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Protein

XK-related protein 3

Gene

XKR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi2.A.112.1.7. 2.a.112. the kx blood-group antigen (kxa) family.

Names & Taxonomyi

Protein namesi
Recommended name:
XK-related protein 3
Alternative name(s):
X Kell blood group-related 3
XTES
Gene namesi
Name:XKR3
Synonyms:XRG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:28778. XKR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence analysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence analysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence analysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence analysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670562.

Polymorphism and mutation databases

BioMutaiXKR3.
DMDMi74707819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459XK-related protein 3PRO_0000190776Add
BLAST

Proteomic databases

PaxDbiQ5GH77.
PRIDEiQ5GH77.

PTM databases

PhosphoSiteiQ5GH77.

Expressioni

Tissue specificityi

Expressed predominantly, if not exclusively, in testis.1 Publication

Gene expression databases

BgeeiQ5GH77.
CleanExiHS_XKR3.

Organism-specific databases

HPAiHPA003379.
HPA035081.

Interactioni

Protein-protein interaction databases

BioGridi127266. 1 interaction.
STRINGi9606.ENSP00000331704.

Structurei

3D structure databases

ProteinModelPortaliQ5GH77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCAN. Eukaryota.
ENOG4110P5T. LUCA.
GeneTreeiENSGT00390000003231.
HOGENOMiHOG000118070.
HOVERGENiHBG055838.
InParanoidiQ5GH77.
OMAiWMSFTIS.
OrthoDBiEOG7034H1.
PhylomeDBiQ5GH77.
TreeFamiTF331465.

Family and domain databases

InterProiIPR018629. XK_fam.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5GH77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVFEEMDE ESTGGVSSSK EEIVLGQRLH LSFPFSIIFS TVLYCGEVAF
60 70 80 90 100
GLYMFEIYRK ANDTFWMSFT ISFIIVGAIL DQIILMFFNK DLRRNKAALL
110 120 130 140 150
FWHILLLGPI VRCLHTIRNY HKWLKNLKQE KEETQVSITK RNTMLEREIA
160 170 180 190 200
FSIRDNFMQQ KAFKYMSVIQ AFLGSVPQLI LQMYISLTIR EWPLNRALLM
210 220 230 240 250
TFSLLSVTYG AIRCNILAIQ ISNDDTTIKL PPIEFFCVVM WRFLEVISRV
260 270 280 290 300
VTLAFFIASL KLKSLPVLLI IYFVSLLAPW LEFWKSGAHL PGNKENNSNM
310 320 330 340 350
VGTVLMLFLI TLLYAAINFS CWSAVKLQLS DDKIIDGRQR WGHRILHYSF
360 370 380 390 400
QFLENVIMIL VFRFFGGKTL LNCCDSLIAV QLIISYLLAT GFMLLFYQYL
410 420 430 440 450
YPWQSGKVLP GRTENQPEAP YYYVNIEKTE KNKNKQLRNY CHSCNRVGYF

SIRKSMTCS
Length:459
Mass (Da):53,448
Last modified:March 1, 2005 - v1
Checksum:i291FDD2A952F6BD8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti143 – 1431T → M.
Corresponds to variant rs5748648 [ dbSNP | Ensembl ].
VAR_053740
Natural varianti232 – 2321P → L.1 Publication
Corresponds to variant rs9605146 [ dbSNP | Ensembl ].
VAR_053741
Natural varianti255 – 2551F → L.2 Publications
Corresponds to variant rs5748623 [ dbSNP | Ensembl ].
VAR_053742
Natural varianti442 – 4421H → N.2 Publications
Corresponds to variant rs5748622 [ dbSNP | Ensembl ].
VAR_053743

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534240 mRNA. Translation: AAT07089.1.
AY989815 mRNA. Translation: AAX86010.1.
AK098608 mRNA. Translation: BAC05352.1.
BC137521 mRNA. Translation: AAI37522.1.
BC137522 mRNA. Translation: AAI37523.1.
CCDSiCCDS42975.1.
RefSeqiNP_001305180.1. NM_001318251.1.
NP_787074.2. NM_175878.4.
UniGeneiHs.356069.

Genome annotation databases

EnsembliENST00000331428; ENSP00000331704; ENSG00000172967.
GeneIDi150165.
KEGGihsa:150165.
UCSCiuc002zlv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534240 mRNA. Translation: AAT07089.1.
AY989815 mRNA. Translation: AAX86010.1.
AK098608 mRNA. Translation: BAC05352.1.
BC137521 mRNA. Translation: AAI37522.1.
BC137522 mRNA. Translation: AAI37523.1.
CCDSiCCDS42975.1.
RefSeqiNP_001305180.1. NM_001318251.1.
NP_787074.2. NM_175878.4.
UniGeneiHs.356069.

3D structure databases

ProteinModelPortaliQ5GH77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127266. 1 interaction.
STRINGi9606.ENSP00000331704.

Protein family/group databases

TCDBi2.A.112.1.7. 2.a.112. the kx blood-group antigen (kxa) family.

PTM databases

PhosphoSiteiQ5GH77.

Polymorphism and mutation databases

BioMutaiXKR3.
DMDMi74707819.

Proteomic databases

PaxDbiQ5GH77.
PRIDEiQ5GH77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331428; ENSP00000331704; ENSG00000172967.
GeneIDi150165.
KEGGihsa:150165.
UCSCiuc002zlv.4. human.

Organism-specific databases

CTDi150165.
GeneCardsiXKR3.
HGNCiHGNC:28778. XKR3.
HPAiHPA003379.
HPA035081.
MIMi611674. gene.
neXtProtiNX_Q5GH77.
PharmGKBiPA142670562.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCAN. Eukaryota.
ENOG4110P5T. LUCA.
GeneTreeiENSGT00390000003231.
HOGENOMiHOG000118070.
HOVERGENiHBG055838.
InParanoidiQ5GH77.
OMAiWMSFTIS.
OrthoDBiEOG7034H1.
PhylomeDBiQ5GH77.
TreeFamiTF331465.

Miscellaneous databases

ChiTaRSiXKR3. human.
GenomeRNAii150165.
NextBioi86354.
PROiQ5GH77.
SOURCEiSearch...

Gene expression databases

BgeeiQ5GH77.
CleanExiHS_XKR3.

Family and domain databases

InterProiIPR018629. XK_fam.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates."
    Huang C.-H., Chen Y.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of two new members, XPLAC and XTES, of the XK family."
    Calenda G., Peng J., Redman C.M., Sha Q., Wu X., Lee S.
    Gene 370:6-16(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS LEU-255 AND ASN-442.
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-232; LEU-255 AND ASN-442.
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiXKR3_HUMAN
AccessioniPrimary (citable) accession number: Q5GH77
Secondary accession number(s): B2RPN1, Q52PG8, Q8N7E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2005
Last modified: March 16, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.