSeqiNP_001019824.2, NM_001024653.2
UniGeneiDr.91385

Genome annotation databases

EnsembliENSDART00000049204; ENSDARP00000049203; ENSDARG00000017321
GeneIDi554230
KEGGidre:554230

Similar proteinsi

Entry informationi

Entry nameiVGFR2_DANRE
AccessioniPrimary (citable) accession number: Q5GIT4
Secondary accession number(s): B3DJQ0
, Q1ANK7, Q5MD88, Q5RIP2, Q5TZ34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 14, 2008
Last modified: May 23, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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