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Protein

XK-related protein 3

Gene

XKR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi2.A.112.1.7. 2.a.112. the kx blood-group antigen (kxa) family.

Names & Taxonomyi

Protein namesi
Recommended name:
XK-related protein 3
Alternative name(s):
X Kell blood group-related 3
XTES
Gene namesi
Name:XKR3
Synonyms:XRG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:28778. XKR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi150165.
OpenTargetsiENSG00000172967.
PharmGKBiPA142670562.

Polymorphism and mutation databases

BioMutaiXKR3.
DMDMi74707819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001907761 – 459XK-related protein 3Add BLAST459

Proteomic databases

PaxDbiQ5GH77.
PRIDEiQ5GH77.

PTM databases

iPTMnetiQ5GH77.
PhosphoSitePlusiQ5GH77.

Expressioni

Tissue specificityi

Expressed predominantly, if not exclusively, in testis.1 Publication

Gene expression databases

BgeeiENSG00000172967.
CleanExiHS_XKR3.

Organism-specific databases

HPAiHPA003379.
HPA035081.

Interactioni

Protein-protein interaction databases

BioGridi127266. 1 interactor.
STRINGi9606.ENSP00000331704.

Structurei

3D structure databases

ProteinModelPortaliQ5GH77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCAN. Eukaryota.
ENOG4110P5T. LUCA.
GeneTreeiENSGT00390000003231.
HOGENOMiHOG000118070.
HOVERGENiHBG055838.
InParanoidiQ5GH77.
OMAiWMSFTIS.
OrthoDBiEOG091G07Y7.
PhylomeDBiQ5GH77.
TreeFamiTF331465.

Family and domain databases

InterProiIPR018629. XK_rel.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5GH77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVFEEMDE ESTGGVSSSK EEIVLGQRLH LSFPFSIIFS TVLYCGEVAF
60 70 80 90 100
GLYMFEIYRK ANDTFWMSFT ISFIIVGAIL DQIILMFFNK DLRRNKAALL
110 120 130 140 150
FWHILLLGPI VRCLHTIRNY HKWLKNLKQE KEETQVSITK RNTMLEREIA
160 170 180 190 200
FSIRDNFMQQ KAFKYMSVIQ AFLGSVPQLI LQMYISLTIR EWPLNRALLM
210 220 230 240 250
TFSLLSVTYG AIRCNILAIQ ISNDDTTIKL PPIEFFCVVM WRFLEVISRV
260 270 280 290 300
VTLAFFIASL KLKSLPVLLI IYFVSLLAPW LEFWKSGAHL PGNKENNSNM
310 320 330 340 350
VGTVLMLFLI TLLYAAINFS CWSAVKLQLS DDKIIDGRQR WGHRILHYSF
360 370 380 390 400
QFLENVIMIL VFRFFGGKTL LNCCDSLIAV QLIISYLLAT GFMLLFYQYL
410 420 430 440 450
YPWQSGKVLP GRTENQPEAP YYYVNIEKTE KNKNKQLRNY CHSCNRVGYF

SIRKSMTCS
Length:459
Mass (Da):53,448
Last modified:March 1, 2005 - v1
Checksum:i291FDD2A952F6BD8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053740143T → M.Corresponds to variant rs5748648dbSNPEnsembl.1
Natural variantiVAR_053741232P → L.1 PublicationCorresponds to variant rs9605146dbSNPEnsembl.1
Natural variantiVAR_053742255F → L.2 PublicationsCorresponds to variant rs5748623dbSNPEnsembl.1
Natural variantiVAR_053743442H → N.2 PublicationsCorresponds to variant rs5748622dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534240 mRNA. Translation: AAT07089.1.
AY989815 mRNA. Translation: AAX86010.1.
AK098608 mRNA. Translation: BAC05352.1.
BC137521 mRNA. Translation: AAI37522.1.
BC137522 mRNA. Translation: AAI37523.1.
CCDSiCCDS42975.1.
RefSeqiNP_001305180.1. NM_001318251.1.
NP_787074.2. NM_175878.4.
XP_016884089.1. XM_017028600.1.
UniGeneiHs.356069.

Genome annotation databases

EnsembliENST00000331428; ENSP00000331704; ENSG00000172967.
GeneIDi150165.
KEGGihsa:150165.
UCSCiuc002zlv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534240 mRNA. Translation: AAT07089.1.
AY989815 mRNA. Translation: AAX86010.1.
AK098608 mRNA. Translation: BAC05352.1.
BC137521 mRNA. Translation: AAI37522.1.
BC137522 mRNA. Translation: AAI37523.1.
CCDSiCCDS42975.1.
RefSeqiNP_001305180.1. NM_001318251.1.
NP_787074.2. NM_175878.4.
XP_016884089.1. XM_017028600.1.
UniGeneiHs.356069.

3D structure databases

ProteinModelPortaliQ5GH77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127266. 1 interactor.
STRINGi9606.ENSP00000331704.

Protein family/group databases

TCDBi2.A.112.1.7. 2.a.112. the kx blood-group antigen (kxa) family.

PTM databases

iPTMnetiQ5GH77.
PhosphoSitePlusiQ5GH77.

Polymorphism and mutation databases

BioMutaiXKR3.
DMDMi74707819.

Proteomic databases

PaxDbiQ5GH77.
PRIDEiQ5GH77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331428; ENSP00000331704; ENSG00000172967.
GeneIDi150165.
KEGGihsa:150165.
UCSCiuc002zlv.4. human.

Organism-specific databases

CTDi150165.
DisGeNETi150165.
GeneCardsiXKR3.
HGNCiHGNC:28778. XKR3.
HPAiHPA003379.
HPA035081.
MIMi611674. gene.
neXtProtiNX_Q5GH77.
OpenTargetsiENSG00000172967.
PharmGKBiPA142670562.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCAN. Eukaryota.
ENOG4110P5T. LUCA.
GeneTreeiENSGT00390000003231.
HOGENOMiHOG000118070.
HOVERGENiHBG055838.
InParanoidiQ5GH77.
OMAiWMSFTIS.
OrthoDBiEOG091G07Y7.
PhylomeDBiQ5GH77.
TreeFamiTF331465.

Miscellaneous databases

ChiTaRSiXKR3. human.
GenomeRNAii150165.
PROiQ5GH77.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172967.
CleanExiHS_XKR3.

Family and domain databases

InterProiIPR018629. XK_rel.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXKR3_HUMAN
AccessioniPrimary (citable) accession number: Q5GH77
Secondary accession number(s): B2RPN1, Q52PG8, Q8N7E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.