Q5GH77 (XKR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
XK-related protein 3

Alternative name(s):
X Kell blood group-related 3
XTES

Gene names

Name:	XKR3
Synonyms:	XRG3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Ref.2.
Tissue specificity	Expressed predominantly, if not exclusively, in testis. Ref.2
Sequence similarities	Belongs to the XK family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 459	459	XK-related protein 3		PRO_0000190776
Regions
	Transmembrane	35 – 55	21	Helical; Potential
	Transmembrane	68 – 88	21	Helical; Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Transmembrane	169 – 189	21	Helical; Potential
	Transmembrane	199 – 219	21	Helical; Potential
	Transmembrane	238 – 258	21	Helical; Potential
	Transmembrane	264 – 284	21	Helical; Potential
	Transmembrane	300 – 320	21	Helical; Potential
	Transmembrane	345 – 365	21	Helical; Potential
	Transmembrane	377 – 397	21	Helical; Potential
Natural variations
	Natural variant	143	1	T → M. Corresponds to variant rs5748648 [ dbSNP | Ensembl ].		VAR_053740
	Natural variant	232	1	P → L. Ref.3 Corresponds to variant rs9605146 [ dbSNP | Ensembl ].		VAR_053741
	Natural variant	255	1	F → L. Ref.2 Ref.3 Corresponds to variant rs5748623 [ dbSNP | Ensembl ].		VAR_053742
	Natural variant	442	1	H → N. Ref.2 Ref.3 Corresponds to variant rs5748622 [ dbSNP | Ensembl ].		VAR_053743

Sequences

	Sequence		Length	Mass (Da)
	Q5GH77 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 291FDD2A952F6BD8	FASTA	459	53,448
	10 20 30 40 50 60 METVFEEMDE ESTGGVSSSK EEIVLGQRLH LSFPFSIIFS TVLYCGEVAF GLYMFEIYRK 70 80 90 100 110 120 ANDTFWMSFT ISFIIVGAIL DQIILMFFNK DLRRNKAALL FWHILLLGPI VRCLHTIRNY 130 140 150 160 170 180 HKWLKNLKQE KEETQVSITK RNTMLEREIA FSIRDNFMQQ KAFKYMSVIQ AFLGSVPQLI 190 200 210 220 230 240 LQMYISLTIR EWPLNRALLM TFSLLSVTYG AIRCNILAIQ ISNDDTTIKL PPIEFFCVVM 250 260 270 280 290 300 WRFLEVISRV VTLAFFIASL KLKSLPVLLI IYFVSLLAPW LEFWKSGAHL PGNKENNSNM 310 320 330 340 350 360 VGTVLMLFLI TLLYAAINFS CWSAVKLQLS DDKIIDGRQR WGHRILHYSF QFLENVIMIL 370 380 390 400 410 420 VFRFFGGKTL LNCCDSLIAV QLIISYLLAT GFMLLFYQYL YPWQSGKVLP GRTENQPEAP 430 440 450 YYYVNIEKTE KNKNKQLRNY CHSCNRVGYF SIRKSMTCS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates." Huang C.-H., Chen Y. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of two new members, XPLAC and XTES, of the XK family." Calenda G., Peng J., Redman C.M., Sha Q., Wu X., Lee S. Gene 370:6-16(2006) [PubMed: 16431037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS LEU-255 AND ASN-442. Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-232; LEU-255 AND ASN-442. Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY534240 mRNA. Translation: AAT07089.1. AY989815 mRNA. Translation: AAX86010.1. AK098608 mRNA. Translation: BAC05352.1. BC137521 mRNA. Translation: AAI37522.1. BC137522 mRNA. Translation: AAI37523.1.
IPI	IPI00395979.
RefSeq	NP_787074.2. NM_175878.3.
UniGene	Hs.356069.
3D structure databases
ProteinModelPortal	Q5GH77.
ModBase	Search...
Polymorphism databases
DMDM	74707819.
Proteomic databases
PRIDE	Q5GH77.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331428; ENSP00000331704; ENSG00000172967.
GeneID	150165.
KEGG	hsa:150165.
UCSC	uc002zlv.1. human.
Organism-specific databases
CTD	150165.
GeneCards	GC22M017264.
H-InvDB	HIX0016204.
HGNC	HGNC:28778. XKR3.
HPA	HPA003379.
MIM	611674. gene.
neXtProt	NX_Q5GH77.
PharmGKB	PA142670562.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG22451.
GeneTree	ENSGT00390000003231.
HOGENOM	HBG283821.
HOVERGEN	HBG055838.
InParanoid	Q5GH77.
OMA	LAPWLEF.
OrthoDB	EOG4RBQJJ.
PhylomeDB	Q5GH77.
Gene expression databases
ArrayExpress	Q5GH77.
Bgee	Q5GH77.
CleanEx	HS_XKR3.
Genevestigator	Q5GH77.
Family and domain databases
InterPro	IPR018629. Transport_prot_XK. [Graphical view]
Pfam	PF09815. XK-related. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	86354.
SOURCE	Search...

Entry information

Entry name

XKR3_HUMAN

Accession

Primary (citable) accession number: Q5GH77
Secondary accession number(s): B2RPN1, Q52PG8, Q8N7E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.