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Protein

Inactive ribonuclease-like protein 10

Gene

RNASE10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Fertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive ribonuclease-like protein 10
Gene namesi
Name:RNASE10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000182545.6.
HGNCiHGNC:19275. RNASE10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182545.
PharmGKBiPA134878150.

Polymorphism and mutation databases

BioMutaiRNASE10.
DMDMi74741482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000004596327 – 216Inactive ribonuclease-like protein 10Add BLAST190

Post-translational modificationi

The N-terminus is blocked. Glycosylated (By similarity).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5GAN6.
PeptideAtlasiQ5GAN6.
PRIDEiQ5GAN6.

Expressioni

Gene expression databases

BgeeiENSG00000182545.
CleanExiHS_RNASE10.
ExpressionAtlasiQ5GAN6. baseline and differential.

Organism-specific databases

HPAiHPA052593.

Interactioni

Protein-protein interaction databases

BioGridi130810. 1 interactor.
IntActiQ5GAN6. 4 interactors.
STRINGi9606.ENSP00000333358.

Structurei

3D structure databases

ProteinModelPortaliQ5GAN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWKC. Eukaryota.
ENOG41118N9. LUCA.
GeneTreeiENSGT00730000111443.
HOGENOMiHOG000236357.
HOVERGENiHBG080734.
InParanoidiQ5GAN6.
OMAiKCHKSSR.
OrthoDBiEOG091G15X3.
PhylomeDBiQ5GAN6.
TreeFamiTF337410.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiView protein in InterPro
IPR029742. RNASE10.
IPR001427. RNaseA.
IPR036816. RNaseA-like_dom_sf.
IPR023412. RNaseA_domain.
PANTHERiPTHR11437. PTHR11437. 1 hit.
PTHR11437:SF2. PTHR11437:SF2. 1 hit.
PfamiView protein in Pfam
PF00074. RnaseA. 1 hit.
PRINTSiPR00794. RIBONUCLEASE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000535. RNaseA. 1 hit.
SMARTiView protein in SMART
SM00092. RNAse_Pc. 1 hit.
SUPFAMiSSF54076. SSF54076. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5GAN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLNLVQIFF MLLMLLLGLG MGLGLGLHMA TAVLEESDQP LNEFWSSDSQ
60 70 80 90 100
DKAEATEEGD GTQTTETLVL SNKEVVQPGW PEDPILGEDE VGGNKMLRAS
110 120 130 140 150
ALFQSNKDYL RLDQTDRECN DMMAHKMKEP SQSCIAQYAF IHEDLNTVKA
160 170 180 190 200
VCNSPVIACE LKGGKCHKSS RPFDLTLCEL SQPDQVTPNC NYLTSVIKKH
210
IIITCNDMKR QLPTGQ
Length:216
Mass (Da):24,008
Last modified:March 1, 2005 - v1
Checksum:i0A6438BFDCA73271
GO
Isoform 2 (identifier: Q5GAN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWGAPLPRRPVWDVRSASAGPQPCLGGKM

Show »
Length:244
Mass (Da):26,981
Checksum:i61184B87E3C9EE50
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052198131S → N. Corresponds to variant dbSNP:rs2067648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0535791M → MWGAPLPRRPVWDVRSASAG PQPCLGGKM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665805 mRNA. Translation: AAV87183.1.
AK296766 mRNA. Translation: BAG59346.1.
AL355075 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66457.1.
BC133002 mRNA. Translation: AAI33003.1.
BC133028 mRNA. Translation: AAI33029.1.
CCDSiCCDS32035.1. [Q5GAN6-1]
RefSeqiNP_001012993.1. NM_001012975.1. [Q5GAN6-1]
UniGeneiHs.451057.

Genome annotation databases

EnsembliENST00000328444; ENSP00000333358; ENSG00000182545. [Q5GAN6-1]
ENST00000430083; ENSP00000392996; ENSG00000182545. [Q5GAN6-2]
GeneIDi338879.
KEGGihsa:338879.
UCSCiuc001vxp.2. human. [Q5GAN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRNS10_HUMAN
AccessioniPrimary (citable) accession number: Q5GAN6
Secondary accession number(s): A2RUQ3, B4DKY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: March 1, 2005
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families