Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

XK-related protein 4

Gene

XKR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32159-MONOMER.

Protein family/group databases

TCDBi2.A.112.1.11. 2.a.112. the kx blood-group antigen (kxa) family.

Names & Taxonomyi

Protein namesi
Recommended name:
XK-related protein 4
Gene namesi
Name:XKR4
Synonyms:KIAA1889, XRG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:29394. XKR4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei396 – 418HelicalSequence analysisAdd BLAST23
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114786.
OpenTargetsiENSG00000206579.
PharmGKBiPA142670563.

Polymorphism and mutation databases

BioMutaiXKR4.
DMDMi74707818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001907771 – 650XK-related protein 4Add BLAST650

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei200PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5GH76.
PeptideAtlasiQ5GH76.
PRIDEiQ5GH76.

PTM databases

iPTMnetiQ5GH76.
PhosphoSitePlusiQ5GH76.

Expressioni

Gene expression databases

BgeeiENSG00000206579.
CleanExiHS_XKR4.
GenevisibleiQ5GH76. HS.

Organism-specific databases

HPAiHPA025072.
HPA028083.

Interactioni

Protein-protein interaction databases

BioGridi125348. 1 interactor.
IntActiQ5GH76. 1 interactor.
STRINGi9606.ENSP00000328326.

Structurei

3D structure databases

ProteinModelPortaliQ5GH76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4790. Eukaryota.
ENOG410YRUD. LUCA.
GeneTreeiENSGT00530000062854.
HOGENOMiHOG000231915.
HOVERGENiHBG055841.
InParanoidiQ5GH76.
OMAiTDVWLSV.
OrthoDBiEOG091G048S.
PhylomeDBiQ5GH76.
TreeFamiTF316454.

Family and domain databases

InterProiIPR018629. XK_rel.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5GH76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKSDGRLK MKKSSDVAFT PLQNSDHSGS VQGLAPGLPS GSGAEDEEAA
60 70 80 90 100
GGGCCPDGGG CSRCCCCCAG SGGSAGSGGS GGVAGPGGGG AGSAALCLRL
110 120 130 140 150
GREQRRYSLW DCLWILAAVA VYFADVGTDV WLAVDYYLRG QRWWFGLTLF
160 170 180 190 200
FVVLGSLSVQ VFSFRWFVHD FSTEDSATAA AASSCPQPGA DCKTVVGGGS
210 220 230 240 250
AAGEGEARPS TPQRQASNAS KSNIAAANSG SNSSGATRAS GKHRSASCSF
260 270 280 290 300
CIWLLQSLIH ILQLGQIWRY FHTIYLGIRS RQSGENDRWR FYWKMVYEYA
310 320 330 340 350
DVSMLHLLAT FLESAPQLVL QLCIIVQTHS LQALQGFTAA ASLVSLAWAL
360 370 380 390 400
ASYQKALRDS RDDKKPISYM AVIIQFCWHF FTIAARVITF ALFASVFQLY
410 420 430 440 450
FGIFIVLHWC IMTFWIVHCE TEFCITKWEE IVFDMVVGII YIFSWFNVKE
460 470 480 490 500
GRTRCRLFIY YFVILLENTA LSALWYLYKA PQIADAFAIP ALCVVFSSFL
510 520 530 540 550
TGVVFMLMYY AFFHPNGPRF GQSPSCACED PAAAFTLPPD VATSTLRSIS
560 570 580 590 600
NNRSVVSDRD QKFAERDGCV PVFQVRPTAP STPSSRPPRI EESVIKIDLF
610 620 630 640 650
RNRYPAWERH VLDRSLRKAI LAFECSPSPP RLQYKDDALI QERLEYETTL
Length:650
Mass (Da):71,501
Last modified:March 1, 2005 - v1
Checksum:i12FD197BD5F54C19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534241 mRNA. Translation: AAT07090.1.
AB067476 mRNA. Translation: BAB67782.1.
CCDSiCCDS34893.1.
RefSeqiNP_443130.1. NM_052898.1.
UniGeneiHs.130197.

Genome annotation databases

EnsembliENST00000327381; ENSP00000328326; ENSG00000206579.
ENST00000622811; ENSP00000480076; ENSG00000206579.
GeneIDi114786.
KEGGihsa:114786.
UCSCiuc003xsf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534241 mRNA. Translation: AAT07090.1.
AB067476 mRNA. Translation: BAB67782.1.
CCDSiCCDS34893.1.
RefSeqiNP_443130.1. NM_052898.1.
UniGeneiHs.130197.

3D structure databases

ProteinModelPortaliQ5GH76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125348. 1 interactor.
IntActiQ5GH76. 1 interactor.
STRINGi9606.ENSP00000328326.

Protein family/group databases

TCDBi2.A.112.1.11. 2.a.112. the kx blood-group antigen (kxa) family.

PTM databases

iPTMnetiQ5GH76.
PhosphoSitePlusiQ5GH76.

Polymorphism and mutation databases

BioMutaiXKR4.
DMDMi74707818.

Proteomic databases

PaxDbiQ5GH76.
PeptideAtlasiQ5GH76.
PRIDEiQ5GH76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327381; ENSP00000328326; ENSG00000206579.
ENST00000622811; ENSP00000480076; ENSG00000206579.
GeneIDi114786.
KEGGihsa:114786.
UCSCiuc003xsf.4. human.

Organism-specific databases

CTDi114786.
DisGeNETi114786.
GeneCardsiXKR4.
HGNCiHGNC:29394. XKR4.
HPAiHPA025072.
HPA028083.
neXtProtiNX_Q5GH76.
OpenTargetsiENSG00000206579.
PharmGKBiPA142670563.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4790. Eukaryota.
ENOG410YRUD. LUCA.
GeneTreeiENSGT00530000062854.
HOGENOMiHOG000231915.
HOVERGENiHBG055841.
InParanoidiQ5GH76.
OMAiTDVWLSV.
OrthoDBiEOG091G048S.
PhylomeDBiQ5GH76.
TreeFamiTF316454.

Enzyme and pathway databases

BioCyciZFISH:G66-32159-MONOMER.

Miscellaneous databases

ChiTaRSiXKR4. human.
GenomeRNAii114786.
PROiQ5GH76.

Gene expression databases

BgeeiENSG00000206579.
CleanExiHS_XKR4.
GenevisibleiQ5GH76. HS.

Family and domain databases

InterProiIPR018629. XK_rel.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXKR4_HUMAN
AccessioniPrimary (citable) accession number: Q5GH76
Secondary accession number(s): Q96PZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.