Q5GH72 (XKR7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
XK-related protein 7

Gene names

Name:	XKR7
Synonyms:	C20orf159, XRG7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the XK family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 579	579	XK-related protein 7		PRO_0000190788
Regions
	Transmembrane	59 – 79	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	260 – 280	21	Helical; Potential
	Transmembrane	314 – 334	21	Helical; Potential
	Transmembrane	355 – 375	21	Helical; Potential
	Transmembrane	384 – 404	21	Helical; Potential
	Transmembrane	415 – 435	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5GH72 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: D8D0FF64B9EDD53D	FASTA	579	63,826
	10 20 30 40 50 60 MAAKSDGAAA SASPDPEGAA GGARGSAGGR GEAAAAAGPP GVVGAGGPGP RYELRDCCWV 70 80 90 100 110 120 LCALLVFFSD GATDLWLAAS YYLQNQHTYF SLTLLFVLLP SLVVQLLSFR WFVYDYSEPA 130 140 150 160 170 180 GSPGPAVSTK DSVAGGAAIS TKDSAGAFRT KEGSPEPGPQ PAPSSASAYR RRCCRLCIWL 190 200 210 220 230 240 LQTLVHLLQL GQVWRYLRAL YLGLQSRWRG ERLRRHFYWQ MLFESADVSM LRLLETFLRS 250 260 270 280 290 300 APQLVLQLSL LVHRGGAPDL LPALSTSASL VSLAWTLASY QKVLRDSRDD KRPLSYKGAV 310 320 330 340 350 360 AQVLWHLFSI AARGLAFALF ASVYKLYFGI FIVAHWCVMT FWVIQGETDF CMSKWEEIIY 370 380 390 400 410 420 NMVVGIIYIF CWFNVKEGRS RRRMTLYHCI VLLENAALTG FWYSSRNFST DFYSLIMVCV 430 440 450 460 470 480 VASSFALGIF FMCVYYCLLH PNGPMLGPQA PGCIFRKASE PCGPPADAIT SPPRSLPRTT 490 500 510 520 530 540 GAERDGASAG ERAGTPTPPV FQVRPGLPPT PVARTLRTEG PVIRIDLPRK KYPAWDAHFI 550 560 570 DRRLRKTILA LEYSSPATPR LQYRSVGTSQ ELLEYETTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates." Huang C.-H., Chen Y. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY534245 mRNA. Translation: AAT07094.1. AL031658 Genomic DNA. Translation: CAB88102.2.
IPI	IPI00552154.
RefSeq	NP_001011718.1. NM_001011718.1.
UniGene	Hs.666444.
3D structure databases
ProteinModelPortal	Q5GH72.
ModBase	Search...
PTM databases
PhosphoSite	Q5GH72.
Polymorphism databases
DMDM	74707816.
Proteomic databases
PRIDE	Q5GH72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000217299; ENSP00000217299; ENSG00000101321.
GeneID	343702.
KEGG	hsa:343702.
UCSC	uc002wxe.1. human.
Organism-specific databases
CTD	343702.
GeneCards	GC20P030555.
HGNC	HGNC:23062. XKR7.
HPA	HPA040854.
neXtProt	NX_Q5GH72.
PharmGKB	PA142670565.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04508.
GeneTree	ENSGT00530000062854.
HOGENOM	HBG713827.
HOVERGEN	HBG055841.
InParanoid	Q5GH72.
OMA	YCIVLLE.
OrthoDB	EOG4BCDMR.
PhylomeDB	Q5GH72.
Gene expression databases
ArrayExpress	Q5GH72.
CleanEx	HS_XKR7.
Genevestigator	Q5GH72.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR018629. Transport_prot_XK. [Graphical view]
Pfam	PF09815. XK-related. 1 hit. [Graphical view]
SMART	SM00015. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	98598.

Entry information

Entry name

XKR7_HUMAN

Accession

Primary (citable) accession number: Q5GH72
Secondary accession number(s): Q9NUG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.