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Protein

Membrane transport protein XK

Gene

Xk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane transport protein XK
Alternative name(s):
XK homolog
XK-related protein 1
Gene namesi
Name:Xk
Synonyms:Xkh, Xkr1, Xrg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359650. Xk.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2CytoplasmicSequence analysis2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 37ExtracellularSequence analysisAdd BLAST14
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 68CytoplasmicSequence analysis10
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 140ExtracellularSequence analysisAdd BLAST51
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 170CytoplasmicSequence analysis9
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 207ExtracellularSequence analysisAdd BLAST16
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 234CytoplasmicSequence analysis6
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 276ExtracellularSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 316CytoplasmicSequence analysisAdd BLAST19
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 348ExtracellularSequence analysisAdd BLAST11
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370 – 445CytoplasmicSequence analysisAdd BLAST76

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001907701 – 445Membrane transport protein XKAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphoserineCombined sources1
Disulfide bondi346Interchain (with C-53 in Kell)By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ5GH61.
PRIDEiQ5GH61.

PTM databases

iPTMnetiQ5GH61.
PhosphoSitePlusiQ5GH61.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039017.

Structurei

3D structure databases

ProteinModelPortaliQ5GH61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE7C. Eukaryota.
ENOG410XP4P. LUCA.
HOVERGENiHBG055838.
InParanoidiQ5GH61.
KOiK19522.
PhylomeDBiQ5GH61.

Family and domain databases

InterProiIPR018629. XK_rel.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5GH61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFPASVLAS VFLFVAETMA ALYLSSTYRS AGDRMWQALT LFFSLMPCTL
60 70 80 90 100
VQLTLLFVHR DLSRDRPLVL LMHLLQLGPL YRCCEVFCIY CQSDQNEEPY
110 120 130 140 150
VSITKKRQMP KDGLSEEVEK EVGQSEGKLF THRSAFSRAS VIQAFLGSAP
160 170 180 190 200
QLTLQLYITV LEQNITTGRF IMVLSLLSIV YGALRCNILA IKIKYDEYEV
210 220 230 240 250
KVKPLAYVCI FLWRSFEIAT RVIVLVLFTS VLKIWVVVVI LVNFFSFFLY
260 270 280 290 300
PWILFWNSGS PFPENIEKAL TRVGTTIVLG FLTLLYAGIN MFCWSAVQLK
310 320 330 340 350
IDNPELISKS QNWYRLLIYY MMRFVENSVL LLLWFFFKTD IYMYVCAPLL
360 370 380 390 400
ILQLLIGYCT SILFMLVFYQ FFHPCKKLFS SSVSESFSAC LRCVCWSSAR
410 420 430 440
RKSTEPVGRI DTDLKACTDQ GAQPSTSKLT PEATEIWTAV DLCST
Length:445
Mass (Da):51,050
Last modified:March 1, 2005 - v1
Checksum:i9C8C3B499692C072
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534256 mRNA. Translation: AAT07105.1.
RefSeqiNP_001012227.1. NM_001012227.1.
UniGeneiRn.211877.

Genome annotation databases

GeneIDi497078.
KEGGirno:497078.
UCSCiRGD:1359650. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534256 mRNA. Translation: AAT07105.1.
RefSeqiNP_001012227.1. NM_001012227.1.
UniGeneiRn.211877.

3D structure databases

ProteinModelPortaliQ5GH61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039017.

PTM databases

iPTMnetiQ5GH61.
PhosphoSitePlusiQ5GH61.

Proteomic databases

PaxDbiQ5GH61.
PRIDEiQ5GH61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi497078.
KEGGirno:497078.
UCSCiRGD:1359650. rat.

Organism-specific databases

CTDi7504.
RGDi1359650. Xk.

Phylogenomic databases

eggNOGiENOG410IE7C. Eukaryota.
ENOG410XP4P. LUCA.
HOVERGENiHBG055838.
InParanoidiQ5GH61.
KOiK19522.
PhylomeDBiQ5GH61.

Miscellaneous databases

PROiQ5GH61.

Family and domain databases

InterProiIPR018629. XK_rel.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXK_RAT
AccessioniPrimary (citable) accession number: Q5GH61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.