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Protein

Membrane transport protein XK

Gene

Xk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane transport protein XK
Alternative name(s):
XK homolog
XK-related protein 1
Gene namesi
Name:Xk
Synonyms:Xkh, Xkr1, Xrg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359650. Xk.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22CytoplasmicSequence analysis
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Topological domaini24 – 3714ExtracellularSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Topological domaini59 – 6810CytoplasmicSequence analysis
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Topological domaini90 – 14051ExtracellularSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Topological domaini162 – 1709CytoplasmicSequence analysis
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Topological domaini192 – 20716ExtracellularSequence analysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence analysisAdd
BLAST
Topological domaini229 – 2346CytoplasmicSequence analysis
Transmembranei235 – 25521HelicalSequence analysisAdd
BLAST
Topological domaini256 – 27621ExtracellularSequence analysisAdd
BLAST
Transmembranei277 – 29721HelicalSequence analysisAdd
BLAST
Topological domaini298 – 31619CytoplasmicSequence analysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence analysisAdd
BLAST
Topological domaini338 – 34811ExtracellularSequence analysisAdd
BLAST
Transmembranei349 – 36921HelicalSequence analysisAdd
BLAST
Topological domaini370 – 44576CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Membrane transport protein XKPRO_0000190770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151PhosphoserineCombined sources
Disulfide bondi346 – 346Interchain (with C-53 in Kell)By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ5GH61.
PRIDEiQ5GH61.

PTM databases

iPTMnetiQ5GH61.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039017.

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE7C. Eukaryota.
ENOG410XP4P. LUCA.
HOVERGENiHBG055838.
InParanoidiQ5GH61.
KOiK19522.
PhylomeDBiQ5GH61.

Family and domain databases

InterProiIPR018629. XK_fam.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5GH61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFPASVLAS VFLFVAETMA ALYLSSTYRS AGDRMWQALT LFFSLMPCTL
60 70 80 90 100
VQLTLLFVHR DLSRDRPLVL LMHLLQLGPL YRCCEVFCIY CQSDQNEEPY
110 120 130 140 150
VSITKKRQMP KDGLSEEVEK EVGQSEGKLF THRSAFSRAS VIQAFLGSAP
160 170 180 190 200
QLTLQLYITV LEQNITTGRF IMVLSLLSIV YGALRCNILA IKIKYDEYEV
210 220 230 240 250
KVKPLAYVCI FLWRSFEIAT RVIVLVLFTS VLKIWVVVVI LVNFFSFFLY
260 270 280 290 300
PWILFWNSGS PFPENIEKAL TRVGTTIVLG FLTLLYAGIN MFCWSAVQLK
310 320 330 340 350
IDNPELISKS QNWYRLLIYY MMRFVENSVL LLLWFFFKTD IYMYVCAPLL
360 370 380 390 400
ILQLLIGYCT SILFMLVFYQ FFHPCKKLFS SSVSESFSAC LRCVCWSSAR
410 420 430 440
RKSTEPVGRI DTDLKACTDQ GAQPSTSKLT PEATEIWTAV DLCST
Length:445
Mass (Da):51,050
Last modified:March 1, 2005 - v1
Checksum:i9C8C3B499692C072
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534256 mRNA. Translation: AAT07105.1.
RefSeqiNP_001012227.1. NM_001012227.1.
UniGeneiRn.211877.

Genome annotation databases

GeneIDi497078.
KEGGirno:497078.
UCSCiRGD:1359650. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534256 mRNA. Translation: AAT07105.1.
RefSeqiNP_001012227.1. NM_001012227.1.
UniGeneiRn.211877.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039017.

PTM databases

iPTMnetiQ5GH61.

Proteomic databases

PaxDbiQ5GH61.
PRIDEiQ5GH61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi497078.
KEGGirno:497078.
UCSCiRGD:1359650. rat.

Organism-specific databases

CTDi7504.
RGDi1359650. Xk.

Phylogenomic databases

eggNOGiENOG410IE7C. Eukaryota.
ENOG410XP4P. LUCA.
HOVERGENiHBG055838.
InParanoidiQ5GH61.
KOiK19522.
PhylomeDBiQ5GH61.

Miscellaneous databases

PROiQ5GH61.

Family and domain databases

InterProiIPR018629. XK_fam.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates."
    Huang C.-H., Chen Y.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 410-415, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiXK_RAT
AccessioniPrimary (citable) accession number: Q5GH61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2005
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.