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Protein

XK-related protein 6

Gene

XKR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
XK-related protein 6
Gene namesi
Name:XKR6
Synonyms:C8orf21, C8orf5, C8orf7, XRG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:27806. XKR6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence analysisAdd
BLAST
Transmembranei442 – 46221HelicalSequence analysisAdd
BLAST
Transmembranei473 – 49321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922549.

Polymorphism and mutation databases

BioMutaiXKR6.
DMDMi71153416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 641641XK-related protein 6PRO_0000190785Add
BLAST

Proteomic databases

PaxDbiQ5GH73.
PeptideAtlasiQ5GH73.
PRIDEiQ5GH73.

PTM databases

iPTMnetiQ5GH73.
PhosphoSiteiQ5GH73.

Expressioni

Gene expression databases

BgeeiENSG00000171044.
CleanExiHS_XKR6.
ExpressionAtlasiQ5GH73. baseline and differential.
GenevisibleiQ5GH73. HS.

Organism-specific databases

HPAiHPA024828.

Interactioni

Protein-protein interaction databases

BioGridi130280. 1 interaction.
STRINGi9606.ENSP00000416707.

Structurei

3D structure databases

ProteinModelPortaliQ5GH73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 4943Gly-richAdd
BLAST
Compositional biasi94 – 12532Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4790. Eukaryota.
ENOG410YRUD. LUCA.
GeneTreeiENSGT00530000062854.
HOGENOMiHOG000231915.
HOVERGENiHBG055841.
InParanoidiQ5GH73.
OMAiLSVWVWQ.
OrthoDBiEOG091G048S.
PhylomeDBiQ5GH73.
TreeFamiTF316454.

Family and domain databases

InterProiIPR018629. XK_fam.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5GH73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAKSDGGGV GVGFAQLHNL DEAVGSGGEE DGEPGGGGCG GGGDGSEPGE
60 70 80 90 100
SSSMHICHCC NTSSCYWGCR SACLRSLLGR KPRRSAAADG GDQPLQPPAA
110 120 130 140 150
PGAGRQPPTP SAARPEPPPP QVERPWLDCL WIVLALLVFF GDVGTDLWLA
160 170 180 190 200
LDYYRKGDYV YFGLTLFFVL VPSLLVQSLS FRWFVQDYTG GGLGAVEGLT
210 220 230 240 250
SRGPPMMGAG YVHGAARGGP GVRVSPTPGA QRLCRLSVWI WQSVIHLLQM
260 270 280 290 300
GQVWRYIRTM YLGIQSQRRK EHQRRFYWAM MYEYADVNML RLLETFLESA
310 320 330 340 350
PQLVLQLYIM LQKNSAETLP CVSSVTSLMS LAWVLASYHK LLRDSRDDKK
360 370 380 390 400
SMSYRGAIIQ VFWRLFTISS RVISFALFAS IFQLYFGIFV VVHWCAMAFW
410 420 430 440 450
IIHGGTDFCM SKWEEILFNM VVGIVYIFCW FNVKEGRTRY RMFAYYTIVL
460 470 480 490 500
TENAALTFLW YFYRDPETTD SYAVPALCCV FISFVAGIAM MLLYYGVLHP
510 520 530 540 550
TGPRAKILAS SCCAELLWGI PLPPDVEPMA PEIPGYRGTQ VTPTRAVTEQ
560 570 580 590 600
QEDLTADTCL PVFQVRPMGP PTPLGRPYLP EGPLIKIDMP RKRYPAWDAH
610 620 630 640
FVDRRLRRTI NILQYVTPTA VGIRYRDGPL LYELLQYESS L
Note: No experimental confirmation available.
Length:641
Mass (Da):71,638
Last modified:March 1, 2005 - v1
Checksum:iDEFFE0EE7CB43C79
GO
Isoform 2 (identifier: Q5GH73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):41,673
Checksum:iC19D2D71A2377610
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 279279Missing in isoform 2. 1 PublicationVSP_014663Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534244 mRNA. Translation: AAT07093.1.
BC024146 mRNA. Translation: AAH24146.1.
CCDSiCCDS5978.2. [Q5GH73-1]
RefSeqiNP_775954.2. NM_173683.3.
UniGeneiHs.657083.
Hs.665456.
Hs.666146.

Genome annotation databases

EnsembliENST00000416569; ENSP00000416707; ENSG00000171044. [Q5GH73-1]
GeneIDi286046.
KEGGihsa:286046.
UCSCiuc003wtk.3. human. [Q5GH73-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534244 mRNA. Translation: AAT07093.1.
BC024146 mRNA. Translation: AAH24146.1.
CCDSiCCDS5978.2. [Q5GH73-1]
RefSeqiNP_775954.2. NM_173683.3.
UniGeneiHs.657083.
Hs.665456.
Hs.666146.

3D structure databases

ProteinModelPortaliQ5GH73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130280. 1 interaction.
STRINGi9606.ENSP00000416707.

PTM databases

iPTMnetiQ5GH73.
PhosphoSiteiQ5GH73.

Polymorphism and mutation databases

BioMutaiXKR6.
DMDMi71153416.

Proteomic databases

PaxDbiQ5GH73.
PeptideAtlasiQ5GH73.
PRIDEiQ5GH73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000416569; ENSP00000416707; ENSG00000171044. [Q5GH73-1]
GeneIDi286046.
KEGGihsa:286046.
UCSCiuc003wtk.3. human. [Q5GH73-1]

Organism-specific databases

CTDi286046.
GeneCardsiXKR6.
HGNCiHGNC:27806. XKR6.
HPAiHPA024828.
neXtProtiNX_Q5GH73.
PharmGKBiPA134922549.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4790. Eukaryota.
ENOG410YRUD. LUCA.
GeneTreeiENSGT00530000062854.
HOGENOMiHOG000231915.
HOVERGENiHBG055841.
InParanoidiQ5GH73.
OMAiLSVWVWQ.
OrthoDBiEOG091G048S.
PhylomeDBiQ5GH73.
TreeFamiTF316454.

Miscellaneous databases

ChiTaRSiXKR6. human.
GenomeRNAii286046.
PROiQ5GH73.

Gene expression databases

BgeeiENSG00000171044.
CleanExiHS_XKR6.
ExpressionAtlasiQ5GH73. baseline and differential.
GenevisibleiQ5GH73. HS.

Family and domain databases

InterProiIPR018629. XK_fam.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXKR6_HUMAN
AccessioniPrimary (citable) accession number: Q5GH73
Secondary accession number(s): Q8TBA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.