Q5GH73 (XKR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
XK-related protein 6

Gene names

Name:	XKR6
Synonyms:	C8orf21, C8orf5, C8orf7, XRG6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	641 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the XK family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5GH73-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q5GH73-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 641	641	XK-related protein 6		PRO_0000190785
Regions
	Transmembrane	130 – 150	21	Helical; Potential
	Transmembrane	159 – 179	21	Helical; Potential
	Transmembrane	318 – 338	21	Helical; Potential
	Transmembrane	372 – 392	21	Helical; Potential
	Transmembrane	413 – 433	21	Helical; Potential
	Transmembrane	442 – 462	21	Helical; Potential
	Transmembrane	473 – 493	21	Helical; Potential
	Compositional bias	7 – 49	43	Gly-rich
	Compositional bias	94 – 125	32	Pro-rich
Natural variations
	Alternative sequence	1 – 279	279	Missing in isoform 2.		VSP_014663

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: DEFFE0EE7CB43C79	FASTA	641	71,638
	10 20 30 40 50 60 MAAKSDGGGV GVGFAQLHNL DEAVGSGGEE DGEPGGGGCG GGGDGSEPGE SSSMHICHCC 70 80 90 100 110 120 NTSSCYWGCR SACLRSLLGR KPRRSAAADG GDQPLQPPAA PGAGRQPPTP SAARPEPPPP 130 140 150 160 170 180 QVERPWLDCL WIVLALLVFF GDVGTDLWLA LDYYRKGDYV YFGLTLFFVL VPSLLVQSLS 190 200 210 220 230 240 FRWFVQDYTG GGLGAVEGLT SRGPPMMGAG YVHGAARGGP GVRVSPTPGA QRLCRLSVWI 250 260 270 280 290 300 WQSVIHLLQM GQVWRYIRTM YLGIQSQRRK EHQRRFYWAM MYEYADVNML RLLETFLESA 310 320 330 340 350 360 PQLVLQLYIM LQKNSAETLP CVSSVTSLMS LAWVLASYHK LLRDSRDDKK SMSYRGAIIQ 370 380 390 400 410 420 VFWRLFTISS RVISFALFAS IFQLYFGIFV VVHWCAMAFW IIHGGTDFCM SKWEEILFNM 430 440 450 460 470 480 VVGIVYIFCW FNVKEGRTRY RMFAYYTIVL TENAALTFLW YFYRDPETTD SYAVPALCCV 490 500 510 520 530 540 FISFVAGIAM MLLYYGVLHP TGPRAKILAS SCCAELLWGI PLPPDVEPMA PEIPGYRGTQ 550 560 570 580 590 600 VTPTRAVTEQ QEDLTADTCL PVFQVRPMGP PTPLGRPYLP EGPLIKIDMP RKRYPAWDAH 610 620 630 640 FVDRRLRRTI NILQYVTPTA VGIRYRDGPL LYELLQYESS L
	Isoform 2 [UniParc]. Checksum: C19D2D71A2377610	FASTA	362	41,673
	10 20 30 40 50 60 MMYEYADVNM LRLLETFLES APQLVLQLYI MLQKNSAETL PCVSSVTSLM SLAWVLASYH 70 80 90 100 110 120 KLLRDSRDDK KSMSYRGAII QVFWRLFTIS SRVISFALFA SIFQLYFGIF VVVHWCAMAF 130 140 150 160 170 180 WIIHGGTDFC MSKWEEILFN MVVGIVYIFC WFNVKEGRTR YRMFAYYTIV LTENAALTFL 190 200 210 220 230 240 WYFYRDPETT DSYAVPALCC VFISFVAGIA MMLLYYGVLH PTGPRAKILA SSCCAELLWG 250 260 270 280 290 300 IPLPPDVEPM APEIPGYRGT QVTPTRAVTE QQEDLTADTC LPVFQVRPMG PPTPLGRPYL 310 320 330 340 350 360 PEGPLIKIDM PRKRYPAWDA HFVDRRLRRT INILQYVTPT AVGIRYRDGP LLYELLQYES SL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates." Huang C.-H., Chen Y. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lymph.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY534244 mRNA. Translation: AAT07093.1. BC024146 mRNA. Translation: AAH24146.1.
IPI	IPI00552082. IPI00797673.
RefSeq	NP_775954.2. NM_173683.3.
UniGene	Hs.657083. Hs.665456. Hs.666146.
3D structure databases
ProteinModelPortal	Q5GH73.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5GH73.
PTM databases
PhosphoSite	Q5GH73.
Polymorphism databases
DMDM	71153416.
Proteomic databases
PRIDE	Q5GH73.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000416569; ENSP00000416707; ENSG00000171044.
GeneID	286046.
KEGG	hsa:286046.
UCSC	uc003wtk.1. human.
Organism-specific databases
CTD	286046.
GeneCards	GC08M010794.
HGNC	HGNC:27806. XKR6.
HPA	HPA024828.
neXtProt	NX_Q5GH73.
PharmGKB	PA134922549.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15328.
GeneTree	ENSGT00530000062854.
HOGENOM	HBG713827.
HOVERGEN	HBG055841.
InParanoid	Q5GH73.
OMA	PNAVGIR.
OrthoDB	EOG4QC151.
PhylomeDB	Q5GH73.
Gene expression databases
ArrayExpress	Q5GH73.
Bgee	Q5GH73.
CleanEx	HS_XKR6.
Genevestigator	Q5GH73.
GermOnline	ENSG00000171044. Homo sapiens.
Family and domain databases
InterPro	IPR018629. Transport_prot_XK. [Graphical view]
Pfam	PF09815. XK-related. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	95939.

Entry information

Entry name

XKR6_HUMAN

Accession

Primary (citable) accession number: Q5GH73
Secondary accession number(s): Q8TBA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.