Q5GH76 (XKR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
XK-related protein 4

Gene names

Name:	XKR4
Synonyms:	KIAA1889, XRG4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	650 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the XK family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 650	650	XK-related protein 4		PRO_0000190777
Regions
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	144 – 164	21	Helical; Potential
	Transmembrane	248 – 268	21	Helical; Potential
	Transmembrane	306 – 326	21	Helical; Potential
	Transmembrane	331 – 351	21	Helical; Potential
	Transmembrane	365 – 385	21	Helical; Potential
	Transmembrane	396 – 418	23	Helical; Potential
	Transmembrane	428 – 448	21	Helical; Potential
	Transmembrane	457 – 477	21	Helical; Potential
	Transmembrane	487 – 507	21	Helical; Potential
Amino acid modifications
	Modified residue	648	1	Phosphothreonine Ref.3
	Modified residue	649	1	Phosphothreonine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q5GH76 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 12FD197BD5F54C19	FASTA	650	71,501
	10 20 30 40 50 60 MAAKSDGRLK MKKSSDVAFT PLQNSDHSGS VQGLAPGLPS GSGAEDEEAA GGGCCPDGGG 70 80 90 100 110 120 CSRCCCCCAG SGGSAGSGGS GGVAGPGGGG AGSAALCLRL GREQRRYSLW DCLWILAAVA 130 140 150 160 170 180 VYFADVGTDV WLAVDYYLRG QRWWFGLTLF FVVLGSLSVQ VFSFRWFVHD FSTEDSATAA 190 200 210 220 230 240 AASSCPQPGA DCKTVVGGGS AAGEGEARPS TPQRQASNAS KSNIAAANSG SNSSGATRAS 250 260 270 280 290 300 GKHRSASCSF CIWLLQSLIH ILQLGQIWRY FHTIYLGIRS RQSGENDRWR FYWKMVYEYA 310 320 330 340 350 360 DVSMLHLLAT FLESAPQLVL QLCIIVQTHS LQALQGFTAA ASLVSLAWAL ASYQKALRDS 370 380 390 400 410 420 RDDKKPISYM AVIIQFCWHF FTIAARVITF ALFASVFQLY FGIFIVLHWC IMTFWIVHCE 430 440 450 460 470 480 TEFCITKWEE IVFDMVVGII YIFSWFNVKE GRTRCRLFIY YFVILLENTA LSALWYLYKA 490 500 510 520 530 540 PQIADAFAIP ALCVVFSSFL TGVVFMLMYY AFFHPNGPRF GQSPSCACED PAAAFTLPPD 550 560 570 580 590 600 VATSTLRSIS NNRSVVSDRD QKFAERDGCV PVFQVRPTAP STPSSRPPRI EESVIKIDLF 610 620 630 640 650 RNRYPAWERH VLDRSLRKAI LAFECSPSPP RLQYKDDALI QERLEYETTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates." Huang C.-H., Chen Y. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:179-187(2001) [PubMed: 11572484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 146-650. Tissue: Brain.
[3]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-648 AND THR-649, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY534241 mRNA. Translation: AAT07090.1. AB067476 mRNA. Translation: BAB67782.1.
IPI	IPI00174859.
RefSeq	NP_443130.1. NM_052898.1.
UniGene	Hs.130197.
3D structure databases
ProteinModelPortal	Q5GH76.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5GH76.
PTM databases
PhosphoSite	Q5GH76.
Polymorphism databases
DMDM	74707818.
Proteomic databases
PRIDE	Q5GH76.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327381; ENSP00000328326; ENSG00000206579.
GeneID	114786.
KEGG	hsa:114786.
UCSC	uc003xsf.1. human.
Organism-specific databases
CTD	114786.
GeneCards	GC08P056015.
H-InvDB	HIX0007512.
HGNC	HGNC:29394. XKR4.
HPA	HPA025072. HPA028083.
neXtProt	NX_Q5GH76.
PharmGKB	PA142670563.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08570.
GeneTree	ENSGT00530000062854.
HOGENOM	HBG713827.
HOVERGEN	HBG055841.
InParanoid	Q5GH76.
OMA	VGTDVWL.
OrthoDB	EOG4XPQFM.
PhylomeDB	Q5GH76.
Gene expression databases
Bgee	Q5GH76.
CleanEx	HS_XKR4.
Genevestigator	Q5GH76.
GermOnline	ENSG00000206579. Homo sapiens.
Family and domain databases
InterPro	IPR018629. Transport_prot_XK. [Graphical view]
Pfam	PF09815. XK-related. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	79179.

Entry information

Entry name

XKR4_HUMAN

Accession

Primary (citable) accession number: Q5GH76
Secondary accession number(s): Q96PZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.