Q5GH70 (XKR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
XK-related protein 9

Gene names

Name:	XKR9
Synonyms:	XRG9

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the XK family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	XK-related protein 9		PRO_0000190796
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	166 – 186	21	Helical; Potential
	Transmembrane	203 – 223	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Transmembrane	256 – 276	21	Helical; Potential
	Transmembrane	295 – 315	21	Helical; Potential
	Transmembrane	318 – 338	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5GH70 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: E6B9AF692FED626D	FASTA	373	43,406
	10 20 30 40 50 60 MKYTKQNFMM SVLGIIIYVT DLIVDIWVSV RFFHEGQYVF SALALSFMLF GTLVAQCFSY 70 80 90 100 110 120 SWFKADLKKA GQESQHCFLL LHCLQGGVFT RYWFALKRGY HAAFKYDSNT SNFVEEQIDL 130 140 150 160 170 180 HKEVIDRVTD LSMLRLFETY LEGCPQLILQ LYILLEHGQA NFSQYAAIMV SCCAISWSTV 190 200 210 220 230 240 DYQVALRKSL PDKKLLNGLC PKITYLFYKL FTLLSWMLSV VLLLFLNVKI ALFLLLFLWL 250 260 270 280 290 300 LGIIWAFKNN TQFCTCISME FLYRIVVGFI LIFTFFNIKG QNTKCPMSCY YIVRVLGTLG 310 320 330 340 350 360 ILTVFWVCPL TIFNPDYFIP ISITIVLTLL LGILFLIVYY GSFHPNRSAE TKCDEIDGKP 370 VLRECRMRYF LME

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates." Huang C.-H., Chen Y. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY534247 mRNA. Translation: AAT07096.1. BC137104 mRNA. Translation: AAI37105.1. BC137105 mRNA. Translation: AAI37106.1.
IPI	IPI00399035.
RefSeq	NP_001011720.1. NM_001011720.1.
UniGene	Hs.458938.
3D structure databases
ProteinModelPortal	Q5GH70.
ModBase	Search...
Polymorphism databases
DMDM	74707815.
Proteomic databases
PRIDE	Q5GH70.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000408926; ENSP00000386141; ENSG00000221947.
GeneID	389668.
KEGG	hsa:389668.
UCSC	uc003xyq.1. human.
Organism-specific databases
CTD	389668.
GeneCards	GC08P071581.
HGNC	HGNC:20937. XKR9.
HPA	HPA044430.
neXtProt	NX_Q5GH70.
PharmGKB	PA142670567.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19286.
GeneTree	ENSGT00530000062854.
HOGENOM	HBG715747.
HOVERGEN	HBG055839.
InParanoid	Q5GH70.
OMA	YLEGCPQ.
OrthoDB	EOG4M0F22.
Gene expression databases
Bgee	Q5GH70.
CleanEx	HS_XKR9.
Genevestigator	Q5GH70.
Family and domain databases
InterPro	IPR018629. Transport_prot_XK. [Graphical view]
Pfam	PF09815. XK-related. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	103006.

Entry information

Entry name

XKR9_HUMAN

Accession

Primary (citable) accession number: Q5GH70
Secondary accession number(s): B2RNS9, B9EH74

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.