ID   RNS12_MOUSE             Reviewed;         145 AA.
AC   Q5GAM8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   24-JAN-2024, entry version 107.
DE   RecName: Full=Probable inactive ribonuclease-like protein 12;
DE   Flags: Precursor;
GN   Name=Rnase12;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=15676279; DOI=10.1016/j.ygeno.2004.10.008;
RA   Cho S., Beintema J.J., Zhang J.;
RT   "The ribonuclease A superfamily of mammals and birds: identifying new
RT   members and tracing evolutionary histories.";
RL   Genomics 85:208-220(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Does not exhibit any ribonuclease activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; AY665824; AAV87191.1; -; Genomic_DNA.
DR   EMBL; BC146014; AAI46015.1; -; mRNA.
DR   EMBL; BC146016; AAI46017.1; -; mRNA.
DR   CCDS; CCDS27032.1; -.
DR   RefSeq; NP_001011875.1; NM_001011875.2.
DR   AlphaFoldDB; Q5GAM8; -.
DR   SMR; Q5GAM8; -.
DR   STRING; 10090.ENSMUSP00000154201; -.
DR   PaxDb; 10090-ENSMUSP00000087231; -.
DR   ProteomicsDB; 260825; -.
DR   Antibodypedia; 57709; 99 antibodies from 17 providers.
DR   DNASU; 497106; -.
DR   Ensembl; ENSMUST00000089798.3; ENSMUSP00000087231.3; ENSMUSG00000068407.4.
DR   Ensembl; ENSMUST00000227764.2; ENSMUSP00000154201.2; ENSMUSG00000068407.4.
DR   GeneID; 497106; -.
DR   KEGG; mmu:497106; -.
DR   UCSC; uc007tmj.2; mouse.
DR   AGR; MGI:3528588; -.
DR   CTD; 493901; -.
DR   MGI; MGI:3528588; Rnase12.
DR   VEuPathDB; HostDB:ENSMUSG00000068407; -.
DR   eggNOG; ENOG502T3VJ; Eukaryota.
DR   GeneTree; ENSGT00730000111478; -.
DR   HOGENOM; CLU_117006_1_0_1; -.
DR   InParanoid; Q5GAM8; -.
DR   OMA; KHVFIHE; -.
DR   OrthoDB; 5249162at2759; -.
DR   PhylomeDB; Q5GAM8; -.
DR   TreeFam; TF333393; -.
DR   BioGRID-ORCS; 497106; 1 hit in 78 CRISPR screens.
DR   PRO; PR:Q5GAM8; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q5GAM8; Protein.
DR   Bgee; ENSMUSG00000068407; Expressed in blastoderm cell in morula and 29 other cell types or tissues.
DR   ExpressionAtlas; Q5GAM8; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004540; F:RNA nuclease activity; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   Gene3D; 3.10.130.10; Ribonuclease A-like domain; 1.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR11437:SF20; INACTIVE RIBONUCLEASE-LIKE PROTEIN 12-RELATED; 1.
DR   PANTHER; PTHR11437; RIBONUCLEASE; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   PRINTS; PR00794; RIBONUCLEASE.
DR   SMART; SM00092; RNAse_Pc; 1.
DR   SUPFAM; SSF54076; RNase A-like; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..145
FT                   /note="Probable inactive ribonuclease-like protein 12"
FT                   /id="PRO_0000308703"
SQ   SEQUENCE   145 AA;  16936 MW;  723032269725AD05 CRC64;
     MVLMVVVFLL LLFWENELTE DVVLTSIEQL HVDYPQNAVP LRYCNYMILQ RVIREPDHRC
     RKVHVFIHER PQKINRVCTS SKKMSCPNDS DLFCFQSETK FRMTVCQLID GTTYPACRYQ
     ISPIKGFVLV TCDDLGPVDL QGYVE
//